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Chemistry

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Also known as: Pivalone, Tixocortol 21-pivalate, 55560-96-8, Jo 1016, Tixocortol pivalate [usan], Jo-1016
Molecular Formula
C26H38O5S
Molecular Weight
462.6  g/mol
InChI Key
BISFDZNIUZIKJD-XDANTLIUSA-N
FDA UNII
6K28E35M3B

Tixocortol Pivalate
Tixocortol pivalate is a Standardized Chemical Allergen. The physiologic effect of tixocortol pivalate is by means of Increased Histamine Release, and Cell-mediated Immunity.
1 2D Structure

Tixocortol Pivalate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
S-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanethioate
2.1.2 InChI
InChI=1S/C26H38O5S/c1-23(2,3)22(30)32-14-20(29)26(31)11-9-18-17-7-6-15-12-16(27)8-10-24(15,4)21(17)19(28)13-25(18,26)5/h12,17-19,21,28,31H,6-11,13-14H2,1-5H3/t17-,18-,19-,21+,24-,25-,26-/m0/s1
2.1.3 InChI Key
BISFDZNIUZIKJD-XDANTLIUSA-N
2.1.4 Canonical SMILES
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CSC(=O)C(C)(C)C)O)C)O
2.1.5 Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CSC(=O)C(C)(C)C)O)C)O
2.2 Other Identifiers
2.2.1 UNII
6K28E35M3B
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 11 Beta,17-dihydroxy-21-mercaptopregn-4-ene-3,20-dione Pivalate

2. Jo 1016

3. Jo-1016

4. Pivalone

5. Tiovalone

2.3.2 Depositor-Supplied Synonyms

1. Pivalone

2. Tixocortol 21-pivalate

3. 55560-96-8

4. Jo 1016

5. Tixocortol Pivalate [usan]

6. Jo-1016

7. Chebi:63564

8. Tixocortol-21-pivalate

9. 11beta,17-dihydroxy-21-mercaptopregn-4-ene-3,20-dione 21-pivalate

10. 6k28e35m3b

11. Tixocortol Pivalate (usan)

12. (11beta)-11,17-dihydroxy-21-((2,2-dimethyl-1-oxopropyl)thio)pregn-4-ene-3,20-dione

13. S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate)

14. S-(11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl) 2,2-dimethylpropanethioate

15. S-(2-((8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl) 2,2-dimethylpropanethioate

16. Unii-6k28e35m3b

17. S-(11beta,17-dihydroxypregn-4-ene-3,20-dione) 21-(thiopivalate)

18. Einecs 259-706-4

19. Epitope Id:161747

20. Schembl6827

21. Chembl2107112

22. Dtxsid30970904

23. Tixocortol Pivalate [vandf]

24. Tixocortol Pivalate [mart.]

25. Zinc4214485

26. Jo1016

27. Tixocortol 21-pivalate [mi]

28. Tixocortol Pivalate [who-dd]

29. Pregn-4-ene-3,20-dione, 21-((2,2-dimethyl-1-oxopropyl)thio)-11,17-dihydroxy-, (11beta)-

30. D06171

31. Q7810487

32. (11beta)-21-[(2,2-dimethyl-1-oxopropyl)thio]-11,17-dihydroxypregn-4-ene-3,20-dione

33. 11.beta.,17-dihydroxy-21-mercaptopregn-4-ene-3,20-dione 21-pivalate

34. S-(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl) 2,2-dimethylpropanethioate

35. Pregn-4-ene-3,20-dione, 21-((2,2-dimethyl-1-oxopropyl)thio)-11,17-dihydroxy-, (11.beta.)-

36. S-[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanethioate

2.4 Create Date
2007-02-09
3 Chemical and Physical Properties
Molecular Weight 462.6 g/mol
Molecular Formula C26H38O5S
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass462.24399548 g/mol
Monoisotopic Mass462.24399548 g/mol
Topological Polar Surface Area117 Ų
Heavy Atom Count32
Formal Charge0
Complexity872
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)


4.2 FDA Pharmacological Classification
4.2.1 Active Moiety
TIXOCORTOL PIVALATE
4.2.2 FDA UNII
6K28E35M3B
4.2.3 Pharmacological Classes
Chemical Structure [CS] - Allergens

FDF Dossiers

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01

Country
Breast Cancer
Not Confirmed
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Country
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Breast Cancer
Not Confirmed

Tixocortoli-21-pivalas; Neomycinum

Brand Name : Pivalone Compositum

Dosage Form : Nasal Spray

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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Europe

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F. Uhlmann-Eyraud SA

Country
BioProcess International Europe
Not Confirmed
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F. Uhlmann-Eyraud SA

Country
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BioProcess International Europe
Not Confirmed

Tixocortoli-21-pivalas; Neomycinum

Brand Name : Pivalone Compositum

Dosage Form : Nasal Spray

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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ABOUT THIS PAGE

Looking for 55560-96-8 / Tixocortol Pivalate API manufacturers, exporters & distributors?

Tixocortol Pivalate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tixocortol Pivalate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tixocortol Pivalate manufacturer or Tixocortol Pivalate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tixocortol Pivalate manufacturer or Tixocortol Pivalate supplier.

PharmaCompass also assists you with knowing the Tixocortol Pivalate API Price utilized in the formulation of products. Tixocortol Pivalate API Price is not always fixed or binding as the Tixocortol Pivalate Price is obtained through a variety of data sources. The Tixocortol Pivalate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tixocortol Pivalate

Synonyms

Pivalone, Tixocortol 21-pivalate, 55560-96-8, Jo 1016, Tixocortol pivalate [usan], Jo-1016

Cas Number

55560-96-8

Unique Ingredient Identifier (UNII)

6K28E35M3B

Tixocortol Pivalate Manufacturers

A Tixocortol Pivalate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tixocortol Pivalate, including repackagers and relabelers. The FDA regulates Tixocortol Pivalate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tixocortol Pivalate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tixocortol Pivalate Suppliers

A Tixocortol Pivalate supplier is an individual or a company that provides Tixocortol Pivalate active pharmaceutical ingredient (API) or Tixocortol Pivalate finished formulations upon request. The Tixocortol Pivalate suppliers may include Tixocortol Pivalate API manufacturers, exporters, distributors and traders.

Tixocortol Pivalate GMP

Tixocortol Pivalate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tixocortol Pivalate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tixocortol Pivalate GMP manufacturer or Tixocortol Pivalate GMP API supplier for your needs.

Tixocortol Pivalate CoA

A Tixocortol Pivalate CoA (Certificate of Analysis) is a formal document that attests to Tixocortol Pivalate's compliance with Tixocortol Pivalate specifications and serves as a tool for batch-level quality control.

Tixocortol Pivalate CoA mostly includes findings from lab analyses of a specific batch. For each Tixocortol Pivalate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tixocortol Pivalate may be tested according to a variety of international standards, such as European Pharmacopoeia (Tixocortol Pivalate EP), Tixocortol Pivalate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tixocortol Pivalate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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