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Chemistry

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Also known as: 22199-08-2, Sulfadiazine silver, Flamazine, Sulfadiazine silver salt, Silvadene, Dermazin
Molecular Formula
C10H9AgN4O2S
Molecular Weight
357.14  g/mol
InChI Key
UEJSSZHHYBHCEL-UHFFFAOYSA-N
FDA UNII
W46JY43EJR

Silver Sulfadiazine
Antibacterial used topically in burn therapy.
Silver sulfadiazine is a Sulfonamide Antibacterial.
1 2D Structure

Silver Sulfadiazine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
2.1.2 InChI
InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
2.1.3 InChI Key
UEJSSZHHYBHCEL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
2.2 Other Identifiers
2.2.1 UNII
W46JY43EJR
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Brandiazin

2. Dermazin

3. Flamazine

4. Flammazine

5. Sicazine

6. Silvadene

7. Silvederma

8. Silver Sulfafdiazine

9. Ssd

10. Ssd Af

11. Sulfadiazine, Silver

12. Sulfafdiazine, Silver

13. Sulfargen

14. Thermazene

2.3.2 Depositor-Supplied Synonyms

1. 22199-08-2

2. Sulfadiazine Silver

3. Flamazine

4. Sulfadiazine Silver Salt

5. Silvadene

6. Dermazin

7. Silver Sulphadiazine

8. Thermazene

9. Sulfadiazine, Silver

10. Dermazine

11. Geben

12. Silver Sulfadiazinate

13. Silvazine

14. Altreet-ag

15. Mfcd00072101

16. Ssd

17. W46jy43ejr

18. Chebi:9142

19. Benzenesulfonamide, 4-amino-n-2-pyrimidinyl-, Monosilver(1+) Salt

20. Silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide

21. N(sup 1)-2-pyrimidinylsulfanilamide Monosilver(1+) Salt

22. Silbertone

23. Silver(i) Sulfadiazine

24. Sulfadiazin Silber

25. Dsstox_cid_28572

26. Dsstox_rid_82844

27. Dsstox_gsid_48646

28. Sulfadiazin, Silbersalz

29. Silvadene (tn)

30. Silver(1+) [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide

31. Sulfadiazine, Silver [usan]

32. Cas-22199-08-2

33. Nsc625324

34. Ncgc00183137-01

35. Ncgc00188438-01

36. Unii-w46jy43ejr

37. N1-2-pyrimidinylsulfanilamide Monosilver(1+) Salt

38. Sulfadiazine, Silver (usp)

39. 4-amino-n-(2-pyrimidinyl)benzenesulfonamide Silver Salt

40. Sulfadiazine, Silver [usan:usp]

41. Einecs 244-834-5

42. Sulfadiazinum Argentum

43. Nsc 625324

44. (4-amino-n-pyrimidin-2-ylbenzenesulphonamidato-nn,o1)silver

45. Silver Sulfadiazine Usp

46. Silver, (4-amino-n-(2-pyrimidinyl-.kappa.n1)benzenesulfonamidato-.kappa.o)-

47. Silver, (4-amino-n-2-pyrimidinylbenzenesulfonamidato-nn,o1)-

48. Silver (i) Sulfadiazine

49. Schembl15633

50. Sulfadiazine Silver (jp17)

51. Silver Sulfadiazine Bulk Powder

52. Chembl1382627

53. Dtxsid4048646

54. Sulfadiazine Silver [jan]

55. (4-amino-n-2-pyrimidinylbenzenesulfonamidato-nn,01)-silver

56. Sulfanilamide, N(sup 1)-2-pyrimidinyl-, Monosilver(1+) Salt

57. Silver Sulfadiazine [vandf]

58. Sulfadiazine Silver [mart.]

59. Tox21_112998

60. Tox21_113471

61. Silver Sulfadiazine [usp-rs]

62. Sulfadiazine Silver [who-dd]

63. Sulfadiazine Silver [who-ip]

64. Sulfadiazine Silver Salt [mi]

65. Akos005111099

66. Ac-3535

67. Db05245

68. Silver Sulfadiazine [green Book]

69. Silver Sulfadiazine [orange Book]

70. As-13863

71. Sy105573

72. Silver Sulfadiazine [usp Monograph]

73. Db-045839

74. Sulfadiazine, Silver [usp Impurity]

75. Ft-0630481

76. S0595

77. Sulfadiazinum Argentum [who-ip Latin]

78. D00433

79. Q420984

80. J-014582

81. Silver (4-aminophenyl)sulfonyl-pyrimidin-2-yl-azanide

82. [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide (ag+)

