Find Corticorelin manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

0

USDMF

0

CEP/COS

0

JDMF

0

EU WC

0

KDMF

0

NDC API

0

VMF

0

Listed Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

0

FDA Orange Book

0

Europe

0

Canada

0

Australia

0

South Africa

0

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Corticorelin [inn], 305oe8862y, Corticorelin (human) (jan), Corticotropin-releasing factor, Acth-releasing factor, Corticorelin (human) [jan]
Molecular Formula
C208H344N60O63S2
Molecular Weight
4757  g/mol
InChI Key
GBONBLHJMVUBSJ-FAUHKOHMSA-N

Corticorelin
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
1 2D Structure

Corticorelin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C208H344N60O63S2/c1-30-106(20)161(165(215)291)263-202(328)163(108(22)32-3)264-184(310)129(58-67-157(285)286)243-182(308)131(70-78-333-29)246-187(313)134(80-99(6)7)250-176(302)118(45-36-37-71-209)237-174(300)120(47-39-73-225-207(218)219)239-194(320)143(89-152(214)276)256-197(323)145(94-270)260-193(319)141(87-115-91-222-96-227-115)248-169(295)112(26)230-172(298)122(51-60-149(211)273)240-177(303)123(52-61-150(212)274)234-168(294)111(25)232-185(311)133(79-98(4)5)249-181(307)124(53-62-151(213)275)241-178(304)125(54-63-153(277)278)235-167(293)110(24)229-171(297)119(46-38-72-224-206(216)217)233-166(292)109(23)231-173(299)130(69-77-332-28)245-179(305)127(56-65-155(281)282)244-188(314)138(84-103(14)15)258-200(326)160(105(18)19)262-183(309)128(57-66-156(283)284)242-175(301)121(48-40-74-226-208(220)221)238-186(312)135(81-100(8)9)251-189(315)136(82-101(10)11)252-192(318)142(88-116-92-223-97-228-116)255-191(317)140(86-114-43-34-33-35-44-114)259-203(329)164(113(27)272)266-196(322)139(85-104(16)17)253-195(321)144(90-159(289)290)257-190(316)137(83-102(12)13)254-198(324)146(95-271)261-201(327)162(107(21)31-2)265-199(325)147-49-41-75-267(147)205(331)148-50-42-76-268(148)204(330)132(59-68-158(287)288)247-180(306)126(55-64-154(279)280)236-170(296)117(210)93-269/h33-35,43-44,91-92,96-113,117-148,160-164,269-272H,30-32,36-42,45-90,93-95,209-210H2,1-29H3,(H2,211,273)(H2,212,274)(H2,213,275)(H2,214,276)(H2,215,291)(H,222,227)(H,223,228)(H,229,297)(H,230,298)(H,231,299)(H,232,311)(H,233,292)(H,234,294)(H,235,293)(H,236,296)(H,237,300)(H,238,312)(H,239,320)(H,240,303)(H,241,304)(H,242,301)(H,243,308)(H,244,314)(H,245,305)(H,246,313)(H,247,306)(H,248,295)(H,249,307)(H,250,302)(H,251,315)(H,252,318)(H,253,321)(H,254,324)(H,255,317)(H,256,323)(H,257,316)(H,258,326)(H,259,329)(H,260,319)(H,261,327)(H,262,309)(H,263,328)(H,264,310)(H,265,325)(H,266,322)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H4,216,217,224)(H4,218,219,225)(H4,220,221,226)/t106-,107-,108-,109-,110-,111-,112-,113+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,160-,161-,162-,163-,164-/m0/s1
2.1.3 InChI Key
GBONBLHJMVUBSJ-FAUHKOHMSA-N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Corticotropin-releasing Hormone

