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Synopsis

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Chemistry

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Also known as: Tarloxotinib cation, Tarloxotinib ion, 1636938-13-0, H8768ul06v, [(e)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium, Th-4000
Molecular Formula
C24H24BrClN9O3+
Molecular Weight
601.9  g/mol
InChI Key
MUJMYVFVAWFUJL-SNAWJCMRSA-O
FDA UNII
H8768UL06V

Tarloxotinib
Tarloxotinib is under investigation in clinical trial NCT03743350 (NSCLC Exon 20 or HER2-activating Mutations).
1 2D Structure

Tarloxotinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium
2.1.2 InChI
InChI=1S/C24H23BrClN9O3/c1-33-14-30-24(34(37)38)20(33)12-35(2,3)8-4-5-22(36)32-21-10-16-19(11-27-21)28-13-29-23(16)31-15-6-7-18(26)17(25)9-15/h4-7,9-11,13-14H,8,12H2,1-3H3,(H-,27,28,29,31,32,36)/p+1/b5-4+
2.1.3 InChI Key
MUJMYVFVAWFUJL-SNAWJCMRSA-O
2.1.4 Canonical SMILES
CN1C=NC(=C1C[N+](C)(C)CC=CC(=O)NC2=NC=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)Cl)Br)[N+](=O)[O-]
2.1.5 Isomeric SMILES
CN1C=NC(=C1C[N+](C)(C)C/C=C/C(=O)NC2=NC=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)Cl)Br)[N+](=O)[O-]
2.2 Other Identifiers
2.2.1 UNII
H8768UL06V
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Tarloxotinib Cation

2. Tarloxotinib Ion

3. 1636938-13-0

4. H8768ul06v

5. [(e)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium

6. Th-4000

7. Tarloxotinib [who-dd]

8. Unii-h8768ul06v

9. Gtpl9409

10. Chembl4297661

11. Schembl19733352

12. Pr610

13. Db14944

14. Q27279755

2.4 Create Date
2011-04-25
3 Chemical and Physical Properties
Molecular Weight 601.9 g/mol
Molecular Formula C24H24BrClN9O3+
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass600.08740 g/mol
Monoisotopic Mass600.08740 g/mol
Topological Polar Surface Area143 Ų
Heavy Atom Count38
Formal Charge1
Complexity863
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1636938-13-0 / Tarloxotinib API manufacturers, exporters & distributors?

Tarloxotinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tarloxotinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tarloxotinib manufacturer or Tarloxotinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tarloxotinib manufacturer or Tarloxotinib supplier.

PharmaCompass also assists you with knowing the Tarloxotinib API Price utilized in the formulation of products. Tarloxotinib API Price is not always fixed or binding as the Tarloxotinib Price is obtained through a variety of data sources. The Tarloxotinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tarloxotinib

Synonyms

Tarloxotinib cation, Tarloxotinib ion, 1636938-13-0, H8768ul06v, [(e)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium, Th-4000

Cas Number

1636938-13-0

Unique Ingredient Identifier (UNII)

H8768UL06V

About Tarloxotinib

Tarloxotinib is under investigation in clinical trial NCT03743350 (NSCLC Exon 20 or HER2-activating Mutations).

Tarloxotinib Manufacturers

A Tarloxotinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tarloxotinib, including repackagers and relabelers. The FDA regulates Tarloxotinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tarloxotinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tarloxotinib Suppliers

A Tarloxotinib supplier is an individual or a company that provides Tarloxotinib active pharmaceutical ingredient (API) or Tarloxotinib finished formulations upon request. The Tarloxotinib suppliers may include Tarloxotinib API manufacturers, exporters, distributors and traders.

Tarloxotinib GMP

Tarloxotinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tarloxotinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tarloxotinib GMP manufacturer or Tarloxotinib GMP API supplier for your needs.

Tarloxotinib CoA

A Tarloxotinib CoA (Certificate of Analysis) is a formal document that attests to Tarloxotinib's compliance with Tarloxotinib specifications and serves as a tool for batch-level quality control.

Tarloxotinib CoA mostly includes findings from lab analyses of a specific batch. For each Tarloxotinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tarloxotinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Tarloxotinib EP), Tarloxotinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tarloxotinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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