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Chemistry

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Also known as: 219861-08-2, Lexapro, (s)-citalopram oxalate, Cipralex, Escitalopram (oxalate), (s)-(+)citalopram oxalate
Molecular Formula
C22H23FN2O5
Molecular Weight
414.4  g/mol
InChI Key
KTGRHKOEFSJQNS-BDQAORGHSA-N
FDA UNII
5U85DBW7LO

Escitalopram Oxalate
S-enantiomer of CITALOPRAM. Belongs to a class of drugs known as SELECTIVE SEROTONIN REUPTAKE INHIBITORS, used to treat depression and generalized anxiety disorder.
1 2D Structure

Escitalopram Oxalate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;oxalic acid
2.1.2 InChI
InChI=1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1
2.1.3 InChI Key
KTGRHKOEFSJQNS-BDQAORGHSA-N
2.1.4 Canonical SMILES
CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O
2.1.5 Isomeric SMILES
CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O
2.2 Other Identifiers
2.2.1 UNII
5U85DBW7LO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Escitalopram

2. Lexapro

2.3.2 Depositor-Supplied Synonyms

1. 219861-08-2

2. Lexapro

3. (s)-citalopram Oxalate

4. Cipralex

5. Escitalopram (oxalate)

6. (s)-(+)citalopram Oxalate

7. Lu 26-054-0

8. Escitalopram (as Oxalate)

9. Citalopram Oxalate, (s)-

10. Nsc-758934

11. 5u85dbw7lo

12. Lu-26-054-0

13. (s)-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Oxalate

14. (1s)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3h-2-benzofuran-5-carbonitrile;oxalic Acid

15. Lu-26-054-o

16. Ncgc00095903-01

17. Dsstox_cid_26003

18. Dsstox_rid_81282

19. S-(+)-1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile Oxalate

20. Dsstox_gsid_46003

21. S-(+)-5-isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, Oxalate

22. Cas-219861-08-2

23. Escitalopram Oxalate [usan]

24. Gaudium

25. Entact

26. (s)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Oxalate

27. Lexapro (tn)

28. Escitalopram Oxalate Inn

29. Unii-5u85dbw7lo

30. Schembl35123

31. Mls001401408

32. Spectrum1505216

33. (+)-(s)-citalopram Oxalate

34. Mld-55

35. (s)-citalopram Oxalate- Bio-x

36. Chembl1200322

37. Dtxsid1046003

38. Escitalopram Oxalate (jan/usp)

39. Escitalopram Oxalate [mi]

40. C20h21fn2o.c2h2o4

41. Escitalopram Oxalate [usan:usp]

42. Escitalopram Oxalate [jan]

43. Hms2051d11

44. Hms2231m16

45. Hms3370i17

46. Hms3393d11

47. Hms3713d16

48. Pharmakon1600-01505216

49. Bcp05686

50. Escitalopram Oxalate [vandf]

51. Tox21_111535

52. Ccg-39559

53. Escitalopram Oxalate [mart.]

54. Hy-14258a

55. Mfcd06407826

56. Nsc758934

57. Escitalopram Oxalate [usp-rs]

58. Escitalopram Oxalate [who-dd]

59. Akos016340275

60. Tox21_111535_1

61. Ac-6770

62. Cs-2054

63. Ks-1263

64. Nc00194

65. Nsc 758934

66. Sb17454

67. Ncgc00178555-02

68. 5-isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, (1s)-, Ethanedioate (1:1)

69. Bc164423

70. Escitalopram Oxalate [orange Book]

71. Smr000469191

72. Escitalopram Oxalate [ep Monograph]

73. Escitalopram Oxalate [usp Monograph]

74. E0958

75. D02567

76. Escitalopram Oxalate, >=98% (hplc), Powder

77. 861e082

78. A852070

79. Sr-01000763053

80. Sr-01000763053-3

81. Q27262882

82. Escitalopram Oxalate, Europepharmacopoeia (ep) Reference Standard

83. Escitalopram Oxalate, United States Pharmacopeia (usp) Reference Standard

84. Escitalopram For System Suitability, Europepharmacopoeia (ep) Reference Standard

85. Escitalopram Oxalate, Pharmaceutical Secondary Standard; Certified Reference Material

86. (+)-(s)-1-[3-(dimethylamino)propyl] -1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancar Bonitrile Oxalate

