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Chemistry

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Also known as: 69-93-2, Urate, Lithic acid, 2,6,8-trioxypurine, 2,6,8-trihydroxypurine, 8-hydroxyxanthine
Molecular Formula
C5H4N4O3
Molecular Weight
168.11  g/mol
InChI Key
LEHOTFFKMJEONL-UHFFFAOYSA-N
FDA UNII
268B43MJ25

Uric Acid
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
1 2D Structure

Uric Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7,9-dihydro-3H-purine-2,6,8-trione
2.1.2 InChI
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
2.1.3 InChI Key
LEHOTFFKMJEONL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C12=C(NC(=O)N1)NC(=O)NC2=O
2.2 Other Identifiers
2.2.1 UNII
268B43MJ25
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2,6,8-trihydroxypurine

2. Acid Urate, Ammonium

3. Acid Urate, Sodium

4. Acid, Uric

5. Ammonium Acid Urate

6. Monohydrate, Monosodium Urate

7. Monohydrate, Sodium Urate

8. Monosodium Urate

9. Monosodium Urate Monohydrate

10. Potassium Urate

11. Sodium Acid Urate

12. Sodium Acid Urate Monohydrate

13. Sodium Urate

14. Sodium Urate Monohydrate

15. Trioxopurine

16. Urate

17. Urate Monohydrate, Monosodium

18. Urate Monohydrate, Sodium

19. Urate, Ammonium Acid

20. Urate, Monosodium

21. Urate, Potassium

22. Urate, Sodium

23. Urate, Sodium Acid

2.3.2 Depositor-Supplied Synonyms

1. 69-93-2

2. Urate

3. Lithic Acid

4. 2,6,8-trioxypurine

5. 2,6,8-trihydroxypurine

6. 8-hydroxyxanthine

7. 7,9-dihydro-1h-purine-2,6,8(3h)-trione

8. 2,6,8-trioxopurine

9. 1h-purine-2,6,8-triol

10. 1h-purine-2,6,8(3h)-trione, 7,9-dihydro-

11. Purine-2,6,8(1h,3h,9h)-trione

12. 7,9-dihydro-3h-purine-2,6,8-trione

13. Uricum Acidum

14. Ai3-15432

15. 2,3,6,7,8,9-hexahydro-1h-purine-2,6,8-trione

16. Nsc 3975

17. 1h-purine-2,6,8(3h,7h,9h)-trione

18. Nsc-3975

19. Mfcd00005712

20. Idelalisib Metabolite M54

21. Chembl792

22. 9h-purine-2,6,8-triol

23. Chebi:17775

24. 268b43mj25

25. 2,6-dihydroxy-7,9-dihydropurin-8-one

26. Ncgc00181032-01

27. 8-hydroxy-3,9-dihydro-1h-purine-2,6-dione

28. 6,8-dioxo-6,7,8,9-tetrahydro-1h-purin-2-olate

29. Trioxopurine

30. Urc

31. Einecs 200-720-7

32. Lithate

33. Hypoxanthinediol

34. Uric-acid

35. Unii-268b43mj25

36. 2,8-trioxopurine

37. 2,8-trioxypurine

38. 8hx

39. Uric Acid (8ci)

40. 2,8-trihydroxypurine

41. 1l5s

42. 2,6,8-trihydroxypurin

43. Purine-2,6,8-triol

44. 1h-purine-2,8-triol

45. Uric Acid, 99.0%

46. Uric Acid [mi]

47. Uric Acid [inci]

48. Bmse000126

49. Schembl7933

50. 7h-purine-2,6,8-triol

51. Dsstox_cid_22508

52. Dsstox_rid_80044

53. Dsstox_gsid_42508

54. Uricum Acidum [hpus]

55. (s)-3-aminoquinuclidine Hcl

56. Gtpl4731

57. Dtxsid3042508

58. Schembl15777793

59. Schembl17081907

60. Chebi:46811

61. Chebi:46814

62. Chebi:46817

63. Chebi:46823

64. Chebi:62589

65. Nsc3975

66. Uric Acid, >=99%, Crystalline

67. Hms3604n17

68. Amy23430

69. Bcp28980

70. Hy-b2130

71. Purine-2,8(1h,3h,9h)-trione

72. Zinc2041003

73. Tox21_113563

74. Bdbm50325824

75. S3955

76. Stl185577

77. Akos000118731

78. Purine-3,6,8(1h,3h,9h)-trione

79. Ccg-339700

80. Db08844

81. Uric Acid, Nist(r) Srm(r) 913b

82. Cas-69-93-2

83. Purine-2,6,8-(1h,3h,9h)-trione

84. Uric Acid, Bioxtra, >=99% (hplc)

85. As-56119

86. Sy057305

87. 6-hydroxy-1h-purine-2,8(7h,9h)-dione

88. Db-055359

89. 2,6,8-trioxypurine;2,6,8-trihydroxypurine

90. 2,6-dihydroxy-7,9-dihydro-8h-purin-8-one

91. Cs-0020287

92. Ft-0631301

93. U0018

94. 1h-purine-2,8(3h)-trione, 7,9-dihydro-

95. 7,9-dihydro-3h-purine-2,6,8-trione(urate)

96. C00366

97. U-6050

98. 1h-purine-2,6,8-triol 2,6,8-trihydroxypurine

99. 7,9-dihydro-3h-purine-2,6,8-trione(uric Acid)

100. A866713

101. Q105522

102. Sr-01000945208

103. Sr-01000945208-1

104. 565ff3af-8afa-4ee9-9fc4-6b119784a5bb

105. 1h-purine-2,6,8(3h)-trione, 7,9-dihydro- (9ci)

106. Z1318255135

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 168.11 g/mol
Molecular Formula C5H4N4O3
