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    Corticorelin

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    2D Structure
    Also known as: Corticorelin [inn], 305oe8862y, Corticorelin (human) (jan), Corticotropin-releasing factor, Acth-releasing factor, Corticorelin (human) [jan]
    Molecular Formula
    C208H344N60O63S2
    Molecular Weight
    4757  g/mol
    InChI Key
    GBONBLHJMVUBSJ-FAUHKOHMSA-N
    A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-oxopentanoic acid
    2.1.2 InChI
    InChI=1S/C208H344N60O63S2/c1-30-106(20)161(165(215)291)263-202(328)163(108(22)32-3)264-184(310)129(58-67-157(285)286)243-182(308)131(70-78-333-29)246-187(313)134(80-99(6)7)250-176(302)118(45-36-37-71-209)237-174(300)120(47-39-73-225-207(218)219)239-194(320)143(89-152(214)276)256-197(323)145(94-270)260-193(319)141(87-115-91-222-96-227-115)248-169(295)112(26)230-172(298)122(51-60-149(211)273)240-177(303)123(52-61-150(212)274)234-168(294)111(25)232-185(311)133(79-98(4)5)249-181(307)124(53-62-151(213)275)241-178(304)125(54-63-153(277)278)235-167(293)110(24)229-171(297)119(46-38-72-224-206(216)217)233-166(292)109(23)231-173(299)130(69-77-332-28)245-179(305)127(56-65-155(281)282)244-188(314)138(84-103(14)15)258-200(326)160(105(18)19)262-183(309)128(57-66-156(283)284)242-175(301)121(48-40-74-226-208(220)221)238-186(312)135(81-100(8)9)251-189(315)136(82-101(10)11)252-192(318)142(88-116-92-223-97-228-116)255-191(317)140(86-114-43-34-33-35-44-114)259-203(329)164(113(27)272)266-196(322)139(85-104(16)17)253-195(321)144(90-159(289)290)257-190(316)137(83-102(12)13)254-198(324)146(95-271)261-201(327)162(107(21)31-2)265-199(325)147-49-41-75-267(147)205(331)148-50-42-76-268(148)204(330)132(59-68-158(287)288)247-180(306)126(55-64-154(279)280)236-170(296)117(210)93-269/h33-35,43-44,91-92,96-113,117-148,160-164,269-272H,30-32,36-42,45-90,93-95,209-210H2,1-29H3,(H2,211,273)(H2,212,274)(H2,213,275)(H2,214,276)(H2,215,291)(H,222,227)(H,223,228)(H,229,297)(H,230,298)(H,231,299)(H,232,311)(H,233,292)(H,234,294)(H,235,293)(H,236,296)(H,237,300)(H,238,312)(H,239,320)(H,240,303)(H,241,304)(H,242,301)(H,243,308)(H,244,314)(H,245,305)(H,246,313)(H,247,306)(H,248,295)(H,249,307)(H,250,302)(H,251,315)(H,252,318)(H,253,321)(H,254,324)(H,255,317)(H,256,323)(H,257,316)(H,258,326)(H,259,329)(H,260,319)(H,261,327)(H,262,309)(H,263,328)(H,264,310)(H,265,325)(H,266,322)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H4,216,217,224)(H4,218,219,225)(H4,220,221,226)/t106-,107-,108-,109-,110-,111-,112-,113+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,160-,161-,162-,163-,164-/m0/s1
    2.1.3 InChI Key
    GBONBLHJMVUBSJ-FAUHKOHMSA-N
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Corticotropin-releasing Hormone

