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    Technical details about Floctafenine, learn more about the structure, uses, toxicity, action, side effects and more

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    Floctafenine

    PRICE INFORMATION

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    Phyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

    Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

    2D Structure
    1. Also known as: 23779-99-9, Novodolan, Idarac, Diralgan, Idalon, 2,3-dihydroxypropyl 2-((8-(trifluoromethyl)quinolin-4-yl)amino)benzoate
    Molecular Formula
    C20H17F3N2O4
    Molecular Weight
    406.4  g/mol
    InChI Key
    APQPGQGAWABJLN-UHFFFAOYSA-N
    FDA UNII
    O04HVX6A9Q
    Floctafenine is an anti-inflammatory analgesic similar in action to aspirin. Floctafenine inhibits prostaglandin synthesis.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2,3-dihydroxypropyl 2-[[8-(trifluoromethyl)quinolin-4-yl]amino]benzoate
    2.1.2 InChI
    InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)
    2.1.3 InChI Key
    APQPGQGAWABJLN-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC=C(C3=NC=C2)C(F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    O04HVX6A9Q
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Duralgin

    2. Floctafenin

    3. Idalon

    4. Idarac

    5. Novodolan

    6. R 4318

    7. Ru 15750

    2.3.2 Depositor-Supplied Synonyms

    1. 23779-99-9

    2. Novodolan

    3. Idarac

    4. Diralgan

    5. Idalon

    6. 2,3-dihydroxypropyl 2-((8-(trifluoromethyl)quinolin-4-yl)amino)benzoate

    7. Floctafenin

    8. Ru 15750

    9. R 4318

    10. 2,3-dihydroxypropyl 2-[[8-(trifluoromethyl)quinolin-4-yl]amino]benzoate

    11. 8-trifluoromethyl-7-deschloroglafenine

    12. 2,3-dihydroxypropyl 2-((8-(trifluoromethyl)-quinolin-4-yl)amino)benzoate

    13. Ru-15750

    14. 2,3-dihydroxypropyl N-(8-(trifluoromethyl)-4-quinolyl)anthranilate

    15. O04hvx6a9q

    16. Benzoic Acid, 2-((8-(trifluoromethyl)-4-quinolinyl)amino)-, 2,3-dihydroxypropyl Ester

    17. R-4138

    18. R-4318

    19. 2-(8'-trifluoromethyl-4'-quinolylamino)benzoic Acid 2,3-dihydroxy Propyl Ester

    20. 4-(o-(2',3'-dihydroxypropyloxycarbonyl)phenyl)-amino-8-trifluoromethylquinoline

    21. Benzoic Acid, 2-(8'-trifluoromethyl-4'-quinolylamino)-, 2,3-dihydroxypropyl Ester

    22. Benzoic Acid, 2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-, 2,3-dihydroxypropyl Ester

    23. Floctafenina

    24. Floctafeninum

    25. Duralgin

    26. Floctafeninum [inn-latin]

    27. Floctafenina [inn-spanish]

    28. Einecs 245-881-4

    29. Unii-o04hvx6a9q

    30. Brn 0457808

    31. Floctafenine [usan:inn:ban:jan]

    32. Idarac (tn)

    33. Floctafenine [mi]

    34. Floctafenine [inn]

    35. Floctafenine [jan]

    36. Floctafenine [usan]

    37. Dsstox_cid_31484

    38. Dsstox_rid_97369

    39. Dsstox_gsid_57695

    40. Schembl26841

    41. Floctafenine [mart.]

    42. Floctafenine [who-dd]

    43. Floctafenine (jan/usan/inn)

    44. Chembl2105075

    45. Dtxsid8057695

    46. Chebi:31612

    47. Hy-a0259

    48. Tox21_113688

    49. Akos015998661

    50. Db08976

    51. Sb73211

    52. Ncgc00249912-01

    53. Cas-23779-99-9

    54. Cs-0017604

    55. Ft-0668555

    56. D01267

    57. A878143

    58. Q5459971

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 406.4 g/mol
    Molecular Formula C20H17F3N2O4
    XLogP33.7
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count7
    Exact Mass406.11404151 g/mol
    Monoisotopic Mass406.11404151 g/mol
    Topological Polar Surface Area91.7 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity548
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    4.2 ATC Code

    N - Nervous system

    N02 - Analgesics

    N02B - Other analgesics and antipyretics

    N02BG - Other analgesics and antipyretics

    N02BG04 - Floctafenine

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