87. (+)-(s)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile Oxalate

88. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran-carbonitrile Oxalate

89. 5-isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, (1s)-,ethanedioate (1:1)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 414.4 g/mol
Molecular Formula C22H23FN2O5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass414.15910000 g/mol
Monoisotopic Mass414.15910000 g/mol
Topological Polar Surface Area111 Ų
Heavy Atom Count30
Formal Charge0
Complexity537
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameEscitalopram oxalate
PubMed HealthEscitalopram (By mouth)
Drug ClassesAntianxiety, Antidepressant
Drug LabelEscitalopramoxalate USPis an orally administered selective serotonin reuptake inhibitor (SSRI). Escitalopram is the pure S-enantiomer (single isomer) of the racemic bicyclic phthalane derivative citalopram. Escitalopram oxalate is designated S-(+...
Active IngredientEscitalopram oxalate
Dosage FormTablet; Solution
Routeoral; Oral
Strength5mg; eq 5mg base; eq 5mg base/5ml; 10mg; eq 20mg base; eq 10mg base; 20mg
Market StatusTentative Approval; Prescription
CompanyWatson Labs; Amneal Pharms; Mylan Pharma; Teva Pharms; Macleods Pharms; Caraco; Jubilant Generics; Sti Pharma; Apotex; Accord Hlthcare; Hetero Labs Ltd Iii; Aurobindo Pharma; Teva Pharms Usa; Taro; Torrent Pharms; Lupin; Zydus Pharms Usa; Dr Reddys Labs;

2 of 4  
Drug NameLexapro
Drug LabelLexapro (escitalopram oxalate) is an orally administered selective serotonin reuptake inhibitor (SSRI). Escitalopram is the pure S-enantiomer (single isomer) of the racemic bicyclic phthalane derivative citalopram. Escitalopram oxalate is designate...
Active IngredientEscitalopram oxalate
Dosage FormTablet; Solution
Routeoral; Oral
Strengtheq 5mg base; eq 5mg base/5ml; eq 20mg base; eq 10mg base
Market StatusPrescription
CompanyForest Labs

3 of 4  
Drug NameEscitalopram oxalate
PubMed HealthEscitalopram (By mouth)
Drug ClassesAntianxiety, Antidepressant
Drug LabelEscitalopramoxalate USPis an orally administered selective serotonin reuptake inhibitor (SSRI). Escitalopram is the pure S-enantiomer (single isomer) of the racemic bicyclic phthalane derivative citalopram. Escitalopram oxalate is designated S-(+...
Active IngredientEscitalopram oxalate
Dosage FormTablet; Solution
Routeoral; Oral
Strength5mg; eq 5mg base; eq 5mg base/5ml; 10mg; eq 20mg base; eq 10mg base; 20mg
Market StatusTentative Approval; Prescription
CompanyWatson Labs; Amneal Pharms; Mylan Pharma; Teva Pharms; Macleods Pharms; Caraco; Jubilant Generics; Sti Pharma; Apotex; Accord Hlthcare; Hetero Labs Ltd Iii; Aurobindo Pharma; Teva Pharms Usa; Taro; Torrent Pharms; Lupin; Zydus Pharms Usa; Dr Reddys Labs;

4 of 4  
Drug NameLexapro
Drug LabelLexapro (escitalopram oxalate) is an orally administered selective serotonin reuptake inhibitor (SSRI). Escitalopram is the pure S-enantiomer (single isomer) of the racemic bicyclic phthalane derivative citalopram. Escitalopram oxalate is designate...
Active IngredientEscitalopram oxalate
Dosage FormTablet; Solution
Routeoral; Oral
Strengtheq 5mg base; eq 5mg base/5ml; eq 20mg base; eq 10mg base
Market StatusPrescription
CompanyForest Labs