XLogP3-1.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass168.02834000 g/mol
Monoisotopic Mass168.02834000 g/mol
Topological Polar Surface Area99.3 Ų
Heavy Atom Count12
Formal Charge0
Complexity332
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Uric acid is a strong reducing agent (donates electrons) and an antioxidant. Normally in humans, one of the main antioxidants in plasma is uric acid. Several animal studies have found that animals given exogenous uric acid within 3 hours after a stroke had decreased infarct volume, improved neurologic function, and diminished inflammatory responses providing evidence for the neuroprotective effects of uric acid. In some early human studies, uric acid has so far shown similar neuroprotective effects, in both the cortex and subcortex areas, due to its antioxidant effects such as decreased lipid peroxidation, and there appears to be no significant toxicities.


5.2 MeSH Pharmacological Classification

Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)


5.3 Absorption, Distribution and Excretion

Route of Elimination

Uric acid is eliminated by the kidneys.


5.4 Metabolism/Metabolites

In higher primates and humans, the enzyme, uricase, is absent, and thus uric acid is not further metabolized and is excreted. In all other mammals, uric acid is metabolized by uricase to allantoin, which is then excreted.


5.5 Mechanism of Action

The exact mechanism of action for uric acid's antioxidant effects have not yet been elucidated.


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ABOUT THIS PAGE

Looking for 69-93-2 / Uric Acid API manufacturers, exporters & distributors?

Uric Acid manufacturers, exporters & distributors 1

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API | Excipient name

Uric Acid

Synonyms

69-93-2, Urate, Lithic acid, 2,6,8-trioxypurine, 2,6,8-trihydroxypurine, 8-hydroxyxanthine

Cas Number

69-93-2

Unique Ingredient Identifier (UNII)

268B43MJ25

About Uric Acid

An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.

Uric Acid Manufacturers

A Uric Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Uric Acid, including repackagers and relabelers. The FDA regulates Uric Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Uric Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Uric Acid Suppliers

A Uric Acid supplier is an individual or a company that provides Uric Acid active pharmaceutical ingredient (API) or Uric Acid finished formulations upon request. The Uric Acid suppliers may include Uric Acid API manufacturers, exporters, distributors and traders.

click here to find a list of Uric Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

Uric Acid USDMF

A Uric Acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Uric Acid active pharmaceutical ingredient (API) in detail. Different forms of Uric Acid DMFs exist exist since differing nations have different regulations, such as Uric Acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Uric Acid DMF submitted to regulatory agencies in the US is known as a USDMF. Uric Acid USDMF includes data on Uric Acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Uric Acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Uric Acid suppliers with USDMF on PharmaCompass.

Uric Acid GMP

Uric Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Uric Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Uric Acid GMP manufacturer or Uric Acid GMP API supplier for your needs.

Uric Acid CoA

A Uric Acid CoA (Certificate of Analysis) is a formal document that attests to Uric Acid's compliance with Uric Acid specifications and serves as a tool for batch-level quality control.

Uric Acid CoA mostly includes findings from lab analyses of a specific batch. For each Uric Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Uric Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Uric Acid EP), Uric Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Uric Acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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