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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 211427-08-6, Ins365, Up4u, Diquafosol sodium, Kpy-998, De-089
Molecular Formula
C18H22N4Na4O23P4
Molecular Weight
878.2  g/mol
InChI Key
OWTGMPPCCUSXIP-FNXFGIETSA-J
FDA UNII
X8T9SBH9LL

Diquafosol
1 2D Structure

Diquafosol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
tetrasodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
2.1.2 InChI
InChI=1S/C18H26N4O23P4.4Na/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30;;;;/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30);;;;/q;4*+1/p-4/t7-,8-,11-,12-,13-,14-,15-,16-;;;;/m1..../s1
2.1.3 InChI Key
OWTGMPPCCUSXIP-FNXFGIETSA-J
2.1.4 Canonical SMILES
C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O.[Na+].[Na+].[Na+].[Na+]
2.1.5 Isomeric SMILES
C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=CC(=O)NC4=O)O)O)O)O.[Na+].[Na+].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
X8T9SBH9LL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Diquafosol

2. Ins 365

3. Ins-365

4. Ins365

2.3.2 Depositor-Supplied Synonyms

1. 211427-08-6

2. Ins365

3. Up4u

4. Diquafosol Sodium

5. Kpy-998

6. De-089

7. X8t9sbh9ll

8. Diquafosol Tetrasodium Salt

9. Diquafosol Tetrasodium [usan]

10. Diquafosol Sodium (jan)

11. Tetrasodium;[[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] Phosphate

12. Diquafosol Tetrasodium (usan)

13. Uridine(5')tetraphospho(5')uridine Tetrasodium Salt

14. Diquafosol (tetrasodium)

15. Diquafosol Sodium [jan]

16. Chembl1767408

17. Ins-365

18. Prolacria

19. Diquas

20. Unii-x8t9sbh9ll

21. Ins365 Ophthalmic Solution

22. U2p4

23. Ex-a6122

24. Diquafosol Tetrasodium [mart.]

25. Diquafosol Tetrasodium [who-dd]

26. Diquafosol Tetrasodium Salt [mi]

27. Ac-36639

28. D03864

29. A900791

30. P1,p4-diuridine 5'-tetraphosphate Tetrasodium Salt

31. Q27293698

32. Uridine 5'-(pentahydrogen Tetraphosphate), P'''-5'ester With Uridine, Tetrasodium Salt

33. Uridine, 5'-(pentahydrogen Tetraphosphate), P'''-5'-ester With Uridine, Tetrasodium Salt

34. Uridine, 5'-(pentahydrogen Tetraphosphate), P''' ->5'-ester With Uridine, Tetrasodium Salt

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 878.2 g/mol
Molecular Formula C18H22N4Na4O23P4
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count23
Rotatable Bond Count14
Exact Mass877.9216081 g/mol
Monoisotopic Mass877.9216081 g/mol
Topological Polar Surface Area405 Ų
Heavy Atom Count53
Formal Charge0
Complexity1460
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count5

API Reference Price

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04-Jan-2025
13-Mar-2025
KGS
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Diquafosol manufacturers, exporters & distributors 1

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API | Excipient name

Diquafosol

Synonyms

211427-08-6, Ins365, Up4u, Diquafosol sodium, Kpy-998, De-089

Cas Number

211427-08-6

Unique Ingredient Identifier (UNII)

X8T9SBH9LL

U2P4 Manufacturers

A U2P4 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of U2P4, including repackagers and relabelers. The FDA regulates U2P4 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. U2P4 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of U2P4 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

U2P4 Suppliers

A U2P4 supplier is an individual or a company that provides U2P4 active pharmaceutical ingredient (API) or U2P4 finished formulations upon request. The U2P4 suppliers may include U2P4 API manufacturers, exporters, distributors and traders.

click here to find a list of U2P4 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

U2P4 USDMF

A U2P4 DMF (Drug Master File) is a document detailing the whole manufacturing process of U2P4 active pharmaceutical ingredient (API) in detail. Different forms of U2P4 DMFs exist exist since differing nations have different regulations, such as U2P4 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A U2P4 DMF submitted to regulatory agencies in the US is known as a USDMF. U2P4 USDMF includes data on U2P4's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The U2P4 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of U2P4 suppliers with USDMF on PharmaCompass.

U2P4 GMP

U2P4 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of U2P4 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right U2P4 GMP manufacturer or U2P4 GMP API supplier for your needs.

U2P4 CoA

A U2P4 CoA (Certificate of Analysis) is a formal document that attests to U2P4's compliance with U2P4 specifications and serves as a tool for batch-level quality control.

U2P4 CoA mostly includes findings from lab analyses of a specific batch. For each U2P4 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

U2P4 may be tested according to a variety of international standards, such as European Pharmacopoeia (U2P4 EP), U2P4 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (U2P4 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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