2. Acth-releasing Factor

3. Corticoliberin

4. Corticotropin-releasing Factor

5. Corticotropin-releasing Factor-41

6. Corticotropin-releasing Hormone-41

7. Crf-41

8. Acth-releasing Hormone

9. Crf (acth)

2.2.2 Depositor-Supplied Synonyms

1. Corticorelin [inn]

2. 305oe8862y

3. Corticorelin (human) (jan)

4. Corticotropin-releasing Factor

5. Acth-releasing Factor

6. Corticorelin (human) [jan]

7. Corticorelin (human) (mart.)

8. Corticorelin (human) [mart.]

9. Corticorelin (human)

10. Acth Releasing Factor

11. Crf-41

12. Crf (acth)

13. Corticorelinum

14. Endorpholiberin

15. Corticorelina

16. Corticoreline

17. Corticotropin Releasing Factor

18. Corticorelin Human

19. Corticotropin Releasing Factor 41

20. Corticotropin-releasing Factor-41

21. Dtxsid301033334

22. Corticoliberin Human

23. Human Corticoliberin

24. Neu-3002

25. Refchem:579252

26. Chebi:65311

27. V04cd04

28. Corticotropin Releasing Hormone Human

29. Corticorelin (human) [who-dd]

30. Therapeutic Corticotropin-releasing Factor

31. Corticotropin-releasing Factor, Human

32. Recombinant Human Corticotropin Releasing Factor

33. 9015-71-8

34. Corticoliberin

35. Neu 3002

36. Corticotropin-releasing Factor (human)

37. Xerecept

38. Crf (human, Rat) Acetate

39. Corticobiss

40. Human Corticorelin

41. Human Crf

42. Rat Crf

43. Rat Hypothalamic Crf

44. Corticorelin Acetate Human

45. Human Crf (1-41)

46. Neu-3002 Acetate

47. Rat Crf(1-41)

48. Ccris 5322

49. Crf 41

50. Chembl2107324

51. Schembl29357284

52. Unii-305oe8862y

53. Mci 028

54. Chebi:136037

55. Rat Corticotropin-releasing Factor

56. Pcr-4136-v

57. Human Corticotropin-releasing Factor

58. Corticotropin-releasing Factor (rat)

59. Rat Corticotropin-releasing Factor-41

60. Akos024456419

61. Corticotropin-releasing Factor (horse)

62. Fc108671

63. G91173

64. Corticotropin-releasing Factor, Human, Rat

65. Corticoliberin, Corticorelin, Crf-41, Crh, Corticotropin Releasing Factor, Human, Rat

66. Corticotropin-releasing Factor (sheep), 2-l-glutamic Acid-22-l-alanine-23-l-arginine-25-l-glutamic Acid-38-l-methionine-39-l-glutamic Acid-41-l-isoleucinamide-

67. H-ser-glu-glu-pro-pro-ile-ser-leu-asp-leu-thr- Phe-his-leu-leu-arg-glu-val-leu-glu-met-ala-arg-ala-glu-gln-leu-ala-gln-gln-ala-his-ser-asn-arg-lys-leu-met-glu-ile-il

68. Ser-glu-glu-pro-pro-ile-ser-leu-asp-leu-thr-phe-his-leu-leu-arg-glu-val-leu-glu-met-ala-arg-ala-glu-gln-leu-ala-gln-gln-ala-his-ser- Asn- Arg-lys-leu-met-glu-ile-ile-nh2 Corticotropin-releasing Factor (human, Rat)

2.3 Create Date
2007-07-04
3 Chemical and Physical Properties
Molecular Weight 4757 g/mol
Molecular Formula C208H344N60O63S2
XLogP3-14.3
Hydrogen Bond Donor Count67
Hydrogen Bond Acceptor Count72
Rotatable Bond Count166
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area2050
Heavy Atom Count333
Formal Charge0
Complexity11700
Isotope Atom Count0
Defined Atom Stereocenter Count45
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in brain cancer and neurologic disorders.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Hormones

Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.


5.2 ATC Code

V - Various

V04 - Diagnostic agents

V04C - Other diagnostic agents

V04CD - Tests for pituitary function

V04CD04 - Corticorelin


ATCvet Code

QV - Various

QV04 - Diagnostic agents

QV04C - Other diagnostic agents

QV04CD - Tests for pituitary function

QV04CD04 - Corticorelin


5.3 Mechanism of Action

Corticotropin-releasing factor is produced by neuroendocrine cells in the paraventricular nucleus of the hypothalamus and is released from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system. The portal system carries the Corticotropin-releasing hormone(CRH) to the anterior lobe of the pituitary where it stimulates the secretion of corticotropin (ACTH) and other biologically active substances.


ABOUT THIS PAGE

Looking for 86784-80-7 / Corticorelin API manufacturers, exporters & distributors?

Corticorelin manufacturers, exporters & distributors 1

67

PharmaCompass offers a list of Corticorelin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Corticorelin manufacturer or Corticorelin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Corticorelin manufacturer or Corticorelin supplier.

API | Excipient name

Corticorelin

Synonyms

Corticorelin [inn], 305oe8862y, Corticorelin (human) (jan), Corticotropin-releasing factor, Acth-releasing factor, Corticorelin (human) [jan]

Cas Number

86784-80-7

About Corticorelin

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

Corticorelin Manufacturers

A Corticorelin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Corticorelin, including repackagers and relabelers. The FDA regulates Corticorelin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Corticorelin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Corticorelin Suppliers

A Corticorelin supplier is an individual or a company that provides Corticorelin active pharmaceutical ingredient (API) or Corticorelin finished formulations upon request. The Corticorelin suppliers may include Corticorelin API manufacturers, exporters, distributors and traders.

Corticorelin GMP

Corticorelin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Corticorelin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Corticorelin GMP manufacturer or Corticorelin GMP API supplier for your needs.

Corticorelin CoA

A Corticorelin CoA (Certificate of Analysis) is a formal document that attests to Corticorelin's compliance with Corticorelin specifications and serves as a tool for batch-level quality control.

Corticorelin CoA mostly includes findings from lab analyses of a specific batch. For each Corticorelin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Corticorelin may be tested according to a variety of international standards, such as European Pharmacopoeia (Corticorelin EP), Corticorelin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Corticorelin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty