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Chemistry

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Also known as: 908115-27-5, Pf-04929113, Snx 5422, Pf-4929113, Pf 04929113, Snx5422
Molecular Formula
C25H30F3N5O4
Molecular Weight
521.5  g/mol
InChI Key
AVDSOVJPJZVBTC-UHFFFAOYSA-N
FDA UNII
BF52J69Q8T

Snx-5422
SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.
1 2D Structure

Snx-5422

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-[2-carbamoyl-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]anilino]cyclohexyl] 2-aminoacetate
2.1.2 InChI
InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)
2.1.3 InChI Key
AVDSOVJPJZVBTC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C
2.2 Other Identifiers
2.2.1 UNII
BF52J69Q8T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Glycine Trans-4-((2-(aminocarbonyl)-5-(4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1h-indazol-1-yl)phenyl)amino)cyclohexyl Ester

2. Pf 04929113

3. Pf-04929113

4. Pf-4929113

5. Pf04929113

6. Snx-5422 Mesylate

2.3.2 Depositor-Supplied Synonyms

1. 908115-27-5

2. Pf-04929113

3. Snx 5422

4. Pf-4929113

5. Pf 04929113

6. Snx5422

7. Pf04929113

8. Pf-04929113 (snx-5422)

9. Pf-04929113 Free Base

10. Bf52j69q8t

11. 908115-27-5 (free Base)

12. (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1h-indazol-1-yl)phenyl)amino)cyclohexyl Glycinate

13. [4-[2-carbamoyl-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]anilino]cyclohexyl] 2-aminoacetate

14. Glycine, Trans-4-((2-(aminocarbonyl)-5-(4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1h-indazol-1-yl)phenyl)amino)cyclohexyl Ester

15. 908116-67-6

16. Glycine, 4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1h-indazol-1-yl]phenyl]amino]cyclohexyl Ester

17. Unii-bf52j69q8t

18. Mls006011083

19. Schembl1220790

20. Schembl1220791

21. Chembl1195136

22. Schembl15604989

23. Dtxsid50238270

24. Snx 5422 [who-dd]

25. Bcpp000065

26. Hms3656b09

27. Bcp02427

28. Ex-a2343

29. Bdbm50514916

30. Nsc768509

31. S2656

32. Zinc95616595

33. Akos027276395

34. Zinc100071931

35. Zinc252517142

36. Ccg-269865

37. Cs-0272

38. Db06070

39. Nsc-768509

40. Sb16643

41. Ncgc00346640-01

42. Ncgc00346640-04

43. Ncgc00386184-02

44. Ac-36033

45. Hy-10213

46. Smr004702871

47. Sw220153-1

48. Snx-5422(pf04929113)

49. Pf-0492911 - Snx-5422

50. Pf-04929113; Snx-5422

51. A857805

52. J-521414

53. Brd-k73197500-066-01-7

54. Q27274626

55. (1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate

56. Glycine Trans-4-((2-(aminocarbonyl)-5-(4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1h-indazol-1-yl)phenyl)amino)cycloh Exyl Ester

57. Glycine Trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1h-indazol-1-yl]phenyl]amino]cyclohexyl Ester;pf-04929113

58. Trans-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1h-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate

2.4 Create Date
2009-09-16
3 Chemical and Physical Properties
Molecular Weight 521.5 g/mol
Molecular Formula C25H30F3N5O4
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass521.22498894 g/mol
Monoisotopic Mass521.22498894 g/mol
Topological Polar Surface Area142 Ų
Heavy Atom Count37
Formal Charge0
Complexity877
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in cancer/tumors (unspecified).


5 Pharmacology and Biochemistry
5.1 Pharmacology

SNX-5422 is under development by Serenex. It is orally administered (pill form). Once in the body, SNX-5422 is converted to SNX-2122; that is, SNX-5422 is a prodrug of SNX-2112, which is the active form.


5.2 Mechanism of Action

SNX-5422 is a direct, potent inhibitor of Hsp90 across a broad range of human cancer cell lines and causes degradation of important Hsp90 client proteins including HER2, AKT and ERK.


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Snx-5422 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Snx-5422 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Snx-5422 manufacturer or Snx-5422 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Snx-5422 manufacturer or Snx-5422 supplier.

PharmaCompass also assists you with knowing the Snx-5422 API Price utilized in the formulation of products. Snx-5422 API Price is not always fixed or binding as the Snx-5422 Price is obtained through a variety of data sources. The Snx-5422 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Snx-5422

Synonyms

908115-27-5, Pf-04929113, Snx 5422, Pf-4929113, Pf 04929113, Snx5422

Cas Number

908115-27-5

Unique Ingredient Identifier (UNII)

BF52J69Q8T

About Snx-5422

SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.

SNX-5422(PF04929113) Manufacturers

A SNX-5422(PF04929113) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of SNX-5422(PF04929113), including repackagers and relabelers. The FDA regulates SNX-5422(PF04929113) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. SNX-5422(PF04929113) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

SNX-5422(PF04929113) Suppliers

A SNX-5422(PF04929113) supplier is an individual or a company that provides SNX-5422(PF04929113) active pharmaceutical ingredient (API) or SNX-5422(PF04929113) finished formulations upon request. The SNX-5422(PF04929113) suppliers may include SNX-5422(PF04929113) API manufacturers, exporters, distributors and traders.

SNX-5422(PF04929113) GMP

SNX-5422(PF04929113) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of SNX-5422(PF04929113) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right SNX-5422(PF04929113) GMP manufacturer or SNX-5422(PF04929113) GMP API supplier for your needs.

SNX-5422(PF04929113) CoA

A SNX-5422(PF04929113) CoA (Certificate of Analysis) is a formal document that attests to SNX-5422(PF04929113)'s compliance with SNX-5422(PF04929113) specifications and serves as a tool for batch-level quality control.

SNX-5422(PF04929113) CoA mostly includes findings from lab analyses of a specific batch. For each SNX-5422(PF04929113) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

SNX-5422(PF04929113) may be tested according to a variety of international standards, such as European Pharmacopoeia (SNX-5422(PF04929113) EP), SNX-5422(PF04929113) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (SNX-5422(PF04929113) USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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