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Chemistry

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Also known as: Sodium 2-propylpentanoate, 1069-66-5, Valproate sodium, Valproic acid sodium salt, Valproic acid sodium, Depacon
Molecular Formula
C8H15NaO2
Molecular Weight
166.19  g/mol
InChI Key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
FDA UNII
5VOM6GYJ0D

Sodium Valproate
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
1 2D Structure

Sodium Valproate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;2-propylpentanoate
2.1.2 InChI
InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
2.1.3 InChI Key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CCCC(CCC)C(=O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
5VOM6GYJ0D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2 Propylpentanoic Acid

2. 2-propylpentanoic Acid

3. Calcium Valproate

4. Convulsofin

5. Depakene

6. Depakine

7. Depakote

8. Dipropyl Acetate

9. Divalproex

10. Divalproex Sodium

11. Ergenyl

12. Magnesium Valproate

13. Propylisopropylacetic Acid

14. Semisodium Valproate

15. Valproate

16. Valproate Calcium

17. Valproate Sodium

18. Valproic Acid

19. Valproic Acid, Sodium Salt (2:1)

20. Vupral

2.3.2 Depositor-Supplied Synonyms

1. Sodium 2-propylpentanoate

2. 1069-66-5

3. Valproate Sodium

4. Valproic Acid Sodium Salt

5. Valproic Acid Sodium

6. Depacon

7. Sodium 2-propylvalerate

8. Epilim

9. Valproic Acid, Sodium Salt

10. Pentanoic Acid, 2-propyl-, Sodium Salt

11. 2-propylvaleric Acid Sodium Salt

12. Valerin

13. 2-propylpentanoic Acid Sodium Salt

14. Valproic Acid Sodium Salt (1:1)

15. Valproic Acid (sodium Salt)

16. Selenica

17. Abbott 44090

18. Valproate Sodium [usan]

19. Valproate

20. Valproic Acid, Sodium

21. Valproic Acid Sodium Salt (sodium Valproate)

22. Sodium;2-propylpentanoate

23. Mfcd00078604

24. 5vom6gyj0d

25. Abbott-44090

26. Chebi:9925

27. Eurekene

28. Labazene

29. Orfiril

30. Kw-6066n

31. Nsc-732626

32. Nsc-757376

33. Depakene (tn)

34. Natrium Valproat

35. Valproate Sodium (usan)

36. A-44090

37. Dipropylacetate Sodium

38. Sodium Dipropylacetate

39. Sodium Bispropylacetate

40. Chembl433

41. Valproinsaeure, Natrium

42. Sodium N-dipropylacetate

43. 2-propylpentanoic Acid Sodium

44. Smr000875243

45. Sodium 2-n-propyl-pentanoate

46. Kw 6066n

47. Einecs 213-961-8

48. Unii-5vom6gyj0d

49. Valeric Acid, 2-propyl-, Sodium Salt

50. Natrii Valproas

51. Valproate Sodium [usan:usp]

52. Valproicacidsodium

53. Selenica (tn)

54. Valproic Acid (sodium)

55. Lopac-p-4543

56. Sodium Valproate (jp17)

57. Dsstox_cid_17072

58. Dsstox_rid_79301

59. Dsstox_gsid_37072

60. Schembl35027

61. Mls001332431

62. Mls001332432

63. Mls002153189

64. Spectrum1500606

65. Sodium Valproate [jan]

66. Dtxsid5037072

67. Valproate Sodium [vandf]

68. Hms500n15

69. Valproic Acid Sodium Salt, 98%

70. Sodium Valproate [mart.]

71. Sodium Valproate [who-ip]

72. Valproate Sodium [who-dd]

73. Hms1921i21

74. Hms2092c12

75. Hms2230e16

76. Hms3262b20

77. Hms3369l11

78. Hms3648a12

79. Hms3654i14

80. Hms3872g13

81. Hms3884e05

82. Bcp02888

83. Tox21_302623

84. Tox21_500889

85. Ccg-40071

86. Hy-10585a

87. S1168

88. 2-propyl-pentanoic Acid, Sodium Salt

89. Akos005066057

90. Valproate Sodium [orange Book]

91. Ac-8391

92. Ccg-208088

93. Ccg-266330

94. Cs-1764

95. Lp00889

96. Natrii Valproas [who-ip Latin]

97. Nsc 732626

98. Nsc 757376