    2. Acth-releasing Factor

    3. Corticoliberin

    4. Corticotropin-releasing Factor

    5. Corticotropin-releasing Factor-41

    6. Corticotropin-releasing Hormone-41

    7. Crf-41

    8. Acth-releasing Hormone

    9. Crf (acth)

    2.2.2 Depositor-Supplied Synonyms

    1. Corticorelin [inn]

    2. 305oe8862y

    3. Corticorelin (human) (jan)

    4. Corticotropin-releasing Factor

    5. Acth-releasing Factor

    6. Corticorelin (human) [jan]

    7. Corticorelin (human) (mart.)

    8. Corticorelin (human) [mart.]

    9. Corticorelin (human)

    10. Acth Releasing Factor

    11. Crf-41

    12. Crf (acth)

    13. Corticorelinum

    14. Endorpholiberin

    15. Corticorelina

    16. Corticoreline

    17. Corticotropin Releasing Factor

    18. Corticorelin Human

    19. Corticotropin Releasing Factor 41

    20. Corticotropin-releasing Factor-41

    21. Dtxsid301033334

    22. Corticoliberin Human

    23. Human Corticoliberin

    24. Neu-3002

    25. Refchem:579252

    26. Chebi:65311

    27. V04cd04

    28. Corticotropin Releasing Hormone Human

    29. Corticorelin (human) [who-dd]

    30. Therapeutic Corticotropin-releasing Factor

    31. Corticotropin-releasing Factor, Human

    32. Recombinant Human Corticotropin Releasing Factor

    33. 9015-71-8

    34. Corticoliberin

    35. Neu 3002

    36. Corticotropin-releasing Factor (human)

    37. Xerecept

    38. Crf (human, Rat) Acetate

    39. Corticobiss

    40. Human Corticorelin

    41. Human Crf

    42. Rat Crf

    43. Rat Hypothalamic Crf

    44. Corticorelin Acetate Human

    45. Human Crf (1-41)

    46. Neu-3002 Acetate

    47. Rat Crf(1-41)

    48. Ccris 5322

    49. Crf 41

    50. Chembl2107324

    51. Schembl29357284

    52. Unii-305oe8862y

    53. Mci 028

    54. Chebi:136037

    55. Rat Corticotropin-releasing Factor

    56. Pcr-4136-v

    57. Human Corticotropin-releasing Factor

    58. Corticotropin-releasing Factor (rat)

    59. Rat Corticotropin-releasing Factor-41

    60. Akos024456419

    61. Corticotropin-releasing Factor (horse)

    62. Fc108671

    63. G91173

    64. Corticotropin-releasing Factor, Human, Rat

    65. Corticoliberin, Corticorelin, Crf-41, Crh, Corticotropin Releasing Factor, Human, Rat

    66. Corticotropin-releasing Factor (sheep), 2-l-glutamic Acid-22-l-alanine-23-l-arginine-25-l-glutamic Acid-38-l-methionine-39-l-glutamic Acid-41-l-isoleucinamide-

    67. H-ser-glu-glu-pro-pro-ile-ser-leu-asp-leu-thr- Phe-his-leu-leu-arg-glu-val-leu-glu-met-ala-arg-ala-glu-gln-leu-ala-gln-gln-ala-his-ser-asn-arg-lys-leu-met-glu-ile-il

    68. Ser-glu-glu-pro-pro-ile-ser-leu-asp-leu-thr-phe-his-leu-leu-arg-glu-val-leu-glu-met-ala-arg-ala-glu-gln-leu-ala-gln-gln-ala-his-ser- Asn- Arg-lys-leu-met-glu-ile-ile-nh2 Corticotropin-releasing Factor (human, Rat)

    2.3 Create Date
    2007-07-04
    3 Chemical and Physical Properties
    Molecular Weight 4757 g/mol
    Molecular Formula C208H344N60O63S2
    XLogP3-14.3
    Hydrogen Bond Donor Count67
    Hydrogen Bond Acceptor Count72
    Rotatable Bond Count166
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area2050
    Heavy Atom Count333
    Formal Charge0
    Complexity11700
    Isotope Atom Count0
    Defined Atom Stereocenter Count45
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in brain cancer and neurologic disorders.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Hormones

    Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.

    5.2 ATC Code

    V - Various

    V04 - Diagnostic agents

    V04C - Other diagnostic agents

    V04CD - Tests for pituitary function

    V04CD04 - Corticorelin

    ATCvet Code

    QV - Various

    QV04 - Diagnostic agents

    QV04C - Other diagnostic agents

    QV04CD - Tests for pituitary function

    QV04CD04 - Corticorelin

    5.3 Mechanism of Action

    Corticotropin-releasing factor is produced by neuroendocrine cells in the paraventricular nucleus of the hypothalamus and is released from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system. The portal system carries the Corticotropin-releasing hormone(CRH) to the anterior lobe of the pituitary where it stimulates the secretion of corticotropin (ACTH) and other biologically active substances.

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