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    Dovramilast

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    2D Structure
    Also known as: 340019-69-4, Cc-11050, 1z08g7438a, Cc11050, Cyclopropanecarboxamide, n-(2-((1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-3-oxo-1h-isoindol-4-yl)-, Cyclopropanecarboxamide, n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-3-oxo-1h-isoindol-4-yl]-
    Molecular Formula
    C24H28N2O6S
    Molecular Weight
    472.6  g/mol
    InChI Key
    QDZOBXFRIVOQBR-LJQANCHMSA-N
    FDA UNII
    1Z08G7438A
    DOVRAMILAST is a small molecule drug with a maximum clinical trial phase of II (across all indications) and has 2 investigational indications.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-3-oxo-1H-isoindol-4-yl]cyclopropanecarboxamide
    2.1.2 InChI
    InChI=1S/C24H28N2O6S/c1-4-32-21-12-16(10-11-20(21)31-2)19(14-33(3,29)30)26-13-17-6-5-7-18(22(17)24(26)28)25-23(27)15-8-9-15/h5-7,10-12,15,19H,4,8-9,13-14H2,1-3H3,(H,25,27)/t19-/m1/s1
    2.1.3 InChI Key
    QDZOBXFRIVOQBR-LJQANCHMSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    1Z08G7438A
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cc-11050

    2.3.2 Depositor-Supplied Synonyms

    1. 340019-69-4

    2. Cc-11050

    3. 1z08g7438a

    4. Cc11050

    5. Cyclopropanecarboxamide, N-(2-((1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-3-oxo-1h-isoindol-4-yl)-

    6. Cyclopropanecarboxamide, N-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-3-oxo-1h-isoindol-4-yl]-

    7. Refchem:124078

    8. Unii-1z08g7438a

    9. N-(2-((1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-3-oxo-2,3-dihydro-1h-isoindol-4-yl)cyclopropanecarboxamide

    10. N-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-3-oxo-1h-isoindol-4-yl]cyclopropanecarboxamide

    11. (s)-n-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-3-oxoisoindolin-4-yl)cyclopropanecarboxamide

    12. Dovramilast [inn]

    13. Schembl673303

    14. Orb1686985

    15. Chembl4297460

    16. Schembl29366888

    17. Schembl30701938

    18. Gtpl13581

    19. Amg-634

    20. Qdzobxfrivoqbr-ljqanchmsa-n

    21. Ex-a12042

    22. Da-72891

    23. Ms-28749

    24. Hy-147263

    25. Cs-0542404

    26. H42759

    27. Cyclopropyl-n-{2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindolin-4-yl}carboxamide

    28. N-{2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2- (methanesulfonyl)ethyl]-3-oxo-2,3-dihydro-1h-isoindol- 4-yl}cyclopropanecarboxamide

    29. N-{2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-3-oxo-2,3-dihydro-1h-isoindol-4-yl}cyclopropanecarboxamide

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 472.6 g/mol
    Molecular Formula C24H28N2O6S
    XLogP32.4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count9
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area110
    Heavy Atom Count33
    Formal Charge0
    Complexity823
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Phosphodiesterase 4 Inhibitors

    Compounds that specifically inhibit PHOSPHODIESTERASE 4.