Sodium Sulfite

Synopsis, Chemistry

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Also known as: 7757-83-7, Sodium sulphite, Sodium sulfite anhydrous, Disodium sulfite, Sulfurous acid, disodium salt, Natrium sulfurosum

Molecular Formula

Na₂O₃S

Molecular Weight

126.05 g/mol

InChI Key

GEHJYWRUCIMESM-UHFFFAOYSA-L

FDA UNII

VTK01UQK3G

Sodium Sulfite is a white crystal or powder with reducing property. Sodium sulfite exhibits bleaching, de-sulfurizing, and dechlorinating activities. This agent was used by food industry to help maintain the fresh appearance of food products. It is also a component in many drugs, which helps maintain their potency and stability. FDA has ruled sodium sulfite a new animal drug of low regulatory priority.

1 2D Structure

Sodium Sulfite

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;sulfite

2.1.2 InChI

InChI=1S/2Na.H2O3S/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2

2.1.3 InChI Key

GEHJYWRUCIMESM-UHFFFAOYSA-L

2.1.4 Canonical SMILES

[O-]S(=O)[O-].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

VTK01UQK3G

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Sodium Sulfite, 35s-labeled Cpd

2. Sodium Sulfite, Heptahydrate

3. Sodium Sulphite

4. Sulfurous Acid, Sodium Salt

2.3.2 Depositor-Supplied Synonyms

1. 7757-83-7

2. Sodium Sulphite

3. Sodium Sulfite Anhydrous

4. Disodium Sulfite

5. Sulfurous Acid, Disodium Salt

6. Natrium Sulfurosum

7. S-wat

8. Natriumsulfid

9. Natriumsulfit

10. Anhydrous Sodium Sulfite

11. Sodium Sulfite (na2so3)

12. Sulfurous Acid, Sodium Salt

13. Sodium Sulfite, Anhydrous

14. Natrum Sulphurosum

15. Sulfurous Acid, Sodium Salt (1:2)

16. Dried Sodium Sulfite

17. Sodium Sulfite [nf]

18. Anhydrous Sodium Sulphite

19. Na2so3

20. Sodium Sulphite Anhydrous

21. Mfcd00003503

22. Vtk01uqk3g

23. Ins No.221

24. Sulftech

25. Chebi:86477

26. Ins-221

27. Sodium Sulfite (nf)

28. Sodiumsulfite

29. Natrii Sulphis

30. Natriumsulfid [german]

31. Natriumsulfit [german]

32. Exsiccated Sodium Sulfite

33. Sodium Sulfite, Exsiccated

34. Disodium Sulfite (na2so3)

35. Ccris 1429

36. Hsdb 5043

37. Sodium Sulfite Solution

38. Sodium Sulfite (2:1)

39. Einecs 231-821-4

40. Unii-vtk01uqk3g

41. Sodium-sulfite

42. Ec 231-821-4

43. Sodium Sulfite [ii]

44. Sodium Sulfite [mi]

45. Sodium Sulfite [fcc]

46. Sodium Sulfite [hsdb]

47. Sodium Sulfite [inci]

48. Dried Sodium Sulfite (jp17)

49. Sodium Sulfite [vandf]

50. Sodium Sulfite [mart.]

51. Chembl1945334

52. Dtxsid2044260

53. Sodium Sulfite Acs Reagent Grade

54. Natrum Sulphurosum [hpus]

55. Dried Sodium Sulfite [jp]

56. Dried Sodium Sulfite [jan]

57. Sodium Sulfite [ep Monograph]

58. Sodium Sulfite Anhydrous, Photo Grade

59. Akos028109676

60. Bp-21395

61. Ft-0645146

62. D09002

63. Sodium Sulfite, Anhydrous [ep Impurity]

64. Q407806

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	Na₂O₃S
Molecular Weight	126.05 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	125.93635360 g/mol
Monoisotopic Mass	125.93635360 g/mol
Topological Polar Surface Area	82.4 Å²
Heavy Atom Count	6
Formal Charge	0
Complexity	18.8
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Therapeutic Uses

Vet: antioxidant, antiseptic

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 547

4.2 Minimum/Potential Fatal Human Dose

See sulfite salts. 3. 3= Moderately toxic: probable oral lethal dose (human) 0.5-5 g/kg, between 1 oz and 1 pint (or 1 lb) for 70 kg person (150 lb). /Sulfite salts/

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-123

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

Skin penetration would be low due to the highly charged nature of these particles and any sulfite that did penetrate would be converted to sulfate by the enzyme sulfate oxidase.

PMID:14555420 Nair B, Elmore AR; Int J Toxicol 22 (Suppl 2) :63-88 (2003)

5.2 Metabolism/Metabolites

Sulfites that enter mammals via ingestion, inhalation, or injection are metabolized by sulfite oxidase to sulfate.

PMID:14555420 Nair B, Elmore AR; Int J Toxicol 22 (Suppl 2) :63-88 (2003)