Silatecan

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

1 API Suppliers, 1 Listed Suppliers

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Avra Laboratories

Avra Laboratories - Custom Synthesis from Idea to Market.

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India

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Silatecan

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- About The Company

Avra Laboratories, part of Cohance Lifesciences, is one of the first companies in India to provide high-end contract research and manufacturing of advanced intermediates and APIs, with expertise in oncology ADC payloads and o...
Avra Laboratories, part of Cohance Lifesciences, is one of the first companies in India to provide high-end contract research and manufacturing of advanced intermediates and APIs, with expertise in oncology ADC payloads and other therapeutic areas. Avra Lab is the pioneer in the synthetic camptothecin chemistry, offering its APIs, ADC payloads and intermediates. Avra Lab is renowned for its custom synthesis services, particularly in the synthesis of complex chemicals for pharmaceutical applications. It excels in low-volume, high-value small molecule synthesis. Avra lab is also a leader in carbonylation and palladium cross-coupling chemistry.

INS 2024

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Looking for 220913-32-6 / Silatecan API manufacturers, exporters & distributors?

PharmaCompass offers a list of Silatecan API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Silatecan manufacturer or Silatecan supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Silatecan manufacturer or Silatecan supplier.

PharmaCompass also assists you with knowing the Silatecan API Price utilized in the formulation of products. Silatecan API Price is not always fixed or binding as the Silatecan Price is obtained through a variety of data sources. The Silatecan Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Silatecan

Synonyms

Ar-67, 220913-32-6, Db-67, Ar67, Db 67; silatecan, Db 67

Cas Number

220913-32-6

Unique Ingredient Identifier (UNII)

3YEA04NV6H

About Silatecan

Silatecan AR-67 is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. 7-tert-butyldimethylsilyl-10-hydroxycamptothecin binds to and stabilizes the topoisomerase I-DNA covalent complex. This inhibits the religation of topoisomerase I-mediated single-stranded DNA breaks and produces lethal double-stranded DNA breaks when encountered by the DNA replication machinery, thereby inhibiting DNA replication and inducing apoptosis. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form. Modifications on the E ring of camptothecin prevent binding of human serum albumin, which prefers the inactive carboxylate form, thereby enhancing the stability of the active lactone structure and resulting in prolonged agent activity. In addition, this agent sensitizes tumor cells toward radiation treatment.

Silatecan Manufacturers

A Silatecan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Silatecan, including repackagers and relabelers. The FDA regulates Silatecan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Silatecan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Silatecan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Silatecan Suppliers

A Silatecan supplier is an individual or a company that provides Silatecan active pharmaceutical ingredient (API) or Silatecan finished formulations upon request. The Silatecan suppliers may include Silatecan API manufacturers, exporters, distributors and traders.

click here to find a list of Silatecan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Silatecan Manufacturers | Traders | Suppliers

We have 1 companies offering Silatecan

Get in contact with the supplier of your choice:

Avra Laboratories

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.