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Selective Serotonin Reuptake Inhibitors

Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Serotonin Uptake Inhibitors [MoA]; Serotonin Reuptake Inhibitor [EPC]

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COLTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SHODHANA LABORATORIES PRIVATE LTD","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"0.3","unit":"KGS","unitRateFc":"5333.3","totalValueFC":"1614.9","currency":"USD","unitRateINR":"460800","date":"23-Apr-2025","totalValueINR":"138240","totalValueInUsd":"1614.9","indian_port":"Hyderabad Air","hs_no":"29321990","bill_no":"9662682","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"19-21\/F GUOTAI BLDG RENMIN ROAD (M) ZHANGJIAGANG CITY JIANGSU CHINA SDNF CN","customerAddress":"PLOT NO. 705, ADITYA TRADE CENTRE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1747247400,"product":"ESCITALOPRAM OXALATE USP","address":"NO.8-2-248\/1\/7\/64, PLOT NO.64,","city":"PUNJAGUTTA, HYDERABAD, AP.","supplier":"HETERO LABS LTDUNIT IXHETERO INFRASTRUCTURESEZLTD","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"GRAVITI PHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"697.74","actualQuantity":"697.74","unit":"KGS","unitRateFc":"438.8","totalValueFC":"307457.8","currency":"USD","unitRateINR":"37543.5","date":"15-May-2025","totalValueINR":"26195601.69","totalValueInUsd":"307457.8","indian_port":"Vizag-HIPL SEZ","hs_no":"29269090","bill_no":"2059951","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"PLOT-NO.2,NAKKAPALLI (MANDAL), N.NARASAPURAMVILLAGE,ANAKAPALLIDIST SDNF India","customerAddress":"NO.8-2-248\/1\/7\/64, PLOT NO.64,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748629800,"product":"ESCITALOPRAM OXALATE (CAS NO:219861-08-2) ESCITALOPRAM OXALATE (CAS NO:219861-08-2)","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"ZHEJIANG HUAHAI PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"NANJING","customer":"AUROBINDO PHARMA LTD","customerCountry":"INDIA","quantity":"320.00","actualQuantity":"320","unit":"KGS","unitRateFc":"397.3","totalValueFC":"128933.2","currency":"USD","unitRateINR":"34328.7","date":"31-May-2025","totalValueINR":"10985190.6","totalValueInUsd":"128933.2","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"2397575","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NANJING","supplierAddress":"XUNQIAO, LINHAI, ZHEJIANG, 317024 C HINA SDNF China","customerAddress":"PLOT NO.2, MAITRIVIHAR,"}]
04-Jan-2022
31-May-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 10MG BASE

USFDA APPLICATION NUMBER - 21323

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DOSAGE - TABLET;ORAL - EQ 20MG BASE

USFDA APPLICATION NUMBER - 21323

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DOSAGE - TABLET;ORAL - EQ 5MG BASE

USFDA APPLICATION NUMBER - 21323

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DOSAGE - SOLUTION;ORAL - EQ 5MG BASE/5ML **Fe...DOSAGE - SOLUTION;ORAL - EQ 5MG BASE/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21365

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ABOUT THIS PAGE

Looking for 219861-08-2 / Escitalopram Oxalate API manufacturers, exporters & distributors?

Escitalopram Oxalate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Escitalopram Oxalate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Escitalopram Oxalate manufacturer or Escitalopram Oxalate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Escitalopram Oxalate manufacturer or Escitalopram Oxalate supplier.

