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    Chemistry

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    Also known as: Sodium 2-propylpentanoate, 1069-66-5, Valproate sodium, Valproic acid sodium salt, Valproic acid sodium, Depacon
    Molecular Formula
    C8H15NaO2
    Molecular Weight
    166.19  g/mol
    InChI Key
    AEQFSUDEHCCHBT-UHFFFAOYSA-M
    FDA UNII
    5VOM6GYJ0D
    Sodium Valproate
    A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
    1 2D Structure

    Sodium Valproate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;2-propylpentanoate
    2.1.2 InChI
    InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
    2.1.3 InChI Key
    AEQFSUDEHCCHBT-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CCCC(CCC)C(=O)[O-].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    5VOM6GYJ0D
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2 Propylpentanoic Acid

    2. 2-propylpentanoic Acid

    3. Calcium Valproate

    4. Convulsofin

    5. Depakene

    6. Depakine

    7. Depakote

    8. Dipropyl Acetate

    9. Divalproex

    10. Divalproex Sodium

    11. Ergenyl

    12. Magnesium Valproate

    13. Propylisopropylacetic Acid

    14. Semisodium Valproate

    15. Valproate

    16. Valproate Calcium

    17. Valproate Sodium

    18. Valproic Acid

    19. Valproic Acid, Sodium Salt (2:1)

    20. Vupral

    2.3.2 Depositor-Supplied Synonyms

    1. Sodium 2-propylpentanoate

    2. 1069-66-5

    3. Valproate Sodium

    4. Valproic Acid Sodium Salt

    5. Valproic Acid Sodium

    6. Depacon

    7. Sodium 2-propylvalerate

    8. Epilim

    9. Valproic Acid, Sodium Salt

    10. Pentanoic Acid, 2-propyl-, Sodium Salt

    11. 2-propylvaleric Acid Sodium Salt

    12. Valerin

    13. 2-propylpentanoic Acid Sodium Salt

    14. Valproic Acid Sodium Salt (1:1)

    15. Valproic Acid (sodium Salt)

    16. Selenica

    17. Abbott 44090

    18. Valproate Sodium [usan]

    19. Valproate

    20. Valproic Acid, Sodium

    21. Valproic Acid Sodium Salt (sodium Valproate)

    22. Sodium;2-propylpentanoate

    23. Mfcd00078604

    24. 5vom6gyj0d

    25. Abbott-44090

    26. Chebi:9925

    27. Eurekene

    28. Labazene

    29. Orfiril

    30. Kw-6066n

    31. Nsc-732626

    32. Nsc-757376

    33. Depakene (tn)

    34. Natrium Valproat

    35. Valproate Sodium (usan)

    36. A-44090

    37. Dipropylacetate Sodium

    38. Sodium Dipropylacetate

    39. Sodium Bispropylacetate

    40. Chembl433

    41. Valproinsaeure, Natrium

    42. Sodium N-dipropylacetate

    43. 2-propylpentanoic Acid Sodium

    44. Smr000875243

    45. Sodium 2-n-propyl-pentanoate

    46. Kw 6066n

    47. Einecs 213-961-8

    48. Unii-5vom6gyj0d

    49. Valeric Acid, 2-propyl-, Sodium Salt

    50. Natrii Valproas

    51. Valproate Sodium [usan:usp]

    52. Valproicacidsodium

    53. Selenica (tn)

    54. Valproic Acid (sodium)

    55. Lopac-p-4543

    56. Sodium Valproate (jp17)

    57. Dsstox_cid_17072

    58. Dsstox_rid_79301

    59. Dsstox_gsid_37072

    60. Schembl35027

    61. Mls001332431

    62. Mls001332432

    63. Mls002153189

    64. Spectrum1500606

    65. Sodium Valproate [jan]

    66. Dtxsid5037072

    67. Valproate Sodium [vandf]

    68. Hms500n15

    69. Valproic Acid Sodium Salt, 98%

    70. Sodium Valproate [mart.]

    71. Sodium Valproate [who-ip]

    72. Valproate Sodium [who-dd]

    73. Hms1921i21

    74. Hms2092c12

    75. Hms2230e16

    76. Hms3262b20

    77. Hms3369l11

    78. Hms3648a12

    79. Hms3654i14

    80. Hms3872g13

    81. Hms3884e05

    82. Bcp02888

    83. Tox21_302623

    84. Tox21_500889