83. 4-amino-n-(2-pyrimidinyl) Benzenesulfonamide Silver Salt

84. Silver(i) ((4-aminophenyl)sulfonyl)(pyrimidin-2-yl)amide

85. Silver(1+) Ion 4-{[(pyrimidin-2-yl)azanidyl]sulfonyl}aniline

86. Benzenesulfonamide, 4-amino-n-2-pyrimidinyl-, Silver(1+) Salt (1:1)

87. 1152234-18-8

2.3.3 Other Synonyms

1. Soludiazine

2. Suthogen

3. Sulfadiazin-natrium

4. Sulfadiazine Silver

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 357.14 g/mol
Molecular Formula C10H9AgN4O2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass355.94971 g/mol
Monoisotopic Mass355.94971 g/mol
Topological Polar Surface Area95.3 Ų
Heavy Atom Count18
Formal Charge0
Complexity327
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 8  
Drug NameSilvadene
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyKing Pharms

2 of 8  
Drug NameSsd
PubMed HealthSilver Sulfadiazine (On the skin)
Drug ClassesAntibacterial
Drug LabelSILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of SILVADENE Cream 1% contains 10 mg of micronized silver sulfa...
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyDr Reddys La

3 of 8  
Drug NameSsd af
PubMed HealthSilver Sulfadiazine (On the skin)
Drug ClassesAntibacterial
Drug LabelSSD (1% Silver Sulfadiazine Cream) and SSD AF (1% Silver Sulfadiazine Cream), 1% are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine. The active moiety is contained within an opaque, wh...
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyDr Reddys La

4 of 8  
Drug NameThermazene
PubMed HealthSilver Sulfadiazine (On the skin)
Drug ClassesAntibacterial
Drug LabelThermazene (silver sulfadiazine Cream, 1% is a soft, water dispersible cream containing silver sulfadiazine in micronized form for topical application. Each gram of Thermazene contains 10mg of micronized silver sulfadiazine. Thermazene contains 1...
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyThepharmanetwork

5 of 8  
Drug NameSilvadene
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyKing Pharms

6 of 8  
Drug NameSsd
PubMed HealthSilver Sulfadiazine (On the skin)
Drug ClassesAntibacterial
Drug LabelSILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of SILVADENE Cream 1% contains 10 mg of micronized silver sulfa...
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyDr Reddys La

7 of 8  
Drug NameSsd af
PubMed HealthSilver Sulfadiazine (On the skin)
Drug ClassesAntibacterial
Drug LabelSSD (1% Silver Sulfadiazine Cream) and SSD AF (1% Silver Sulfadiazine Cream), 1% are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine. The active moiety is contained within an opaque, wh...
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyDr Reddys La

8 of 8  
Drug NameThermazene
PubMed HealthSilver Sulfadiazine (On the skin)
Drug ClassesAntibacterial
Drug LabelThermazene (silver sulfadiazine Cream, 1% is a soft, water dispersible cream containing silver sulfadiazine in micronized form for topical application. Each gram of Thermazene contains 10mg of micronized silver sulfadiazine. Thermazene contains 1...
Active IngredientSilver sulfadiazine
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyThepharmanetwork

4.2 Drug Indication

Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.


5.2 MeSH Pharmacological Classification

Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
SILVER SULFADIAZINE
5.3.2 FDA UNII
W46JY43EJR
5.3.3 Pharmacological Classes
Sulfonamides [CS]; Sulfonamide Antibacterial [EPC]
5.4 ATC Code

D06BA01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06B - Chemotherapeutics for topical use

D06BA - Sulfonamides

D06BA01 - Silver sulfadiazine


5.5 Absorption, Distribution and Excretion

Absorption

Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.


5.6 Mechanism of Action

Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.


