Find Uprosertib manufacturers, exporters & distributors on PharmaCompass

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Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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Chemistry

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Also known as: 1047634-65-0, Gsk2141795, Gsk2141795c, Gsk795, Gsk-2141795, Zxm835lq5e
Molecular Formula
C18H16Cl2F2N4O2
Molecular Weight
429.2  g/mol
InChI Key
AXTAPYRUEKNRBA-JTQLQIEISA-N
FDA UNII
ZXM835LQ5E

Uprosertib
Uprosertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Uprosertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
1 2D Structure

Uprosertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide
2.1.2 InChI
InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
2.1.3 InChI Key
AXTAPYRUEKNRBA-JTQLQIEISA-N
2.1.4 Canonical SMILES
CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl
2.1.5 Isomeric SMILES
CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)N[C@@H](CC3=CC(=C(C=C3)F)F)CN)Cl
2.2 Other Identifiers
2.2.1 UNII
ZXM835LQ5E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Gsk2141795

2.3.2 Depositor-Supplied Synonyms

1. 1047634-65-0

2. Gsk2141795

3. Gsk2141795c

4. Gsk795

5. Gsk-2141795

6. Zxm835lq5e

7. Akt Inhibitor Gsk2141795

8. Akt Inhibitor Gsk-2141795

9. Uprosertib (gsk2141795)

10. Gsk-2141795c

11. N-((s)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)furan-2-carboxamide

12. 2-furancarboxamide, N-((1s)-2-amino-1-((3,4-difluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-

13. N-((1s)-1-(aminomethyl)-2-(3,4-difluorophenyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)furan-2-carboxamide

14. N-[(2s)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide

15. Uprosertib [usan:inn]

16. Unii-zxm835lq5e

17. Uprosertib [usan]

18. Uprosertib [inn]

19. Uprosertib (usan/inn)

20. Uprosertib [who-dd]

21. Schembl168584

22. Uprosertib, Gsk2141795

23. Gtpl7902

24. Chembl3137336

25. Bcp28204

26. Ex-a1593

27. Bdbm50170284

28. Mfcd28144686

29. Nsc778368

30. Nsc800960

31. S7492

32. Zinc43197676

33. Akos027323909

34. Ccg-268992

35. Db11969

36. Nsc-778368

37. Nsc-800960

38. Ncgc00390653-01

39. Ac-30940

40. Hy-15965

41. D10674

42. F20800

43. Q27089099

44. Gsk-2141795; Gsk2141795; Gsk 2141795; Gsk795; Gsk-795; Gsk 795.

45. (s)-n-(1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)furan-2-carboxamide

46. N-{(1s)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-furancarboxamide

2.4 Create Date
2011-04-25
3 Chemical and Physical Properties
Molecular Weight 429.2 g/mol
Molecular Formula C18H16Cl2F2N4O2
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass428.0618375 g/mol
Monoisotopic Mass428.0618375 g/mol
Topological Polar Surface Area86.1 Ų
Heavy Atom Count28
Formal Charge0
Complexity550
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1047634-65-0 / Uprosertib API manufacturers, exporters & distributors?

Uprosertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Uprosertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Uprosertib manufacturer or Uprosertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Uprosertib manufacturer or Uprosertib supplier.

PharmaCompass also assists you with knowing the Uprosertib API Price utilized in the formulation of products. Uprosertib API Price is not always fixed or binding as the Uprosertib Price is obtained through a variety of data sources. The Uprosertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Uprosertib

Synonyms

1047634-65-0, Gsk2141795, Gsk2141795c, Gsk795, Gsk-2141795, Zxm835lq5e

Cas Number

1047634-65-0

Unique Ingredient Identifier (UNII)

ZXM835LQ5E

About Uprosertib

Uprosertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Uprosertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Uprosertib Manufacturers

A Uprosertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Uprosertib, including repackagers and relabelers. The FDA regulates Uprosertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Uprosertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Uprosertib Suppliers

A Uprosertib supplier is an individual or a company that provides Uprosertib active pharmaceutical ingredient (API) or Uprosertib finished formulations upon request. The Uprosertib suppliers may include Uprosertib API manufacturers, exporters, distributors and traders.

Uprosertib GMP

Uprosertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Uprosertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Uprosertib GMP manufacturer or Uprosertib GMP API supplier for your needs.

Uprosertib CoA

A Uprosertib CoA (Certificate of Analysis) is a formal document that attests to Uprosertib's compliance with Uprosertib specifications and serves as a tool for batch-level quality control.

Uprosertib CoA mostly includes findings from lab analyses of a specific batch. For each Uprosertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Uprosertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Uprosertib EP), Uprosertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Uprosertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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