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    Chemistry

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    Also known as: 7553-56-2, I, Molecular iodine, Diiodine, Iodine crystals, Iodine solution
    Molecular Formula
    I2
    Molecular Weight
    253.8089  g/mol
    InChI Key
    PNDPGZBMCMUPRI-UHFFFAOYSA-N
    FDA UNII
    9679TC07X4
    Iodine
    A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
    1 2D Structure

    Iodine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    molecular iodine
    2.1.2 InChI
    InChI=1S/I2/c1-2
    2.1.3 InChI Key
    PNDPGZBMCMUPRI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    II
    2.2 Other Identifiers
    2.2.1 UNII
    9679TC07X4
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Iodine 127

    2. Iodine-127

    2.3.2 Depositor-Supplied Synonyms

    1. 7553-56-2

    2. I

    3. Molecular Iodine

    4. Diiodine

    5. Iodine Crystals

    6. Iodine Solution

    7. Iodine Sublimed

    8. Tincture Iodine

    9. Vistarin

    10. Eranol

    11. Iodio

    12. Iode

    13. Iosan Superdip

    14. Jood

    15. Iodine-127

    16. Iodine Tincture

    17. Iodine Colloidal

    18. Iodine Tincture Usp

    19. Ethanolic Solution Of Iodine

    20. Iodine ((127)i2)

    21. Jodosan

    22. Tegodyne

    23. Jod [german, Polish]

    24. Iodum

    25. I2

    26. Iodine Strong

    27. 12190-71-5

    28. Mfcd00011355

    29. Nsc-42355

    30. Jod

    31. Chebi:17606

    32. Iodine, Crystalline

    33. 9679tc07x4

    34. Iodine Solution, Wijs

    35. Actomar

    36. Iodio [italian]

    37. Jod (german, Polish)

    38. Jood [dutch]

    39. Iode [french]

    40. Iodine [jan]

    41. Caswell No. 501

    42. Diiodane

    43. Hsdb 34

    44. Iodine (resublimed)

    45. Ccris 9223

    46. Iodine [usp:jan]

    47. Einecs 231-442-4

    48. Nsc 42355

    49. Epa Pesticide Chemical Code 046905

    50. Iodine-iodide

    51. Iodonium Iodide

    52. Diatomic Iodine

    53. Iodine Mild

    54. Ai3-08544

    55. Iodine,

    56. Unii-9679tc07x4

    57. Iodine, Elemental

    58. I2i

    59. Cadex (tn)

    60. Iodine, Acs Reagent

    61. Iodine Solution, 1n

    62. Iodine-molecule

    63. Iodine Lump, Ultra Dry

    64. Iodine Solution, 5 Mm

    65. Iodine [vandf]

    66. Iodine [hsdb]

    67. Iodium [hpus]

    68. Iodine (jp17/usp)

    69. Iodine [who-dd]

    70. Iodine [who-ip]

    71. Iodine [ii]

    72. Iodine [mi]

    73. Iodine [mart.]

    74. Iodine Solution, 0.5 M

    75. Ec 231-442-4

    76. Iodine, Resublimed Crystals

    77. Dsstox_cid_14672

    78. Dsstox_rid_79188

    79. Iodine Mild [vandf]

    80. Iodine Solution, 0.05 M

    81. Dsstox_gsid_34672

    82. Iodine [ep Impurity]

    83. Iodine Solution, 5%, Lugol

    84. Iodine [ep Monograph]

    85. Iodine Strong [vandf]

    86. Iodum [who-ip Latin]

    87. Iodine [usp Monograph]

    88. Iodine 0.1n Standard Solution

    89. Chembl1201225

    90. Dtxsid7034672

    91. Iodine, 99.99% Metals Basis

    92. Iodine, Ar, >=99.8%

    93. Iodine, Lr, >=99.5%

    94. Iodine , Lugol's Solution 5%

    95. Amy39508

    96. Bcp31677

    97. Nsc42355

    98. Iodine, 1.0n Standardized Solution

    99. Tox21_301294

    100. Mfcd00164163

    101. Iodine Solution, 0.02n (n/50)

    102. Iodine, 0.01n Standardized Solution

    103. Akos015902439

    104. Iodine Spheres, Ultra Dry, -10 Mesh

    105. Db05382

    106. Iodine, 99.999% Trace Metals Basis

    107. Iodine, Saj First Grade, >=99.0%

    108. Iodine, >=99.99% Trace Metals Basis

    109. Iodine, Usp, 99.8-100.5%

    110. Iodine, Jis Special Grade, >=99.8%

    111. Iodine, Vetec(tm) Reagent Grade, 99%

    112. Ncgc00257544-01

    113. Bp-21210

    114. Iodine, Acs Reagent, >=99.8%, Solid

    115. Iodine, Reagentplus(r), >=99%, Chips

    116. Cas-7553-56-2

    117. Iodine, Purum P.a., >=99.5% (rt)

    118. Diiodine;iodum; Jood; Iode; Jod; Lugol

    119. Iodine, Resublimed Crystals, Puratronic(r)

    120. Ft-0627248

    121. Ft-0696506

    122. I0604

    123. C01382

    124. D00108

    125. Iodine, 1.0n Standardized Solution In Ethanol

    126. Iodine, Reagentplus(r), >=99.8% (titration)

    127. Q2064483

    128. Iodine, Puriss., >=99.5% (rt), Particles (round)

    129. Iodine Spheres, Ultra Dry, -10 Mesh, 99.998% Metals Basis

    130. Iodine, Anhydrous, Beads, -10 Mesh, 99.999% Trace Metals Basis

    131. Iodine, Reagentplus(r), 99.7% Trace Metals Basis, Beads, 1-3 Mm