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04-Mar-2022
17-Jul-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CREAM;TOPICAL - 1%

USFDA APPLICATION NUMBER - 17381

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DOSAGE - CREAM;TOPICAL - 1%

USFDA APPLICATION NUMBER - 18578

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ABOUT THIS PAGE

Looking for 1152234-18-8 / Silver Sulfadiazine API manufacturers, exporters & distributors?

Silver Sulfadiazine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Silver Sulfadiazine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Silver Sulfadiazine manufacturer or Silver Sulfadiazine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Silver Sulfadiazine manufacturer or Silver Sulfadiazine supplier.

PharmaCompass also assists you with knowing the Silver Sulfadiazine API Price utilized in the formulation of products. Silver Sulfadiazine API Price is not always fixed or binding as the Silver Sulfadiazine Price is obtained through a variety of data sources. The Silver Sulfadiazine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Silver Sulfadiazine

Synonyms

22199-08-2, Sulfadiazine silver, Flamazine, Sulfadiazine silver salt, Silvadene, Dermazin

Cas Number

1152234-18-8

Unique Ingredient Identifier (UNII)

W46JY43EJR

About Silver Sulfadiazine

Antibacterial used topically in burn therapy.

Silver Sulfadiazine Manufacturers

A Silver Sulfadiazine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Silver Sulfadiazine, including repackagers and relabelers. The FDA regulates Silver Sulfadiazine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Silver Sulfadiazine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Silver Sulfadiazine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Silver Sulfadiazine Suppliers

A Silver Sulfadiazine supplier is an individual or a company that provides Silver Sulfadiazine active pharmaceutical ingredient (API) or Silver Sulfadiazine finished formulations upon request. The Silver Sulfadiazine suppliers may include Silver Sulfadiazine API manufacturers, exporters, distributors and traders.

click here to find a list of Silver Sulfadiazine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Silver Sulfadiazine USDMF

A Silver Sulfadiazine DMF (Drug Master File) is a document detailing the whole manufacturing process of Silver Sulfadiazine active pharmaceutical ingredient (API) in detail. Different forms of Silver Sulfadiazine DMFs exist exist since differing nations have different regulations, such as Silver Sulfadiazine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Silver Sulfadiazine DMF submitted to regulatory agencies in the US is known as a USDMF. Silver Sulfadiazine USDMF includes data on Silver Sulfadiazine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Silver Sulfadiazine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Silver Sulfadiazine suppliers with USDMF on PharmaCompass.

Silver Sulfadiazine JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Silver Sulfadiazine Drug Master File in Japan (Silver Sulfadiazine JDMF) empowers Silver Sulfadiazine API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Silver Sulfadiazine JDMF during the approval evaluation for pharmaceutical products. At the time of Silver Sulfadiazine JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Silver Sulfadiazine suppliers with JDMF on PharmaCompass.

Silver Sulfadiazine WC

A Silver Sulfadiazine written confirmation (Silver Sulfadiazine WC) is an official document issued by a regulatory agency to a Silver Sulfadiazine manufacturer, verifying that the manufacturing facility of a Silver Sulfadiazine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Silver Sulfadiazine APIs or Silver Sulfadiazine finished pharmaceutical products to another nation, regulatory agencies frequently require a Silver Sulfadiazine WC (written confirmation) as part of the regulatory process.

click here to find a list of Silver Sulfadiazine suppliers with Written Confirmation (WC) on PharmaCompass.

Silver Sulfadiazine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Silver Sulfadiazine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Silver Sulfadiazine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Silver Sulfadiazine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Silver Sulfadiazine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Silver Sulfadiazine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Silver Sulfadiazine suppliers with NDC on PharmaCompass.

Silver Sulfadiazine GMP

Silver Sulfadiazine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Silver Sulfadiazine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Silver Sulfadiazine GMP manufacturer or Silver Sulfadiazine GMP API supplier for your needs.

Silver Sulfadiazine CoA

A Silver Sulfadiazine CoA (Certificate of Analysis) is a formal document that attests to Silver Sulfadiazine's compliance with Silver Sulfadiazine specifications and serves as a tool for batch-level quality control.

Silver Sulfadiazine CoA mostly includes findings from lab analyses of a specific batch. For each Silver Sulfadiazine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Silver Sulfadiazine may be tested according to a variety of international standards, such as European Pharmacopoeia (Silver Sulfadiazine EP), Silver Sulfadiazine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Silver Sulfadiazine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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