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Technical details about Diclofenac Hydroxyethylpyrrolidine, learn more about the structure, uses, toxicity, action, side effects and more

Diclofenac Hydroxyethylpyrrolidine

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

8 Suppliers, 7 USDMF, 2 KDMF, 4 NDC API, 3 Listed Suppliers

DEVELOPMENTS

8 Drug(s) in Development

8 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports

DOSSIERs // Finished Dosage Forms

5 Dossiers, 2 FDA Orange Book, 1 Europe, 2 South Africa

RELATED EXCIPIENT COMPANIES

Suppliers, 11 BASF, 11 Roquette, 6 Seppic, 5 Nanjing Well Pharmaceutical, 5 Gangwal Chemicals, 4 Microlex e.U, 4 ACG Worldwide, 3 Boai NKY Pharmaceuticals Ltd, 3 Lonza Capsugel, 3 SPI Pharma, 2 Ulanqab Kema New Material, 2 Actylis, 2 Rochem International Inc, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Sigachi Industries, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Gangwal Healthcare, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Finar, 1 Nanjing Bold Chemical, 1 Pharmatrans-Sanaq, 1 Jai Radhe Sales, 1 Zhejiang Huakang Pharmaceutical, 1 DKSH, 1 Qualicaps, 1 Kima Chemical, 1 The Dow Chemical Company, 1 Aeon Procare

EXCIPIENTS BY APPLICATIONS

24 Solubilizers, 17 Fillers, Diluents & Binders, 14 Film Formers & Plasticizers, 12 Parenteral, 8 Thickeners and Stabilizers, 8 Coating Systems & Additives, 8 Empty Capsules, 7 Topical, 6 Direct Compression, 5 Granulation, 5 Taste Masking, 4 Controlled & Modified Release, 4 Rheology Modifiers, 3 Emulsifying Agents, 3 Co-Processed Excipients, 3 Disintegrants & Superdisintegrants, 2 Chewable & Orodispersible Aids, 2 API Stability Enhancers, 2 Surfactant & Foaming Agents, 1 Lubricants & Glidants, 1 Soft Gelatin

GLOBAL SALES INFORMATION

16 US Medicaid Prescriptions, 1 Finished Drug Prices

MARKET PLACE

2 APIs

2 APIs

PATENTS

2 US Patents

2 US Patents

ANALYTICAL SOLUTION(s)

1 BioAnalytical Methods

1 BioAnalytical Methods

DIGITAL CONTENT

3 News

3 News

Also known as: Flector, Diclofenac hydroxyethylpyrrolidine, Diep, Dhep, Diclofenac epolaminum, Diclofenac-epolamine

Molecular Formula

C₂₀H₂₄Cl₂N₂O₃

Molecular Weight

411.3 g/mol

InChI Key

DCERVXIINVUMKU-UHFFFAOYSA-N

FDA UNII

X5F8EKL9ZG

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[2-(2,6-dichloroanilino)phenyl]acetic acid;2-pyrrolidin-1-ylethanol

2.1.2 InChI

InChI=1S/C14H11Cl2NO2.C6H13NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;8-6-5-7-3-1-2-4-7/h1-7,17H,8H2,(H,18,19);8H,1-6H2

2.1.3 InChI Key

DCERVXIINVUMKU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CCN(C1)CCO.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

2.2 Other Identifiers

2.2.1 UNII

X5F8EKL9ZG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dhep

2. Diclofenac 1-(2-hydroxyethyl)pyrrolidinium Salt

3. Diclofenac Hydroxyethylpyrrolidine

4. Diclofenac-epolamine

5. Diclofenac-n-(2-hydroxyethyl) Pyrrolidine

6. Diep

7. Flector

8. N-(2-hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate

2.3.2 Depositor-Supplied Synonyms

1. Flector

2. Diclofenac Hydroxyethylpyrrolidine

3. Diep

4. Dhep

5. Diclofenac Epolaminum

6. Diclofenac-epolamine

7. X5f8ekl9zg

8. 2-[2-(2,6-dichloroanilino)phenyl]acetic Acid;2-pyrrolidin-1-ylethanol

9. N-(2-hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate

10. 2-((2,6-dichlorophenyl)amino)benzeneacetic Acid, Compd. With 1-pyrrolidineethanol (1:1)

11. Diclofenac 1-(2-hydroxyethyl)pyrrolidinium Salt

12. Dhep Plaster

13. Benzeneacetic Acid, 2-((2,6-dichlorophenyl)amino)-, Compd. With 1-pyrrolidineethanol (1:1)

14. Chebi:48296

15. Unii-x5f8ekl9zg

16. Flector (tn)

17. Licart

18. Diclofenac-n-(2-hydroxyethyl) Pyrrolidine

19. Schembl1006944

20. Chembl1201180

21. Dtxsid80152531

22. Diclofenac Epolamine [vandf]

23. Diclofenac Epolamine [mart.]

24. S5737

25. Diclofenac Epolamine [who-dd]

26. Diclofenac Hydroxyethylpirrolidine

27. Diclofenac Epolamine [orange Book]

28. D07818

29. 528d502

30. Diclofenac Acid N-(2-hydroxyetheyl) Pyrrolidine Salt

31. Q27121125

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₄Cl₂N₂O₃
Molecular Weight	411.3 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	410.1163980 g/mol
Monoisotopic Mass	410.1163980 g/mol
Topological Polar Surface Area	72.8 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	363
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Flector
PubMed Health	Diclofenac
Drug Classes	Analgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug Label	Flector Patch (10 cm x 14 cm) is comprised of an adhesive material containing 1.3% diclofenac epolamine which is applied to a non-woven polyester felt backing and coveredwith a polypropylene film release liner. The release liner is emoved prior to...
Active Ingredient	Diclofenac epolamine
Dosage Form	Patch
Route	Topical
Strength	1.3%
Market Status	Prescription
Company	Inst Biochem

2 of 2
Drug Name	Flector
PubMed Health	Diclofenac
Drug Classes	Analgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug Label	Flector Patch (10 cm x 14 cm) is comprised of an adhesive material containing 1.3% diclofenac epolamine which is applied to a non-woven polyester felt backing and coveredwith a polypropylene film release liner. The release liner is emoved prior to...
Active Ingredient	Diclofenac epolamine
Dosage Form	Patch
Route	Topical
Strength	1.3%
Market Status	Prescription
Company	Inst Biochem

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cyclooxygenase Inhibitors [MoA]; Decreased Prostaglandin Production [PE]; Nonsteroidal Anti-inflammatory Drug [EPC]; Anti-Inflammatory Agents, Non-Steroidal [CS]

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