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SODIUM CHLORITE

SODIUM CHLORITE

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Also known as: 7758-19-2, Chlorous acid, sodium salt, Textone, Sodium;chlorite, Chlorite sodium, Naclo2

Molecular Formula

ClNaO₂

Molecular Weight

90.44 g/mol

InChI Key

UKLNMMHNWFDKNT-UHFFFAOYSA-M

FDA UNII

G538EBV4VF

Used as an agent for cleaning drinking water. It is also used as an additive in products like toothpaste and mouthwash. Acidified sodium chlorite was approved by the U.S. Food and Drug Administration as of 2004, as an anti-microbial agent which is non-toxic, but not as a drug.

1 2D Structure

SODIUM CHLORITE

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;chlorite

2.1.2 InChI

InChI=1S/ClHO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1

2.1.3 InChI Key

UKLNMMHNWFDKNT-UHFFFAOYSA-M

2.1.4 Canonical SMILES

[O-]Cl=O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

G538EBV4VF

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Chlorite

2.3.2 Depositor-Supplied Synonyms

1. 7758-19-2

2. Chlorous Acid, Sodium Salt

3. Textone

4. Sodium;chlorite

5. Chlorite Sodium

6. Naclo2

7. G538ebv4vf

8. Chebi:78667

9. Sodium Chlorite (water Disinfection Byproducts)

10. Textile

11. Alcide Ld

12. Neo Silox D

13. Caswell No. 755

14. Sodiumchlorite

15. Ccris 1426

16. Hsdb 733

17. Chlorite (sodium Salt)

18. Einecs 231-836-6

19. Un1496

20. Unii-g538ebv4vf

21. Epa Pesticide Chemical Code 020502

22. Chlorous Acid, Sodium Salt (1:1)

23. Nao2cl

24. Dsstox_cid_1272

25. Ec 231-836-6

26. Dsstox_rid_76050

27. Dsstox_gsid_21272

28. Sodium Chlorite [mi]

29. Sodium Chlorite [hsdb]

30. Sodium Chlorite [iarc]

31. Sodium Chlorite [inci]

32. Chembl1887585

33. Dtxsid8021272

34. Sodium Chlorite [who-dd]

35. Tox21_302800

36. Mfcd00003478

37. Akos015843819

38. Db13210

39. Ncgc00091419-01

40. Ncgc00256359-01

41. Sodium Chlorite [un1496] [oxidizer]

42. Cas-7758-19-2

43. Ft-0695293

44. C19523

45. Q411294

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	ClNaO₂
Molecular Weight	90.44 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	89.9484512 g/mol
Monoisotopic Mass	89.9484512 g/mol
Topological Polar Surface Area	40.1 Å²
Heavy Atom Count	4
Formal Charge	0
Complexity	13.5
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Therapeutic Uses

/VET/ Sodium chlorite is used in veterinary medicine as a medical disinfectant in post-milking teat dip products used topically for the control of mastitis in dairy cattle.

European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products; Sodium Chlorite, Summary Report. Available from, as of July 29, 2008: https://www.emea.europa.eu/pdfs/vet/mrls/sodiumchlorite.pdf

5 Pharmacology and Biochemistry

5.1 ATC Code

D - Dermatologicals

D03 - Preparations for treatment of wounds and ulcers

D03A - Cicatrizants

D03AX - Other cicatrizants

D03AX11 - Sodium chlorite

5.2 Absorption, Distribution and Excretion

... The dermal absorption /was reported on/ Alcide, an antimicrobial compound consisting of solutions of sodium chlorite and lactic acid, which when mixed immediately before use result in the formation of chlorine dioxide. 0.6 g (36)Cl-labeled sodium chlorite as part of the Alcide was used to monitor absorption following application to the shaved backs of 10 female Sprague-Dawley rats. Maximum absorption of (36)Cl into plasma was observed after 72 hours, where a plasma concentration of 69.4 ug% (36)Cl was reached. The absorption half-life was calculated to be 22.1 hours, which corresponds to a rate constant of 0.0314 hr-1. /Alcide/

USEPA; TOXICOLOGICAL REVIEW OF CHLORINE DIOXIDE AND CHLORITE (CAS Nos. 10049-04-4 and 7758-19-2) In Support of Summary Information on the Integrated Risk Information System (IRIS) p.4 (September 2000) EPA/635/R-00/007. Available from, as of July 31, 2008: https://cfpub.epa.gov/ncea/iris/index.cfm?fuseaction=iris.showSubstanceList

... Sodium chlorite /was/ shown to be well absorbed by the oral route in rats, by using radiolabelled compound (Cmax 1-2 hours). ... The main route of excretion ... appeared to be via the kidneys, predominantly as chloride (32% of the dose at 72 hours), with some chloride (32% of the dose at 72 hours) and a little chlorate (0.73% of the dose at 72 hours). ... 83% of the recovered dose was found in urine, and 13% in feces. ...