99. Sodium Valproate [ep Monograph]

100. Valproate Sodium [usp Impurity]

101. Ncgc00016192-01

102. Ncgc00016192-02

103. Ncgc00016192-03

104. Ncgc00016192-04

105. Ncgc00094208-01

106. Ncgc00094208-02

107. Ncgc00094208-03

108. Ncgc00167849-01

109. Ncgc00256651-01

110. Ncgc00261574-01

111. As-13150

112. Sy058189

113. 2-propylpentanoic Acid Sodium Salt (1:1)

114. Bcp0726000316

115. Cas-1069-66-5

116. Db-059527

117. Sodium 2-propylpentanoate [who-ip]

118. Eu-0100889

119. Ft-0633278

120. S0894

121. Sw219169-2

122. D00710

123. H11308

124. P 4543

125. Valproic Acid Sodium Salt (1:1) [mi]

126. Pentanoic Acid, 2-propyl-, Sodium Salt (1:1)

127. Valproic Acid, Sodium Salt - Cas 1069-66-5

128. Q-201918

129. Q4347890

130. Sodium Valproate, British Pharmacopoeia (bp) Reference Standard

131. Sodium Valproate, European Pharmacopoeia (ep) Reference Standard

132. Sodium Valproate, 2-propylpentanoic Acid . Na, Sodium 2-propylpentanoate

2.4 Create Date
2007-11-13
3 Chemical and Physical Properties
Molecular Weight 166.19 g/mol
Molecular Formula C8H15NaO2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass166.09697400 g/mol
Monoisotopic Mass166.09697400 g/mol
Topological Polar Surface Area40.1 Ų
Heavy Atom Count11
Formal Charge0
Complexity98.3
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameDepacon
PubMed HealthValproate Sodium (Injection)
Drug ClassesAnticonvulsant
Drug LabelDepacon (valproate sodium) is the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, cry...
Active IngredientValproate sodium
Dosage FormInjectable
RouteInjection
Strengtheq 100mg base/ml
Market StatusPrescription
CompanyAbbvie

2 of 4  
Drug NameValproate sodium
PubMed HealthValproate Sodium (Injection)
Drug ClassesAnticonvulsant
Drug LabelValproate sodium injection, USPis the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorles...
Active IngredientValproate sodium
Dosage FormInjectable
RouteInjection
Strengtheq 100mg base/ml
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; Fresenius Kabi Usa

3 of 4  
Drug NameDepacon
PubMed HealthValproate Sodium (Injection)
Drug ClassesAnticonvulsant
Drug LabelDepacon (valproate sodium) is the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, cry...
Active IngredientValproate sodium
Dosage FormInjectable
RouteInjection
Strengtheq 100mg base/ml
Market StatusPrescription
CompanyAbbvie

4 of 4  
Drug NameValproate sodium
PubMed HealthValproate Sodium (Injection)
Drug ClassesAnticonvulsant
Drug LabelValproate sodium injection, USPis the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorles...
Active IngredientValproate sodium
Dosage FormInjectable
RouteInjection
Strengtheq 100mg base/ml
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; Fresenius Kabi Usa

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


Antimanic Agents

Agents that are used to treat bipolar disorders or mania associated with other affective disorders. (See all compounds classified as Antimanic Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


GABA Agents

Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as GABA Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Decreased Central Nervous System Disorganized Electrical Activity [PE]; Mood Stabilizer [EPC]; Anti-epileptic Agent [EPC]

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31-Mar-2025
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Looking for 1069-66-5 / Sodium Valproate API manufacturers, exporters & distributors?

