Find Zilebesiran manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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KDMF

KDMF

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NDC API

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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PATENTS & EXCLUSIVITIES

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Chemistry

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Also known as: Dj674lg53m, Zilebesiran 3'-adenosine modification sodium, L96 (n-acetylgalactosamine (galnac) containing) 3'-adenosine modification sodium
Molecular Formula
C89H152N16NaO36P
Molecular Weight
2076.2  g/mol
InChI Key
FUHMXNACFUZXIQ-ZHSRMXMESA-M
FDA UNII
DJ674LG53M

Zilebesiran
1 2D Structure

Zilebesiran

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;[(2S,4R)-1-[12-[[1-[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]-3-[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-methyloxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]propan-2-yl]amino]-12-oxododecanoyl]-4-hydroxypyrrolidin-2-yl]methyl [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-yl] phosphate
2.1.2 InChI
InChI=1S/C89H153N16O36P.Na/c1-54-75(121)78(124)71(100-55(2)109)86(137-54)133-37-17-14-23-63(113)91-31-20-34-94-66(116)28-40-130-49-89(50-131-41-29-67(117)95-35-21-32-92-64(114)24-15-18-38-134-87-72(101-56(3)110)79(125)76(122)60(45-106)139-87,51-132-42-30-68(118)96-36-22-33-93-65(115)25-16-19-39-135-88-73(102-57(4)111)80(126)77(123)61(46-107)140-88)103-69(119)26-12-10-8-6-7-9-11-13-27-70(120)104-44-59(112)43-58(104)48-136-142(127,128)141-81-62(47-108)138-85(82(81)129-5)105-53-99-74-83(90)97-52-98-84(74)105;/h52-54,58-62,71-73,75-82,85-88,106-108,112,121-126H,6-51H2,1-5H3,(H,91,113)(H,92,114)(H,93,115)(H,94,116)(H,95,117)(H,96,118)(H,100,109)(H,101,110)(H,102,111)(H,103,119)(H,127,128)(H2,90,97,98);/q;+1/p-1/t54-,58+,59-,60-,61-,62-,71-,72-,73-,75+,76+,77+,78-,79-,80-,81-,82-,85-,86-,87-,88-;/m1./s1
2.1.3 InChI Key
FUHMXNACFUZXIQ-ZHSRMXMESA-M
2.1.4 Canonical SMILES
CC1C(C(C(C(O1)OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCOC2C(C(C(C(O2)CO)O)O)NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCOC3C(C(C(C(O3)CO)O)O)NC(=O)C)NC(=O)CCCCCCCCCCC(=O)N4CC(CC4COP(=O)([O-])OC5C(OC(C5OC)N6C=NC7=C(N=CN=C76)N)CO)O)NC(=O)C)O)O.[Na+]
2.1.5 Isomeric SMILES
C[C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(=O)C)NC(=O)CCCCCCCCCCC(=O)N4C[C@@H](C[C@H]4COP(=O)([O-])O[C@@H]5[C@H](O[C@H]([C@@H]5OC)N6C=NC7=C(N=CN=C76)N)CO)O)NC(=O)C)O)O.[Na+]
2.2 Other Identifiers
2.2.1 UNII
DJ674LG53M
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Dj674lg53m

2. Zilebesiran 3'-adenosine Modification Sodium

3. L96 (n-acetylgalactosamine (galnac) Containing) 3'-adenosine Modification Sodium

2.4 Create Date
2021-05-16
3 Chemical and Physical Properties
Molecular Weight 2076.2 g/mol
Molecular Formula C89H152N16NaO36P
Hydrogen Bond Donor Count21
Hydrogen Bond Acceptor Count40
Rotatable Bond Count70
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area743
Heavy Atom Count143
Formal Charge0
Complexity3730
Isotope Atom Count0
Defined Atom Stereocenter Count21
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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Looking for / Zilebesiran API manufacturers, exporters & distributors?

Zilebesiran manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Zilebesiran API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Zilebesiran manufacturer or Zilebesiran supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Zilebesiran manufacturer or Zilebesiran supplier.

PharmaCompass also assists you with knowing the Zilebesiran API Price utilized in the formulation of products. Zilebesiran API Price is not always fixed or binding as the Zilebesiran Price is obtained through a variety of data sources. The Zilebesiran Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Zilebesiran

Synonyms

Dj674lg53m, Zilebesiran 3'-adenosine modification sodium, L96 (n-acetylgalactosamine (galnac) containing) 3'-adenosine modification sodium

Unique Ingredient Identifier (UNII)

DJ674LG53M

Zilebesiran Manufacturers

A Zilebesiran manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zilebesiran, including repackagers and relabelers. The FDA regulates Zilebesiran manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zilebesiran API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Zilebesiran Suppliers

A Zilebesiran supplier is an individual or a company that provides Zilebesiran active pharmaceutical ingredient (API) or Zilebesiran finished formulations upon request. The Zilebesiran suppliers may include Zilebesiran API manufacturers, exporters, distributors and traders.

Zilebesiran GMP

Zilebesiran Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Zilebesiran GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zilebesiran GMP manufacturer or Zilebesiran GMP API supplier for your needs.

Zilebesiran CoA

A Zilebesiran CoA (Certificate of Analysis) is a formal document that attests to Zilebesiran's compliance with Zilebesiran specifications and serves as a tool for batch-level quality control.

Zilebesiran CoA mostly includes findings from lab analyses of a specific batch. For each Zilebesiran CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Zilebesiran may be tested according to a variety of international standards, such as European Pharmacopoeia (Zilebesiran EP), Zilebesiran JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zilebesiran USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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