PharmaCompass also assists you with knowing the Escitalopram Oxalate API Price utilized in the formulation of products. Escitalopram Oxalate API Price is not always fixed or binding as the Escitalopram Oxalate Price is obtained through a variety of data sources. The Escitalopram Oxalate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Escitalopram Oxalate

Synonyms

219861-08-2, Lexapro, (s)-citalopram oxalate, Cipralex, Escitalopram (oxalate), (s)-(+)citalopram oxalate

Cas Number

219861-08-2

Unique Ingredient Identifier (UNII)

5U85DBW7LO

About Escitalopram Oxalate

S-enantiomer of CITALOPRAM. Belongs to a class of drugs known as SELECTIVE SEROTONIN REUPTAKE INHIBITORS, used to treat depression and generalized anxiety disorder.

Seroplex Manufacturers

A Seroplex manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Seroplex, including repackagers and relabelers. The FDA regulates Seroplex manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Seroplex API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Seroplex manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Seroplex Suppliers

A Seroplex supplier is an individual or a company that provides Seroplex active pharmaceutical ingredient (API) or Seroplex finished formulations upon request. The Seroplex suppliers may include Seroplex API manufacturers, exporters, distributors and traders.

click here to find a list of Seroplex suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Seroplex USDMF

A Seroplex DMF (Drug Master File) is a document detailing the whole manufacturing process of Seroplex active pharmaceutical ingredient (API) in detail. Different forms of Seroplex DMFs exist exist since differing nations have different regulations, such as Seroplex USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Seroplex DMF submitted to regulatory agencies in the US is known as a USDMF. Seroplex USDMF includes data on Seroplex's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Seroplex USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Seroplex suppliers with USDMF on PharmaCompass.

Seroplex JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Seroplex Drug Master File in Japan (Seroplex JDMF) empowers Seroplex API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Seroplex JDMF during the approval evaluation for pharmaceutical products. At the time of Seroplex JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Seroplex suppliers with JDMF on PharmaCompass.

Seroplex KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Seroplex Drug Master File in Korea (Seroplex KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Seroplex. The MFDS reviews the Seroplex KDMF as part of the drug registration process and uses the information provided in the Seroplex KDMF to evaluate the safety and efficacy of the drug.

After submitting a Seroplex KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Seroplex API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Seroplex suppliers with KDMF on PharmaCompass.

Seroplex CEP

A Seroplex CEP of the European Pharmacopoeia monograph is often referred to as a Seroplex Certificate of Suitability (COS). The purpose of a Seroplex CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Seroplex EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Seroplex to their clients by showing that a Seroplex CEP has been issued for it. The manufacturer submits a Seroplex CEP (COS) as part of the market authorization procedure, and it takes on the role of a Seroplex CEP holder for the record. Additionally, the data presented in the Seroplex CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Seroplex DMF.

A Seroplex CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Seroplex CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Seroplex suppliers with CEP (COS) on PharmaCompass.

Seroplex WC

A Seroplex written confirmation (Seroplex WC) is an official document issued by a regulatory agency to a Seroplex manufacturer, verifying that the manufacturing facility of a Seroplex active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Seroplex APIs or Seroplex finished pharmaceutical products to another nation, regulatory agencies frequently require a Seroplex WC (written confirmation) as part of the regulatory process.

click here to find a list of Seroplex suppliers with Written Confirmation (WC) on PharmaCompass.

Seroplex NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Seroplex as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Seroplex API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Seroplex as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Seroplex and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Seroplex NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Seroplex suppliers with NDC on PharmaCompass.

Seroplex GMP

Seroplex Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Seroplex GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Seroplex GMP manufacturer or Seroplex GMP API supplier for your needs.

Seroplex CoA

A Seroplex CoA (Certificate of Analysis) is a formal document that attests to Seroplex's compliance with Seroplex specifications and serves as a tool for batch-level quality control.

Seroplex CoA mostly includes findings from lab analyses of a specific batch. For each Seroplex CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Seroplex may be tested according to a variety of international standards, such as European Pharmacopoeia (Seroplex EP), Seroplex JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Seroplex USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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