    85. Ccg-40071

    86. Hy-10585a

    87. S1168

    88. 2-propyl-pentanoic Acid, Sodium Salt

    89. Akos005066057

    90. Valproate Sodium [orange Book]

    91. Ac-8391

    92. Ccg-208088

    93. Ccg-266330

    94. Cs-1764

    95. Lp00889

    96. Natrii Valproas [who-ip Latin]

    97. Nsc 732626

    98. Nsc 757376

    99. Sodium Valproate [ep Monograph]

    100. Valproate Sodium [usp Impurity]

    101. Ncgc00016192-01

    102. Ncgc00016192-02

    103. Ncgc00016192-03

    104. Ncgc00016192-04

    105. Ncgc00094208-01

    106. Ncgc00094208-02

    107. Ncgc00094208-03

    108. Ncgc00167849-01

    109. Ncgc00256651-01

    110. Ncgc00261574-01

    111. As-13150

    112. Sy058189

    113. 2-propylpentanoic Acid Sodium Salt (1:1)

    114. Bcp0726000316

    115. Cas-1069-66-5

    116. Db-059527

    117. Sodium 2-propylpentanoate [who-ip]

    118. Eu-0100889

    119. Ft-0633278

    120. S0894

    121. Sw219169-2

    122. D00710

    123. H11308

    124. P 4543

    125. Valproic Acid Sodium Salt (1:1) [mi]

    126. Pentanoic Acid, 2-propyl-, Sodium Salt (1:1)

    127. Valproic Acid, Sodium Salt - Cas 1069-66-5

    128. Q-201918

    129. Q4347890

    130. Sodium Valproate, British Pharmacopoeia (bp) Reference Standard

    131. Sodium Valproate, European Pharmacopoeia (ep) Reference Standard

    132. Sodium Valproate, 2-propylpentanoic Acid . Na, Sodium 2-propylpentanoate

    2.4 Create Date
    2007-11-13
    3 Chemical and Physical Properties
    Molecular Weight 166.19 g/mol
    Molecular Formula C8H15NaO2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass166.09697400 g/mol
    Monoisotopic Mass166.09697400 g/mol
    Topological Polar Surface Area40.1 Ų
    Heavy Atom Count11
    Formal Charge0
    Complexity98.3
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameDepacon
    PubMed HealthValproate Sodium (Injection)
    Drug ClassesAnticonvulsant
    Drug LabelDepacon (valproate sodium) is the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, cry...
    Active IngredientValproate sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 100mg base/ml
    Market StatusPrescription
    CompanyAbbvie

    2 of 4  
    Drug NameValproate sodium
    PubMed HealthValproate Sodium (Injection)
    Drug ClassesAnticonvulsant
    Drug LabelValproate sodium injection, USPis the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorles...
    Active IngredientValproate sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 100mg base/ml
    Market StatusPrescription
    CompanyBedford; Hikma Farmaceutica; Fresenius Kabi Usa

    3 of 4  
    Drug NameDepacon
    PubMed HealthValproate Sodium (Injection)
    Drug ClassesAnticonvulsant
    Drug LabelDepacon (valproate sodium) is the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, cry...
    Active IngredientValproate sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 100mg base/ml
    Market StatusPrescription
    CompanyAbbvie

    4 of 4  
    Drug NameValproate sodium
    PubMed HealthValproate Sodium (Injection)
    Drug ClassesAnticonvulsant
    Drug LabelValproate sodium injection, USPis the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorles...
    Active IngredientValproate sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 100mg base/ml
    Market StatusPrescription
    CompanyBedford; Hikma Farmaceutica; Fresenius Kabi Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anticonvulsants

    Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

    Antimanic Agents

    Agents that are used to treat bipolar disorders or mania associated with other affective disorders. (See all compounds classified as Antimanic Agents.)

