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    Technical details about Garenoxacin, learn more about the structure, uses, toxicity, action, side effects and more

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    Garenoxacin

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    INTERMEDIATES

    DIGITAL CONTENT

    PharmaCompass

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    2D Structure
    1. Also known as: 194804-75-6, Ganefloxacin, T-3811, T 3811, Bms284756, (r)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
    Molecular Formula
    C23H20F2N2O4
    Molecular Weight
    426.4  g/mol
    InChI Key
    NJDRXTDGYFKORP-LLVKDONJSA-N
    FDA UNII
    V72H9867WB
    Garenoxacin, a quinolone antibiotic, is being investigated for the treatment of gram-positive and gram-negative bacterial infections.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid
    2.1.2 InChI
    InChI=1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m1/s1
    2.1.3 InChI Key
    NJDRXTDGYFKORP-LLVKDONJSA-N
    2.1.4 Canonical SMILES
    CC1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
    2.1.5 Isomeric SMILES
    C[C@@H]1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    V72H9867WB
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bms 284756

    2. Bms-284756

    3. Bms284756

    2.3.2 Depositor-Supplied Synonyms

    1. 194804-75-6

    2. Ganefloxacin

    3. T-3811

    4. T 3811

    5. Bms284756

    6. (r)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

    7. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-1-methyl-2,3-dihydro-1h-isoindol-5-yl]-4-oxoquinoline-3-carboxylic Acid

    8. V72h9867wb

    9. Bms-284756

    10. Garenfloxacin

    11. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-1-methyl-2,3-dihydro-1h-isoindol-5-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

    12. 194804-75-6 Pound Not223652-90-2

    13. Ncgc00181770-01

    14. Garenoxacin [inn:ban]

    15. Bms 284756 (*mesylate Salt*)

    16. Garenoxacine

    17. Garenoxacino

    18. Garenoxacinum

    19. Unii-v72h9867wb

    20. T-3811mea

    21. Bms-284756 (*mesylate Salt*)

    22. Garenoxacin [mi]

    23. Garenoxacin [inn]

    24. Garenoxacin [mart.]

    25. Garenoxacin [who-dd]

    26. Chembl215303

    27. Schembl2103727

    28. Amy8881

    29. Dtxsid30173135

    30. Chebi:131716

    31. Bcpp000224

    32. Bcp01415

    33. Ex-a3040

    34. Zinc3585048

    35. Bdbm50481219

    36. S5908

    37. Akos015920281

    38. Bcp9000709

    39. Cs-4989

    40. Db06160

    41. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-(1-methyl-2,3-dihydro-1h-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid

    42. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-1-methylisoindolin-5-yl]-4-oxo-quinoline-3-carboxylic Acid

    43. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-2,3-dihydro-1-methyl-1h-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

    44. Hy-17460

    45. A16856

    46. 804g756

    47. J-012614

    48. J-521409

    49. Q3758306

    50. (r)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2, 3-dihydro-1h-5-isoindolyl)-4-oxo-1, 4-dihydro-3-quinolinecarboxylic Acid

    51. (r)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1h-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinoline-carboxylic Acid

    52. (r)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1h-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid

    2.4 Create Date
    2005-08-01
    3 Chemical and Physical Properties
    Molecular Weight 426.4 g/mol
    Molecular Formula C23H20F2N2O4
    XLogP32.1
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass426.13911345 g/mol
    Monoisotopic Mass426.13911345 g/mol
    Topological Polar Surface Area78.9 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity771
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in bacterial infection.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Topoisomerase II Inhibitors

    Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    5.2 ATC Code

    J - Antiinfectives for systemic use

    J01 - Antibacterials for systemic use

    J01M - Quinolone antibacterials

    J01MA - Fluoroquinolones

    J01MA19 - Garenoxacin

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