Please Wait

Applying Filters...

Technical details about Halobetasol Propionate, learn more about the structure, uses, toxicity, action, side effects and more

Halobetasol Propionate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

20 Suppliers, 9 USDMF, 2 EU WC, 6 NDC API, 17 Listed Suppliers

DEVELOPMENTS

5 Drug(s) in Development

5 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports

DOSSIERs // Finished Dosage Forms

26 Dossiers, 20 FDA Orange Book, 4 Canada, 2 Listed Dossiers

DRUG PRODUCT COMPOSITION

CREAM;TOPICAL - 0.05% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, OINTMENT;TOPICAL - 0.05% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, AEROSOL, FOAM;TOPICAL - 0.05%

RELATED EXCIPIENT COMPANIES

Suppliers, 6 BASF, 2 Nanjing Well Pharmaceutical, 2 Actylis, 2 Corel Pharma Chem, 2 Lubrizol Life Science Health, 1 Nanjing Bold Chemical, 1 Kerry, 1 Gangwal Chemicals, 1 Microlex e.U, 1 Finar

EXCIPIENTS BY APPLICATIONS

10 Topical, 5 Thickeners and Stabilizers, 4 Solubilizers, 4 Parenteral, 2 Lubricants & Glidants, 2 Direct Compression, 2 Film Formers & Plasticizers, 2 Granulation, 1 Surfactant & Foaming Agents, 1 Fillers, Diluents & Binders, 1 Chewable & Orodispersible Aids, 1 Emulsifying Agents, 1 Coating Systems & Additives, 1 Controlled & Modified Release

GLOBAL SALES INFORMATION

27 US Medicaid Prescriptions, 6 Finished Drug Prices

MARKET PLACE

7 APIs

7 APIs

PATENTS

14 US Patents, 2 US Exclusivities

REF. STANDARDS & IMPURITIES

1 USP, 1 Others

DIGITAL CONTENT

27 News

27 News

1. Also known as: Ulobetasol propionate, 66852-54-8, Ultravate, Miracorten, Halobetasol (propionate), Bmy-30056

Molecular Formula

C₂₅H₃₁ClF₂O₅

Molecular Weight

485.0 g/mol

InChI Key

BDSYKGHYMJNPAB-LICBFIPMSA-N

FDA UNII

91A0K1TY3Z

Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

2.1.2 InChI

InChI=1S/C25H31ClF2O5/c1-5-21(32)33-25(20(31)12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15-,16-,18-,19-,22-,23-,24-,25-/m0/s1

2.1.3 InChI Key

BDSYKGHYMJNPAB-LICBFIPMSA-N

2.1.4 Canonical SMILES

CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)CCl

2.1.5 Isomeric SMILES

CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)CCl

2.2 Other Identifiers

2.2.1 UNII

91A0K1TY3Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 6 Alpha-fluoroclobetasol 17-propionate

2. 6-fluoroclobetasol 17-propionate

3. Cgp 14 458

4. Cgp 14458

5. Cgp-14458

6. Halobetasol

7. Ulobetasol

8. Ultravate

2.3.2 Depositor-Supplied Synonyms

1. Ulobetasol Propionate

2. 66852-54-8

3. Ultravate

4. Miracorten

5. Halobetasol (propionate)

6. Bmy-30056

7. Jemdel

8. Cgp-14458

9. Cgp-14,458

10. 91a0k1ty3z

11. Unii-91a0k1ty3z

12. Halobetasol Propionate [usan]

13. Ultravate (tn)

14. Ncgc00167451-01

15. Halobetasol Propionate [usan:usp]

16. [(6s,8s,9r,10s,11s,13s,14s,16s,17r)-17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Propanoate

17. Bmy 30056

18. Bryhali

19. Halobetasol-propionate

20. Bmy-30056;cgp-14458;ulobetasol Propionate

21. Dsstox_cid_26636

22. Dsstox_rid_81782

23. Dsstox_gsid_46636

24. Schembl33858

25. Halobetasol Propionate (usp)

26. Chembl1200908

27. Dtxsid6046636

28. Chebi:135782

29. Halobetasol Propionate [mi]

30. (6s,8s,9r,10s,11s,13s,14s,16s,17r)-17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl Propionate

31. Hy-b0878

32. Zinc3920028

33. Tox21_112455

34. Mfcd00866013

35. S4089

36. Halobetasol Propionate [vandf]

37. Ulobetasol Propionate [mart.]

38. Akos025310143

39. Ulobetasol Propionate [who-dd]

40. Ccg-269585

41. Cs-4305

42. Halobetasol Propionate [usp-rs]

43. Ncgc00373230-02

44. 21-chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate

45. Cas-66852-54-8

46. Halobetasol Propionate [orange Book]

47. Halobetasol Propionate [usp Monograph]

48. D04409

49. Duobrii Component Halobetasol Propionate

50. Ab01566925_01

51. Idp-118 Component Halobetasol Propionate

52. 852h548

53. Halobetasol Propionate Component Of Duobrii

54. Sr-01000942239

55. Sr-01000942239-1

56. (6alpha,11beta,16beta)-21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione

57. 21-chloro-6.alpha.,9-difluoro-11.beta.,17-dihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17-propionate

58. Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6.alpha.,11.beta.,16.beta.)-

59. Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6alpha,11beta,16beta)-

2.4 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₃₁ClF₂O₅
Molecular Weight	485.0 g/mol
XLogP3	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	484.1828081 g/mol
Monoisotopic Mass	484.1828081 g/mol
Topological Polar Surface Area	80.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	964
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Halobetasol propionate
Drug Label	Halonate Halobetasol Propionate Ointment, 0.05% contains halobetasol propionate, a synthetic corticosteroid for topical dermatological use. The corticosteroids constitute a class of primarily synthetic steroids used topically as an anti-inflammatory...
Active Ingredient	Halobetasol propionate
Dosage Form	Ointment; Cream
Route	Topical
Strength	0.05%
Market Status	Prescription
Company	Taro; Fougera Pharms; Perrigo; G And W Labs; Perrigo Israel

2 of 2
Drug Name	Halobetasol propionate
Drug Label	Halonate Halobetasol Propionate Ointment, 0.05% contains halobetasol propionate, a synthetic corticosteroid for topical dermatological use. The corticosteroids constitute a class of primarily synthetic steroids used topically as an anti-inflammatory...
Active Ingredient	Halobetasol propionate
Dosage Form	Ointment; Cream
Route	Topical
Strength	0.05%
Market Status	Prescription
Company	Taro; Fougera Pharms; Perrigo; G And W Labs; Perrigo Israel

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

POST ENQUIRY