Find Tanomastat manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 179545-77-8, Bay 12-9566, Bay-12-9566, (s)-4-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoic acid, Am1zx94exh, Bay-129566
Molecular Formula
C23H19ClO3S
Molecular Weight
410.9  g/mol
InChI Key
JXAGDPXECXQWBC-LJQANCHMSA-N
FDA UNII
AM1ZX94EXH

Tanomastat
Tanomastat is a biphenyl matrix metalloproteinase (MMP) inhibitor (MMPI) with potential antineoplastic activity. Tanomastat inhibits MMP-2, MMP-3, and MMP-9, inhibiting extracellular matrix degradation and potentially inhibiting angiogenesis, tumor growth and invasion, and metastasis. MMPs consist of at least 18 zinc-containing endo-proteinases that are capable of degrading collagen and proteoglycan.
1 2D Structure

Tanomastat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-4-[4-(4-chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic acid
2.1.2 InChI
InChI=1S/C23H19ClO3S/c24-20-12-10-17(11-13-20)16-6-8-18(9-7-16)22(25)14-19(23(26)27)15-28-21-4-2-1-3-5-21/h1-13,19H,14-15H2,(H,26,27)/t19-/m1/s1
2.1.3 InChI Key
JXAGDPXECXQWBC-LJQANCHMSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)SCC(CC(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)Cl)C(=O)O
2.1.5 Isomeric SMILES
C1=CC=C(C=C1)SC[C@@H](CC(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)Cl)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
AM1ZX94EXH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bay 12-9566

2. Bay 12-9566n

3. Bay 129566

4. Bay-12-9566

2.3.2 Depositor-Supplied Synonyms

1. 179545-77-8

2. Bay 12-9566

3. Bay-12-9566

4. (s)-4-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoic Acid

5. Am1zx94exh

6. Bay-129566

7. Chembl261932

8. (s)-4-[4-(4-chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic Acid

9. (2s)-4-[4-(4-chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic Acid

10. [1,1'-biphenyl]-4-butanoic Acid, 4'-chloro-gamma-oxo-alpha-[(phenylthio)methyl]-, (alphas)-

11. C23h19clo3s

12. Tanomastat [usan:inn]

13. Unii-am1zx94exh

14. (1,1'-biphenyl)-4-butanoic Acid, 4'-chloro-gamma-oxo-alpha-((phenylthio)methyl)-, (alphas)-

15. Tanomastat [inn]

16. Tanomastat (usan/inn)

17. Tanomastat [usan]

18. Tanomastat [who-dd]

19. Schembl153066

20. Bay12-9566

21. Gtpl6468

22. Bay 129566

23. Dtxsid60870145

24. Chebi:188765

25. Ex-a7633

26. Bay 12-9566n

27. Bdbm50084661

28. Akos015911399

29. Bay 12-9566 N

30. Db06276

31. (s)-4'-chloro-gamma-oxo-alpha-((phenylthio)methyl)(1,1'-biphenyl)-4-butanoic Acid

32. Hy-12168

33. Cs-0003131

34. Ft-0674808

35. Ns00068311

36. C90420

37. D03802

38. (1,1'-biphenyl)-4-butanoic Acid, 4'-chloro-gamma-oxo-alpha-((phenylthio)methyl)-, (s)-

39. (2s)-4-[4-(4-chlorophenyl)phenyl]-4-oxo-2-(phenylsulanylmethyl)butanoic Acid

40. (s)-3-((4'-chloro-4-biphenylyl)carbonyl)-2-((phenylthio)methyl)propionic Acid

41. (s)-4-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoicacid

42. 4-(4''-chloro-biphenyl-4-yl)-4-oxo-2-phenylsulfanylmethyl-butyric Acid(bay-12-9566)

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 410.9 g/mol
Molecular Formula C23H19ClO3S
XLogP35.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area79.7
Heavy Atom Count28
Formal Charge0
Complexity504
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in pancreatic cancer, lung cancer, ovarian cancer, and osteoarthritis.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


API SUPPLIERS

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01

Evitachem

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Simposio AFI
Not Confirmed
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Evitachem

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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02

BOC Sciences

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Simposio AFI
Not Confirmed
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BOC Sciences

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
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03

BLD Pharmatech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Simposio AFI
Not Confirmed
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BLD Pharmatech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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04

Elanco

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Simposio AFI
Not Confirmed
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Elanco

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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05

GLP Bio

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
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GLP Bio

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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06

BenchChem

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
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BenchChem

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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07

Vivan Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Vivan Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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08

Excenen PharmaTech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
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Excenen PharmaTech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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ABOUT THIS PAGE

Looking for 179545-77-8 / Tanomastat API manufacturers, exporters & distributors?

Tanomastat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tanomastat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tanomastat manufacturer or Tanomastat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tanomastat manufacturer or Tanomastat supplier.

PharmaCompass also assists you with knowing the Tanomastat API Price utilized in the formulation of products. Tanomastat API Price is not always fixed or binding as the Tanomastat Price is obtained through a variety of data sources. The Tanomastat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tanomastat

Synonyms

179545-77-8, Bay 12-9566, Bay-12-9566, (s)-4-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoic acid, Am1zx94exh, Bay-129566

Cas Number

179545-77-8

Unique Ingredient Identifier (UNII)

AM1ZX94EXH

About Tanomastat

Tanomastat is a biphenyl matrix metalloproteinase (MMP) inhibitor (MMPI) with potential antineoplastic activity. Tanomastat inhibits MMP-2, MMP-3, and MMP-9, inhibiting extracellular matrix degradation and potentially inhibiting angiogenesis, tumor growth and invasion, and metastasis. MMPs consist of at least 18 zinc-containing endo-proteinases that are capable of degrading collagen and proteoglycan.

Tanomastat Manufacturers

A Tanomastat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tanomastat, including repackagers and relabelers. The FDA regulates Tanomastat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tanomastat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tanomastat manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tanomastat Suppliers

A Tanomastat supplier is an individual or a company that provides Tanomastat active pharmaceutical ingredient (API) or Tanomastat finished formulations upon request. The Tanomastat suppliers may include Tanomastat API manufacturers, exporters, distributors and traders.

click here to find a list of Tanomastat suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tanomastat GMP

Tanomastat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tanomastat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tanomastat GMP manufacturer or Tanomastat GMP API supplier for your needs.

Tanomastat CoA

A Tanomastat CoA (Certificate of Analysis) is a formal document that attests to Tanomastat's compliance with Tanomastat specifications and serves as a tool for batch-level quality control.

Tanomastat CoA mostly includes findings from lab analyses of a specific batch. For each Tanomastat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tanomastat may be tested according to a variety of international standards, such as European Pharmacopoeia (Tanomastat EP), Tanomastat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tanomastat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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