    Enzyme Inhibitors

    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

    GABA Agents

    Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as GABA Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Decreased Central Nervous System Disorganized Electrical Activity [PE]; Mood Stabilizer [EPC]; Anti-epileptic Agent [EPC]

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    06-Jan-2022
    27-May-2025
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    ABOUT THIS PAGE

    Looking for 1069-66-5 / Sodium Valproate API manufacturers, exporters & distributors?

    Sodium Valproate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Sodium Valproate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Valproate manufacturer or Sodium Valproate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium Valproate manufacturer or Sodium Valproate supplier.

    PharmaCompass also assists you with knowing the Sodium Valproate API Price utilized in the formulation of products. Sodium Valproate API Price is not always fixed or binding as the Sodium Valproate Price is obtained through a variety of data sources. The Sodium Valproate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Sodium Valproate

    Synonyms

    Sodium 2-propylpentanoate, 1069-66-5, Valproate sodium, Valproic acid sodium salt, Valproic acid sodium, Depacon

    Cas Number

    1069-66-5

    Unique Ingredient Identifier (UNII)

    5VOM6GYJ0D

    About Sodium Valproate

    A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.

    Valproic acid sodium salt (Sodium valproate) Manufacturers

    A Valproic acid sodium salt (Sodium valproate) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Valproic acid sodium salt (Sodium valproate), including repackagers and relabelers. The FDA regulates Valproic acid sodium salt (Sodium valproate) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Valproic acid sodium salt (Sodium valproate) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Valproic acid sodium salt (Sodium valproate) manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Valproic acid sodium salt (Sodium valproate) Suppliers

    A Valproic acid sodium salt (Sodium valproate) supplier is an individual or a company that provides Valproic acid sodium salt (Sodium valproate) active pharmaceutical ingredient (API) or Valproic acid sodium salt (Sodium valproate) finished formulations upon request. The Valproic acid sodium salt (Sodium valproate) suppliers may include Valproic acid sodium salt (Sodium valproate) API manufacturers, exporters, distributors and traders.

    click here to find a list of Valproic acid sodium salt (Sodium valproate) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Valproic acid sodium salt (Sodium valproate) USDMF

    A Valproic acid sodium salt (Sodium valproate) DMF (Drug Master File) is a document detailing the whole manufacturing process of Valproic acid sodium salt (Sodium valproate) active pharmaceutical ingredient (API) in detail. Different forms of Valproic acid sodium salt (Sodium valproate) DMFs exist exist since differing nations have different regulations, such as Valproic acid sodium salt (Sodium valproate) USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Valproic acid sodium salt (Sodium valproate) DMF submitted to regulatory agencies in the US is known as a USDMF. Valproic acid sodium salt (Sodium valproate) USDMF includes data on Valproic acid sodium salt (Sodium valproate)'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Valproic acid sodium salt (Sodium valproate) USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Valproic acid sodium salt (Sodium valproate) suppliers with USDMF on PharmaCompass.

    Valproic acid sodium salt (Sodium valproate) JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Valproic acid sodium salt (Sodium valproate) Drug Master File in Japan (Valproic acid sodium salt (Sodium valproate) JDMF) empowers Valproic acid sodium salt (Sodium valproate) API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Valproic acid sodium salt (Sodium valproate) JDMF during the approval evaluation for pharmaceutical products. At the time of Valproic acid sodium salt (Sodium valproate) JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Valproic acid sodium salt (Sodium valproate) suppliers with JDMF on PharmaCompass.