Sodium Valproate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sodium Valproate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Valproate manufacturer or Sodium Valproate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium Valproate manufacturer or Sodium Valproate supplier.

PharmaCompass also assists you with knowing the Sodium Valproate API Price utilized in the formulation of products. Sodium Valproate API Price is not always fixed or binding as the Sodium Valproate Price is obtained through a variety of data sources. The Sodium Valproate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sodium Valproate

Synonyms

Sodium 2-propylpentanoate, 1069-66-5, Valproate sodium, Valproic acid sodium salt, Valproic acid sodium, Depacon

Cas Number

1069-66-5

Unique Ingredient Identifier (UNII)

5VOM6GYJ0D

About Sodium Valproate

A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.

Valproate Sodium Manufacturers

A Valproate Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Valproate Sodium, including repackagers and relabelers. The FDA regulates Valproate Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Valproate Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Valproate Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Valproate Sodium Suppliers

A Valproate Sodium supplier is an individual or a company that provides Valproate Sodium active pharmaceutical ingredient (API) or Valproate Sodium finished formulations upon request. The Valproate Sodium suppliers may include Valproate Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Valproate Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Valproate Sodium USDMF

A Valproate Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Valproate Sodium active pharmaceutical ingredient (API) in detail. Different forms of Valproate Sodium DMFs exist exist since differing nations have different regulations, such as Valproate Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Valproate Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Valproate Sodium USDMF includes data on Valproate Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Valproate Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Valproate Sodium suppliers with USDMF on PharmaCompass.

Valproate Sodium JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Valproate Sodium Drug Master File in Japan (Valproate Sodium JDMF) empowers Valproate Sodium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Valproate Sodium JDMF during the approval evaluation for pharmaceutical products. At the time of Valproate Sodium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Valproate Sodium suppliers with JDMF on PharmaCompass.

Valproate Sodium KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Valproate Sodium Drug Master File in Korea (Valproate Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Valproate Sodium. The MFDS reviews the Valproate Sodium KDMF as part of the drug registration process and uses the information provided in the Valproate Sodium KDMF to evaluate the safety and efficacy of the drug.

After submitting a Valproate Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Valproate Sodium API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Valproate Sodium suppliers with KDMF on PharmaCompass.

Valproate Sodium CEP

A Valproate Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Valproate Sodium Certificate of Suitability (COS). The purpose of a Valproate Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Valproate Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Valproate Sodium to their clients by showing that a Valproate Sodium CEP has been issued for it. The manufacturer submits a Valproate Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Valproate Sodium CEP holder for the record. Additionally, the data presented in the Valproate Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Valproate Sodium DMF.

A Valproate Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Valproate Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Valproate Sodium suppliers with CEP (COS) on PharmaCompass.

Valproate Sodium WC

A Valproate Sodium written confirmation (Valproate Sodium WC) is an official document issued by a regulatory agency to a Valproate Sodium manufacturer, verifying that the manufacturing facility of a Valproate Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Valproate Sodium APIs or Valproate Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Valproate Sodium WC (written confirmation) as part of the regulatory process.

click here to find a list of Valproate Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

Valproate Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Valproate Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Valproate Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Valproate Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Valproate Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Valproate Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Valproate Sodium suppliers with NDC on PharmaCompass.

Valproate Sodium GMP

Valproate Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Valproate Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Valproate Sodium GMP manufacturer or Valproate Sodium GMP API supplier for your needs.

Valproate Sodium CoA

A Valproate Sodium CoA (Certificate of Analysis) is a formal document that attests to Valproate Sodium's compliance with Valproate Sodium specifications and serves as a tool for batch-level quality control.

Valproate Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Valproate Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Valproate Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Valproate Sodium EP), Valproate Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Valproate Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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