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Chemistry

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Also known as: 57262-94-9, Org-8282, Setiptiline [inn], Org 8282, Mo 8282, 2,3,4,9-tetrahydro-2-methyl-1h-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
Molecular Formula
C19H19N
Molecular Weight
261.4  g/mol
InChI Key
GVPIXRLYKVFFMK-UHFFFAOYSA-N
FDA UNII
7L38105Z6E

Setiptiline
Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). In Japan, the company Mochida started its commercialization for the treatment of depression started in 1989.
1 2D Structure

Setiptiline

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-methyl-4-azatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene
2.1.2 InChI
InChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3
2.1.3 InChI Key
GVPIXRLYKVFFMK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCC2=C(C1)C3=CC=CC=C3CC4=CC=CC=C24
2.2 Other Identifiers
2.2.1 UNII
7L38105Z6E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,2,3,4-tetrahydro-2-methyl-9h-dibenzo(3,4-6,7)cyclohepta(1,2-c)pyridine

2. 13b,4a-carba-mianserin

3. Mo 8282

4. Mo-8282

5. Org 8282

6. Org-8282

2.3.2 Depositor-Supplied Synonyms

1. 57262-94-9

2. Org-8282

3. Setiptiline [inn]

4. Org 8282

5. Mo 8282

6. 2,3,4,9-tetrahydro-2-methyl-1h-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine

7. Setiptiline (inn)

8. 4-methyl-4-azatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene

9. 7l38105z6e

10. Setiptilinum [latin]

11. Setiptilina [spanish]

12. Setiptilina

13. Setiptilinum

14. 2,3,4,9-tetrahydro-2-methyl-1h-dibenzo(3,4:6,7)cyclohepta(1,2-c)pyridine

15. 1h-dibenzo(3,4:6,7)cyclohepta(1,2-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-

16. Einecs 260-653-4

17. Brn 1650422

18. Unii-7l38105z6e

19. 1h-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine, 2,3,4,9-tetrahydro-2-methyl-

20. Tecipul [as Maleate]

21. Setiptiline [mi]

22. Setiptiline [mart.]

23. Setiptiline [who-dd]

24. Schembl211362

25. Chembl2104895

26. Dtxsid50205886

27. Chebi:135076

28. Zinc1482169

29. Cs-1181

30. Db09304

31. Ncgc00378937-01

32. Ncgc00378937-02

33. Org 8282;org8282;org-8282

34. Hy-32329

35. Ft-0674569

36. D08511

37. 262s949

38. A923887

39. L003337

40. Q6590424

41. 1,2,3,4-tetrahydro-2-methyl-1h-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine

42. 2-methyl-2,3,4,9-tetrahydro-1h-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine

43. 4-methyl-4-azatetracyclo[13.4.0.0^{2,7.0^{8,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 261.4 g/mol
Molecular Formula C19H19N
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass261.151749610 g/mol
Monoisotopic Mass261.151749610 g/mol
Topological Polar Surface Area3.2 Ų
Heavy Atom Count20
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of depression.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Setiptiline is a tertacyclic antidepressant. It acts to reduce the symptoms of major depressive disorder.


5.2 Mechanism of Action

Setiptiline is an antagonist at the 2 adrenergic receptor and at serotonin receptors. The antagonism of the 2 receptors likely relieves presynaptic inhibition of adrenergic neurotransmission, allowing for greater and longer sustained release of noradrenaline into the synapse. The antagonism of serotonin receptors may produce an upregulation of the receptors leading to an eventual increase in serotonergic signalling. The actual physiological mechanisms behind the antidepressant effect of setiptiline is unknown but the listed possibilities exist as likely explanations.


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Looking for 57262-94-9 / Setiptiline API manufacturers, exporters & distributors?

Setiptiline manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Setiptiline API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Setiptiline manufacturer or Setiptiline supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Setiptiline manufacturer or Setiptiline supplier.

PharmaCompass also assists you with knowing the Setiptiline API Price utilized in the formulation of products. Setiptiline API Price is not always fixed or binding as the Setiptiline Price is obtained through a variety of data sources. The Setiptiline Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Setiptiline

Synonyms

57262-94-9, Org-8282, Setiptiline [inn], Org 8282, Mo 8282, 2,3,4,9-tetrahydro-2-methyl-1h-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine

Cas Number

57262-94-9

Unique Ingredient Identifier (UNII)

7L38105Z6E

About Setiptiline

Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). In Japan, the company Mochida started its commercialization for the treatment of depression started in 1989.

Setiptiline Manufacturers

A Setiptiline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Setiptiline, including repackagers and relabelers. The FDA regulates Setiptiline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Setiptiline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Setiptiline Suppliers

A Setiptiline supplier is an individual or a company that provides Setiptiline active pharmaceutical ingredient (API) or Setiptiline finished formulations upon request. The Setiptiline suppliers may include Setiptiline API manufacturers, exporters, distributors and traders.

Setiptiline GMP

Setiptiline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Setiptiline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Setiptiline GMP manufacturer or Setiptiline GMP API supplier for your needs.

Setiptiline CoA

A Setiptiline CoA (Certificate of Analysis) is a formal document that attests to Setiptiline's compliance with Setiptiline specifications and serves as a tool for batch-level quality control.

Setiptiline CoA mostly includes findings from lab analyses of a specific batch. For each Setiptiline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Setiptiline may be tested according to a variety of international standards, such as European Pharmacopoeia (Setiptiline EP), Setiptiline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Setiptiline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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