Find Sovilnesib manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Amg-650, 2410796-79-9, Amg 650 [who-dd], Op393m4h32, Benzamide, 2-(6-azaspiro(2.5)oct-6-yl)-n-(2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl)-4-(((2-hydroxyethyl)sulfonyl)amino)-, Unii-op393m4h32
Molecular Formula
C26H34F2N6O4S
Molecular Weight
564.6  g/mol
InChI Key
KBDGEJDIHZDPHN-UHFFFAOYSA-N
FDA UNII
OP393M4H32

Sovilnesib
Sovilnesib is an orally bioavailable, small-molecule inhibitor of the human kinesin-like protein KIF18A, with potential antineoplastic activity. Upon oral administration, sovilnesib selectively inhibits the activity of KIF18A. This may result in multipolar cell division and inhibit tumor cell proliferation. KIF18A, a mitotic kinesin-8 motor protein, plays an important role in the regulation of chromosome positioning during cell division and is overexpressed in certain cancers. Certain cancer cells with chromosomal instability (CIN) features depend on KIF18A activity for bipolar spindle integrity and cell proliferation.
1 2D Structure

Sovilnesib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-(2-hydroxyethylsulfonylamino)benzamide
2.1.2 InChI
InChI=1S/C26H34F2N6O4S/c1-18-16-22(31-24(29-18)34-12-8-26(27,28)9-13-34)30-23(36)20-3-2-19(32-39(37,38)15-14-35)17-21(20)33-10-6-25(4-5-25)7-11-33/h2-3,16-17,32,35H,4-15H2,1H3,(H,29,30,31,36)
2.1.3 InChI Key
KBDGEJDIHZDPHN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=NC(=N1)N2CCC(CC2)(F)F)NC(=O)C3=C(C=C(C=C3)NS(=O)(=O)CCO)N4CCC5(CC5)CC4
2.2 Other Identifiers
2.2.1 UNII
OP393M4H32
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Amg-650

2. 2410796-79-9

3. Amg 650 [who-dd]

4. Op393m4h32

5. Benzamide, 2-(6-azaspiro(2.5)oct-6-yl)-n-(2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl)-4-(((2-hydroxyethyl)sulfonyl)amino)-

6. Unii-op393m4h32

7. Chembl5084301

8. Schembl22119383

9. Us11236069, Example 4

10. Bdbm535532

11. Ex-a6760

12. Us11236069, Example 15

13. Nsc839866

14. Nsc-839866

15. Hy-132840

16. Cs-0204143

17. 2-(6-azaspiro[2.5]octan-6-yl)-n-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-(2-hydroxyethylsulfonylamino)benzamide

18. N-(2-(4,4-difluoropiperidin-1-yl)-6- Methylpyrimidin-4-yl)-4-((2- Hydroxyethyl)sulfonamido)-2-(6- Azaspiro[2.5]octan-6-yl)benzamide

2.4 Create Date
2020-08-12
3 Chemical and Physical Properties
Molecular Weight 564.6 g/mol
Molecular Formula C26H34F2N6O4S
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count8
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area136
Heavy Atom Count39
Formal Charge0
Complexity958
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 2410796-79-9 / Sovilnesib API manufacturers, exporters & distributors?

Sovilnesib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sovilnesib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sovilnesib manufacturer or Sovilnesib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sovilnesib manufacturer or Sovilnesib supplier.

PharmaCompass also assists you with knowing the Sovilnesib API Price utilized in the formulation of products. Sovilnesib API Price is not always fixed or binding as the Sovilnesib Price is obtained through a variety of data sources. The Sovilnesib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sovilnesib

Synonyms

Amg-650, 2410796-79-9, Amg 650 [who-dd], Op393m4h32, Benzamide, 2-(6-azaspiro(2.5)oct-6-yl)-n-(2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl)-4-(((2-hydroxyethyl)sulfonyl)amino)-, Unii-op393m4h32

Cas Number

2410796-79-9

Unique Ingredient Identifier (UNII)

OP393M4H32

About Sovilnesib

Sovilnesib is an orally bioavailable, small-molecule inhibitor of the human kinesin-like protein KIF18A, with potential antineoplastic activity. Upon oral administration, sovilnesib selectively inhibits the activity of KIF18A. This may result in multipolar cell division and inhibit tumor cell proliferation. KIF18A, a mitotic kinesin-8 motor protein, plays an important role in the regulation of chromosome positioning during cell division and is overexpressed in certain cancers. Certain cancer cells with chromosomal instability (CIN) features depend on KIF18A activity for bipolar spindle integrity and cell proliferation.

Sovilnesib Manufacturers

A Sovilnesib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sovilnesib, including repackagers and relabelers. The FDA regulates Sovilnesib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sovilnesib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sovilnesib Suppliers

A Sovilnesib supplier is an individual or a company that provides Sovilnesib active pharmaceutical ingredient (API) or Sovilnesib finished formulations upon request. The Sovilnesib suppliers may include Sovilnesib API manufacturers, exporters, distributors and traders.

Sovilnesib GMP

Sovilnesib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sovilnesib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sovilnesib GMP manufacturer or Sovilnesib GMP API supplier for your needs.

Sovilnesib CoA

A Sovilnesib CoA (Certificate of Analysis) is a formal document that attests to Sovilnesib's compliance with Sovilnesib specifications and serves as a tool for batch-level quality control.

Sovilnesib CoA mostly includes findings from lab analyses of a specific batch. For each Sovilnesib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sovilnesib may be tested according to a variety of international standards, such as European Pharmacopoeia (Sovilnesib EP), Sovilnesib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sovilnesib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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