    132. Iodide, Ion Chromatography Standard Solution, Specpure, I- 1000g/ml

    133. Iodine, 0.1n Standardized Solution In Water, Contain 1-2% Potassium Iodide

    134. Iodine Solution (0.02m In Thf/pyridine/h2o 70:20:10), For Dna Synthesis

    135. Iodine Solution (0.05m In Thf/h2o/pyridine 70:20:10), For Dna Synthesis

    136. Iodine, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, 99.8-100.5%

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 253.8089 g/mol
    Molecular Formula I2
    XLogP31.7
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count0
    Rotatable Bond Count0
    Exact Mass253.80895 g/mol
    Monoisotopic Mass253.80895 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count2
    Formal Charge0
    Complexity0
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Anti-Infective Agents, Local

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    In treatment of dendritic keratitis ... the corneas of patients have been ... exposed to air practically saturated with iodine vapor ... staining of corneal epithelium and ... loss of this layer, but complete recovery in two or three days. Tincture of iodine, swabbed on cornea, has been employed ... with same results.

    Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 519

    Chief use of solution of elemental iodine is in the disinfection of the skin. ... May also be employed in the treatment of wounds and abrasions. Applied to abraded tissue, aqueous solution are less irritating than the tincture. ... In treatment of cutaneous infections due to bacteria and fungi, usp tincture or solution ... may be employed.

    Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 965

    To treat thyrotoxic crisis or neonatal thyrotoxicosis.

    American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 805

    For more Therapeutic Uses (Complete) data for IODINE, ELEMENTAL (8 total), please visit the HSDB record page.

    4.2 Drug Warning

    In rare instances, individual may exhibit hypersensitivity to iodine and react markedly to moderate amount of the element applied to the skin. ... Iodine has a relatively low toxicity when therapeutic preparations are ingested. Few patients succumb to the effects of the drug.

    Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 965

    POTENTIAL ADVERSE EFFECTS ON FETUS: Goiters, fetal encephalopathy. POTENTIAL SIDE EFFECTS ON BREAST-FED INFANT: May cause skin rash and thyroid suppression in infant. FDA Category:D (D = There is no evidence of human fetal risk but the potential benefits from use in pregnant women may be acceptable despite the potential risks (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective.) /Iodides/ /from table II/

    Stockton, D.L. and A.S. Paller. J Am Acad Dermatol 23 (1):87-103 (1990)

    4.3 Minimum/Potential Fatal Human Dose

    Doses of 2-3 g have been fatal.

    Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1926

    4.4 Drug Indication

    Investigated for use/treatment in breast disorders (unspecified) and pain (acute or chronic).

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Infective Agents, Local

    Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

    Trace Elements

    A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Trace Elements.)

    5.2 ATC Code

    D - Dermatologicals

    D08 - Antiseptics and disinfectants

    D08A - Antiseptics and disinfectants

    D08AG - Iodine products

    D08AG03 - Iodine

    5.3 Absorption, Distribution and Excretion

    Little information is available on the gastrointestinal absorption of forms of iodine other than iodide. Iodine compounds, such as I2 and iodates (e.g., NaIO3), may undergo reduction to iodide before being absorbed in the small intestine, and absorption may not be complete.

    DHHS/ATSDR; Toxicological Profile for Iodine p. 132 (2004)

    Orally administered iodine is rapidly excreted in the urine and in smaller quantities in saliva, milk, sweat, bile, and other secretions. The storage of iodine in the thyroid depends upon the functional state of the gland.

    Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2974

    Iodine is absorbed from the lung, converted to iodide in the body, and then excreted, mainly in urine.

    International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1154

    Iodine is removed from the blood & incorporated into the organic form in the thyroid gland. Free iodine is negligible in the body.

    Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 802

    For more Absorption, Distribution and Excretion (Complete) data for IODINE, ELEMENTAL (8 total), please visit the HSDB record page.

    5.4 Metabolism/Metabolites

    Food present in the digestive tract rapidly inactivates iodine by converting it to comparatively harmless iodide.

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-213

    Inhaled methyl iodide and molecular iodine (I2) are rapidly converted to iodide. /Methyl iodide and iodine/

    DHHS/ATSDR; Toxicological Profile for Iodine p. 141 (2004)

    Ingested molecular iodine (I2) is converted to iodide.

    DHHS/ATSDR; Toxicological Profile for Iodine p. 132 (2004)

    5.5 Mechanism of Action

    Molecular iodine is known to inhibit the induction and promotion of N-methyl-n-nitrosourea-induced mammary carcinogenesis, to regress 7,12-dimethylbenz(a)anthracene-induced breast tumors in rats.It has also been shown to have beneficial effects in fibrocystic human breast disease.

    An acute iodide excess (above the preexisting dietary intake) transiently decreases the production of thyroid hormones in the thyroid gland; this is referred to as the acute Wolff-Chaikoff effect. In normal people, this is followed by a return to normal levels of hormone synthesis, referred to as escape from the acute Wolff-Chaikoff effect, without a significant change in circulating hormone levels. Escape is thought to be the result of down regulation of the sodium-iodide symport (NIS), the iodide transporter in the thyroid gland, resulting in a decrease in the intrathyroidal iodine and the resumption of normal hormone synthesis. An acute or chronic excess of iodide can also decrease circulating T4 and T3 levels and induce a hypothyroid state in some people who have underlying thyroid disorders. These effects are the result of a failure to escape from the acute Wolff-Chaikoff effect. Most people who experience iodine-induced hypothyroidism recover when the excess iodine intake is discontinued.

    DHHS/ATSDR; Toxicological Profile for Iodine p. 51 (2004)

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    ABOUT THIS PAGE

    Looking for 7553-56-2 / Iodine API manufacturers, exporters & distributors?

    Iodine manufacturers, exporters & distributors 1

    84

    PharmaCompass offers a list of Iodine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Iodine manufacturer or Iodine supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Iodine manufacturer or Iodine supplier.

    API | Excipient name

    Iodine

    Synonyms

    7553-56-2, I, Molecular iodine, Diiodine, Iodine crystals, Iodine solution

    Cas Number

    7553-56-2

    Unique Ingredient Identifier (UNII)

    9679TC07X4

    About Iodine

    A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.

    Tincture iodine Manufacturers

    A Tincture iodine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tincture iodine, including repackagers and relabelers. The FDA regulates Tincture iodine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tincture iodine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Tincture iodine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PhamaCompass.

    Tincture iodine Suppliers

    A Tincture iodine supplier is an individual or a company that provides Tincture iodine active pharmaceutical ingredient (API) or Tincture iodine finished formulations upon request. The Tincture iodine suppliers may include Tincture iodine API manufacturers, exporters, distributors and traders.

    click here to find a list of Tincture iodine suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

    Tincture iodine USDMF

    A Tincture iodine DMF (Drug Master File) is a document detailing the whole manufacturing process of Tincture iodine active pharmaceutical ingredient (API) in detail. Different forms of Tincture iodine DMFs exist exist since differing nations have different regulations, such as Tincture iodine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Tincture iodine DMF submitted to regulatory agencies in the US is known as a USDMF. Tincture iodine USDMF includes data on Tincture iodine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tincture iodine USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Tincture iodine suppliers with USDMF on PharmaCompass.

    Tincture iodine CEP

    A Tincture iodine CEP of the European Pharmacopoeia monograph is often referred to as a Tincture iodine Certificate of Suitability (COS). The purpose of a Tincture iodine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Tincture iodine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Tincture iodine to their clients by showing that a Tincture iodine CEP has been issued for it. The manufacturer submits a Tincture iodine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Tincture iodine CEP holder for the record. Additionally, the data presented in the Tincture iodine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Tincture iodine DMF.

    A Tincture iodine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Tincture iodine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Tincture iodine suppliers with CEP (COS) on PharmaCompass.

    Tincture iodine GMP

    Tincture iodine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Tincture iodine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Tincture iodine GMP manufacturer or Tincture iodine GMP API supplier for your needs.

    Tincture iodine CoA

    A Tincture iodine CoA (Certificate of Analysis) is a formal document that attests to Tincture iodine's compliance with Tincture iodine specifications and serves as a tool for batch-level quality control.

    Tincture iodine CoA mostly includes findings from lab analyses of a specific batch. For each Tincture iodine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Tincture iodine may be tested according to a variety of international standards, such as European Pharmacopoeia (Tincture iodine EP), Tincture iodine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tincture iodine USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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