Tilmicosin Phosphate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

4 API Suppliers, 4 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Formulations

6 Dossiers, 5 Canada, 1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 2 Nanjing Well Pharmaceutical, 1 Minakem, 1 BASF, 1 Finar, 1 Pharm-RX Chemical

EXCIPIENTS BY APPLICATIONS

2 Film Formers & Plasticizers, 2 API Stability Enhancers, 2 Topical, 2 Parenteral, 1 Solubilizers, 1 Fillers, Diluents & Binders, 1 Thickeners and Stabilizers

MARKET PLACE

9 APIs

9 APIs

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

EU WC

Listed Suppliers

API REF. PRICE (USD / KG)

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 137330-13-3, Tilmicosin (phosphate), Tilmicosin phosphate [usan], Ly177370 phosphate, Micotil 300, Smh7u1s683

Molecular Formula

C₄₆H₈₃N₂O₁₇P

Molecular Weight

967.1 g/mol

InChI Key

NESIVXZOSKKUDP-ARVJLQODSA-N

FDA UNII

SMH7U1S683

1 2D Structure

Tilmicosin Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione;phosphoric acid

2.1.2 InChI

InChI=1S/C46H80N2O13.H3O4P/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45;1-5(2,3)4/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3;(H3,1,2,3,4)/b15-14+,25-19+;/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-;/m1./s1

2.1.3 InChI Key

NESIVXZOSKKUDP-ARVJLQODSA-N

2.1.4 Canonical SMILES

CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)C)COC4C(C(C(C(O4)C)O)OC)OC.OP(=O)(O)O

2.1.5 Isomeric SMILES

CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3C[C@@H](C[C@@H](C3)C)C)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC.OP(=O)(O)O

2.2 Other Identifiers

2.2.1 UNII

SMH7U1S683

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin

2. El 870

3. El-870

4. Micotil 300

5. Tilmicosin

2.3.2 Depositor-Supplied Synonyms

1. 137330-13-3

2. Tilmicosin (phosphate)

3. Tilmicosin Phosphate [usan]

4. Ly177370 Phosphate

5. Micotil 300

6. Smh7u1s683

7. Tilmicosin Phosphate (usan)

8. (4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3s,5r)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione;phosphoric Acid

9. Tilmicosinphosphate

10. Pulmotil 90

11. Unii-smh7u1s683

12. Tilmicosin Phosphate, Usp

13. Schembl1184136

14. Chembl2105782

15. Hy-b0905a

16. Ly-177370 Phosphate

17. Dtxsid201019820

18. 20-deoxo-20-(3,5-dimethyl-1-piperidinyl)desmycosin Phosphate

19. Mfcd06797805

20. S5573

21. Tilmicosin Phosphate [mart.]

22. Ccg-270598

23. Cs-4729

24. Tilmicosin Phosphate [green Book]

25. 4a-o-de(2,6-dideoxy-3-c-methyl-alpha-l-ribo-hexopyranosyl)-20-deoxo-20-(cis-3,5-dimethylpiperidino)tylosin Phosphate (1:1) (salt)

26. Tylosin, 4a-o-de(2,6-dideoxy-3-c-methyl-alpha-l-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)-, (20(cis))-, Phosphate (1:1) (salt)

27. D02493

28. 330t133

29. Q-201834

30. Q27289281

31. Tilmicosin Phosphate, Antibiotic For Culture Media Use Only

32. (4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-{[(2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-7-{2-[(3r,5s)-3,5-dimethylpiperidin-1-yl]ethyl}-16-ethyl-4-hydroxy-15-({[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}methyl)-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione; Phosphoric Acid

33. 4 Sup(a)-o-de(2,6-dideoxy-3-c-methyl-.alpha.-l-ribo-hexopyranosyl)-20-deoxo-20-(cis-3,5-dimethylpiperidino)tylosin Phosphate (1:1) (salt)

34. 4(sup A)-o-de(2,6-dideoxy-3-c-methyl-alpha-l-ribo-hexopyranosyl)-20-deoxo-20-(cis-3,5-dimethylpiperidino)tylosin Phosphate (1:1) (salt)

35. Tylosin, 4 Sup(a)-o-de(2,6-dideoxy-3-c-methyl-.alpha.-l-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)-, (20(cis))-, Phosphate (1:1) (salt)

36. Tylosin, 4(sup A)-o-de(2,6-dideoxy-3-c-methyl-alpha-l-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)-, (20(cis))-, Phosphate (1:1) (salt)

2.4 Create Date

2005-10-11

3 Chemical and Physical Properties

Molecular Formula	C₄₆H₈₃N₂O₁₇P
Molecular Weight	967.1 g/mol
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	19
Rotatable Bond Count	12
Exact Mass	966.54293618 g/mol
Monoisotopic Mass	966.54293618 g/mol
Topological Polar Surface Area	264 Å²
Heavy Atom Count	66
Formal Charge	0
Complexity	1470
Isotope Atom Count	0
Defined Atom Stereocenter Count	19
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2