    Valproic acid sodium salt (Sodium valproate) KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Valproic acid sodium salt (Sodium valproate) Drug Master File in Korea (Valproic acid sodium salt (Sodium valproate) KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Valproic acid sodium salt (Sodium valproate). The MFDS reviews the Valproic acid sodium salt (Sodium valproate) KDMF as part of the drug registration process and uses the information provided in the Valproic acid sodium salt (Sodium valproate) KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Valproic acid sodium salt (Sodium valproate) KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Valproic acid sodium salt (Sodium valproate) API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Valproic acid sodium salt (Sodium valproate) suppliers with KDMF on PharmaCompass.

    Valproic acid sodium salt (Sodium valproate) CEP

    A Valproic acid sodium salt (Sodium valproate) CEP of the European Pharmacopoeia monograph is often referred to as a Valproic acid sodium salt (Sodium valproate) Certificate of Suitability (COS). The purpose of a Valproic acid sodium salt (Sodium valproate) CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Valproic acid sodium salt (Sodium valproate) EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Valproic acid sodium salt (Sodium valproate) to their clients by showing that a Valproic acid sodium salt (Sodium valproate) CEP has been issued for it. The manufacturer submits a Valproic acid sodium salt (Sodium valproate) CEP (COS) as part of the market authorization procedure, and it takes on the role of a Valproic acid sodium salt (Sodium valproate) CEP holder for the record. Additionally, the data presented in the Valproic acid sodium salt (Sodium valproate) CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Valproic acid sodium salt (Sodium valproate) DMF.

    A Valproic acid sodium salt (Sodium valproate) CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Valproic acid sodium salt (Sodium valproate) CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Valproic acid sodium salt (Sodium valproate) suppliers with CEP (COS) on PharmaCompass.

    Valproic acid sodium salt (Sodium valproate) WC

    A Valproic acid sodium salt (Sodium valproate) written confirmation (Valproic acid sodium salt (Sodium valproate) WC) is an official document issued by a regulatory agency to a Valproic acid sodium salt (Sodium valproate) manufacturer, verifying that the manufacturing facility of a Valproic acid sodium salt (Sodium valproate) active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Valproic acid sodium salt (Sodium valproate) APIs or Valproic acid sodium salt (Sodium valproate) finished pharmaceutical products to another nation, regulatory agencies frequently require a Valproic acid sodium salt (Sodium valproate) WC (written confirmation) as part of the regulatory process.

    click here to find a list of Valproic acid sodium salt (Sodium valproate) suppliers with Written Confirmation (WC) on PharmaCompass.

    Valproic acid sodium salt (Sodium valproate) NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Valproic acid sodium salt (Sodium valproate) as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Valproic acid sodium salt (Sodium valproate) API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Valproic acid sodium salt (Sodium valproate) as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Valproic acid sodium salt (Sodium valproate) and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Valproic acid sodium salt (Sodium valproate) NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Valproic acid sodium salt (Sodium valproate) suppliers with NDC on PharmaCompass.

    Valproic acid sodium salt (Sodium valproate) GMP

    Valproic acid sodium salt (Sodium valproate) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Valproic acid sodium salt (Sodium valproate) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Valproic acid sodium salt (Sodium valproate) GMP manufacturer or Valproic acid sodium salt (Sodium valproate) GMP API supplier for your needs.

    Valproic acid sodium salt (Sodium valproate) CoA

    A Valproic acid sodium salt (Sodium valproate) CoA (Certificate of Analysis) is a formal document that attests to Valproic acid sodium salt (Sodium valproate)'s compliance with Valproic acid sodium salt (Sodium valproate) specifications and serves as a tool for batch-level quality control.

    Valproic acid sodium salt (Sodium valproate) CoA mostly includes findings from lab analyses of a specific batch. For each Valproic acid sodium salt (Sodium valproate) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Valproic acid sodium salt (Sodium valproate) may be tested according to a variety of international standards, such as European Pharmacopoeia (Valproic acid sodium salt (Sodium valproate) EP), Valproic acid sodium salt (Sodium valproate) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Valproic acid sodium salt (Sodium valproate) USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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