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Chemistry

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Also known as: Tng-462, 2760483-96-1, Tng462, A1bv0, N-(6-amino-5-ethylpyridin-3-yl)-2-[(2r,5s)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide, N-(6-amino-5-ethylpyridin-3-yl)-2-{(2r,5s)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl}-2-oxoacetamide
Molecular Formula
C28H36N6O2S
Molecular Weight
520.7  g/mol
InChI Key
DHAGMIPSRSPWSH-GAJHUEQPSA-N
FDA UNII
54P82QYL4L

Vopimetostat
Vopimetostat is an orally bioavailable small molecule inhibitor of protein arginine methyltransferase 5 (PRMT5), with potential antiproliferative and antineoplastic activities. Upon oral administration, vopimetostat selectively targets, binds to, and inhibits the activity of PRMT5. By inhibiting its methyltransferase activity, levels of both monomethylated and dimethylated arginine residues in histones H2A, H3 and H4 are decreased. This modulates the expression of genes involved in several cellular processes, including cellular proliferation. This may increase the expression of antiproliferative genes and/or decrease the expression of genes that promote cell proliferation, which may lead to decreased growth of rapidly proliferating cells, including cancer cells. PRMT5, a type II methyltransferase that catalyzes the formation of both omega-N monomethylarginine (MMA) and symmetric dimethylarginine (sDMA) on histones and a variety of other protein substrates involved in signal transduction and cellular transcription, is overexpressed in several neoplasms and is essential for the viability of cancer and normal cells. Elevated levels are associated with decreased patient survival. Methylthioadenosine phosphorylase (MTAP) is deleted in certain cancer cells leading to an accumulation of methylthioadenosine (MTA). As MTA binds to and partially inhibits PRMT5, MTAP-null cancer cells are specifically sensitive to PRMT5 inhibitors. This may spare normal, healthy cells that are without MTAP-deletions and lower systemic toxicity.
1 2D Structure

Vopimetostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-(6-amino-5-ethyl-3-pyridinyl)-2-[(2R,5S)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide
2.1.2 InChI
InChI=1S/C28H36N6O2S/c1-4-18-13-21(15-30-25(18)29)31-26(35)28(36)34-16-17(2)5-7-23(34)20-6-8-24-22(14-20)32-27(37-24)19-9-11-33(3)12-10-19/h6,8,13-15,17,19,23H,4-5,7,9-12,16H2,1-3H3,(H2,29,30)(H,31,35)/t17-,23+/m0/s1
2.1.3 InChI Key
DHAGMIPSRSPWSH-GAJHUEQPSA-N
2.2 Other Identifiers
2.2.1 UNII
54P82QYL4L
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Tng-462

2. 2760483-96-1

3. Tng462

4. A1bv0

5. N-(6-amino-5-ethylpyridin-3-yl)-2-[(2r,5s)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide

6. N-(6-amino-5-ethylpyridin-3-yl)-2-{(2r,5s)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl}-2-oxoacetamide

7. Vopimetostat [inn]

8. 54p82qyl4l

9. Orb2277604

10. Schembl24364686

11. Schembl31057907

12. Gtpl12902

13. Glxc-27708

14. Ex-a7971

15. Nsc856534

16. At42401

17. Nsc-856534

18. Da-68242

19. Sy370249

20. Hy-156680

21. Cs-0889154

22. (2r,5s)-n-(6-amino-5-ethyl-3-pyridinyl)-5-methyl-2-[2-(1-methyl-4-piperidinyl)- 5-benzothiazolyl]-+/--oxo-1-piperidineacetamide

23. (2r,5s)-n-(6-amino-5-ethyl-3-pyridinyl)-5-methyl-2-[2-(1-methyl-4-piperidinyl)-5-benzothiazolyl]-alpha-oxo-1-piperidineacetamide

24. 1-piperidineacetamide, N-(6-amino-5-ethyl-3-pyridinyl)-5-methyl-2-[2-(1-methyl-4-piperidinyl)-5-benzothiazolyl]-alpha-oxo-, (2r,5s)-

25. N-(6-amino-5-ethyl-3-pyridyl)-2-[(2r,5s)-5-methyl-2-[2-(1-methyl-4-piperidyl)benzo[d]thiazol-5-yl]-1-piperidyl]-2-oxoacetamide

2.4 Create Date
2022-08-27
3 Chemical and Physical Properties
Molecular Weight 520.7 g/mol
Molecular Formula C28H36N6O2S
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area133
Heavy Atom Count37
Formal Charge0
Complexity808
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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Looking for 2760483-96-1 / Vopimetostat API manufacturers, exporters & distributors?

Vopimetostat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Vopimetostat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Vopimetostat manufacturer or Vopimetostat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vopimetostat manufacturer or Vopimetostat supplier.

API | Excipient name

Vopimetostat

Synonyms

Tng-462, 2760483-96-1, Tng462, A1bv0, N-(6-amino-5-ethylpyridin-3-yl)-2-[(2r,5s)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide, N-(6-amino-5-ethylpyridin-3-yl)-2-{(2r,5s)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl}-2-oxoacetamide

Cas Number

2760483-96-1

Unique Ingredient Identifier (UNII)

54P82QYL4L

About Vopimetostat

Vopimetostat is an orally bioavailable small molecule inhibitor of protein arginine methyltransferase 5 (PRMT5), with potential antiproliferative and antineoplastic activities. Upon oral administration, vopimetostat selectively targets, binds to, and inhibits the activity of PRMT5. By inhibiting its methyltransferase activity, levels of both monomethylated and dimethylated arginine residues in histones H2A, H3 and H4 are decreased. This modulates the expression of genes involved in several cellular processes, including cellular proliferation. This may increase the expression of antiproliferative genes and/or decrease the expression of genes that promote cell proliferation, which may lead to decreased growth of rapidly proliferating cells, including cancer cells. PRMT5, a type II methyltransferase that catalyzes the formation of both omega-N monomethylarginine (MMA) and symmetric dimethylarginine (sDMA) on histones and a variety of other protein substrates involved in signal transduction and cellular transcription, is overexpressed in several neoplasms and is essential for the viability of cancer and normal cells. Elevated levels are associated with decreased patient survival. Methylthioadenosine phosphorylase (MTAP) is deleted in certain cancer cells leading to an accumulation of methylthioadenosine (MTA). As MTA binds to and partially inhibits PRMT5, MTAP-null cancer cells are specifically sensitive to PRMT5 inhibitors. This may spare normal, healthy cells that are without MTAP-deletions and lower systemic toxicity.

Vopimetostat Manufacturers

A Vopimetostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vopimetostat, including repackagers and relabelers. The FDA regulates Vopimetostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vopimetostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vopimetostat Suppliers

A Vopimetostat supplier is an individual or a company that provides Vopimetostat active pharmaceutical ingredient (API) or Vopimetostat finished formulations upon request. The Vopimetostat suppliers may include Vopimetostat API manufacturers, exporters, distributors and traders.

Vopimetostat GMP

Vopimetostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vopimetostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Vopimetostat GMP manufacturer or Vopimetostat GMP API supplier for your needs.

Vopimetostat CoA

A Vopimetostat CoA (Certificate of Analysis) is a formal document that attests to Vopimetostat's compliance with Vopimetostat specifications and serves as a tool for batch-level quality control.

Vopimetostat CoA mostly includes findings from lab analyses of a specific batch. For each Vopimetostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vopimetostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Vopimetostat EP), Vopimetostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vopimetostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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