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1. Abbottselsun
2. Bioselenium
3. Caspiselenio
4. Ellsurex
5. Exsel
6. Glo-sel
7. Head And Shoulders
8. Iosel-250
9. Lenium
10. Selenium Sulfide
11. Selenium Sulfide (ses2)
12. Selsun
13. Selsun Blue
14. Selukos
15. Selun Gold
16. Versel
1. 7488-56-4
2. Selenium Disulphide
3. Selenium(iv) Disulfide
4. Selenium(iv) Sulfide
5. Seledruff
6. Selenium Sulfide, Micronized
7. Selenium Sulphide, Micronized
8. Selenium(iv) Sulphide
9. Selenium(iv) Disulphide
10. Selenium Sulfide (usp)
11. Selenium Sulfide [usp]
12. Selenium Sulphide (ses2)
13. Selsun Blue
14. Selenium Sulfide (ses(sub 2))
15. Z69d9e381q
16. Sebusan
17. Selenex
18. Selenix
19. Selukos
20. Lenium
21. Seleen
22. Sulfur Selenide
23. Zeran
24. Sul-blue
25. Sel-o-rinse
26. Selenium Sulfide (ses2)
27. Selen(iv) Sulfid
28. Selenium Sulfide Ses2
29. Caswell No. 732a
30. Selendisulfid
31. Tersi
32. Mfcd00011227
33. Selenii Disulfidum
34. Hsdb 6367
35. Selenium(iv) Disulfide (1:2)
36. Einecs 231-303-8
37. Un2657
38. Rcra Waste No. U205
39. Epa Pesticide Chemical Code 072003
40. Unii-z69d9e381q
41. Exsel (tn)
42. Selenium Disulfide [mi]
43. Selenium Sulfide [hsdb]
44. Selenium Sulfide [inci]
45. Chembl1200680
46. Dtxsid0042375
47. Selenium Sulfide [vandf]
48. Selenium Disulfide [hsdb]
49. Selenium Sulfide [mart.]
50. Chebi:135934
51. Selenium Sulfide [usp-rs]
52. Selenium Sulfide [who-dd]
53. Selenium Disulfide [who-ip]
54. Selenium Sulfide [orange Book]
55. Db00971
56. Selenium Disulfide [green Book]
57. Selenium Sulfide [usp Monograph]
58. Selenium Disulfide [ep Monograph]
59. Selenii Disulfidum [who-ip Latin]
60. Selenium Disulfide [un2657] [poison]
61. D05815
62. Q56249646
| Molecular Weight | 143.1 g/mol |
|---|---|
| Molecular Formula | S2Se |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 143.86066 g/mol |
| Monoisotopic Mass | 143.86066 g/mol |
| Topological Polar Surface Area | 64.2 Ų |
| Heavy Atom Count | 3 |
| Formal Charge | 0 |
| Complexity | 18.3 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
The treatment of pityriasis versicolor by the topical application of selenium sulfide 1% was studied in two groups of patients. Diagnosis and response to therapy was determined by clinical observation. Wood's light fluorescence, and direct microscopic examination. The efficacy of three different therapeutic regimes was studied in one group by the application of the drug to the entire skin for either five minutes, fifteen minutes, or twelve hours for eighteen days. Each method proved equally effective in resolving the infection. Therefore, the cutaneous application of selenium sulfide 1 % for five minutes daily for eighteen days is the recommended treatment for pityriasis versicolor. The percutaneous absorption of selenium sulfide was also studied in another groups who applied the drug to the entire skin for five minutes for eighteen days. Fluorimetric analysis of urinary samples collected on the third and thirteenth days of treatment revealed no significant increase in the excretion of selenium as compared to pretreatment levels. Systemic toxicity was not observed in any of the patients treated. The results suggest that the selenium sulfide is absorbed poorly from the skin and is a safe and effective therapy for pityriasis versicolor.
PMID:988451 Costa Martins JE et al; Med Cutan Ibero Lat Am 4 (2): 137-41 (1976)
A 1% lotion of selenium sulfide is used to relieve the itching and flaking of the scalp associated with dandruff. A 1% shampoo or 2.5% lotion of the drug is used for the control of dandruff and of seborrheic dermatitis of the scalp. Dandruff usually responds to treatment, but tends to relapse if therapy is discontinued. If dandruff is left untreated, the resulting problems are those of appearance, and generally no medical disability will result. A 2.5% lotion of selenium sulfide has also been used for the treatment of tinea versicolor.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3554
... As an ointment for application to the lid margins in treatment of Seborrheic blepharitis.
Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 808
Medication (Vet): Topically in eczemas and dermatomycoses.
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1456
Medication (Vet): For use on dogs as a cleansing shampoo and as an agent for removing skin debris associated with dry eczema, seborrhea, and nonspecific dermatoses. /Seleen Suspension, SE Se Shampoo, Dandrex /
FDA Center for Veterinary Medicine; Green Book On-Line. Search All Approved Drugs for "Selenium Disulfide." Available from, as of April 1, 2011: https://www.accessdata.fda.gov/scripts/animaldrugsatfda/
It is also not known whether selenium sulfide can cause fetal harm when administered to pregnant women. Selenium sulfide should be used during pregnancy only when clearly needed and should generally not be used for the treatment of tinea versicolor during pregnancy.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3554
Safety of selenium sulfide lotions in infants has not been established. A 1% selenium sulfide lotion should not be used in children younger than 2 years of age unless otherwise directed by a physician.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3554
Contact of preparations containing selenium sulfide with mucous membranes of the eye may cause irritation (e.g., stinging). Prolonged contact (e.g., overnight application) of preparations containing selenium sulfide with the skin may cause local irritation. When selenium sulfide is applied topically for the treatment of tinea versicolor, skin irritation may occur, especially in the genital areas and/or folds of the skin. Selenium sulfide lotions can cause rebound oiliness of the scalp; this effect has been reported following short-term application of a 2.5% lotion and following long-term application of a 1% lotion.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3554
Because of the risk of systemic toxicity, selenium sulfide lotions should not be applied to damaged skin (e.g., open lesions or acute inflammation or exudation of the scalp). Cutaneous sensitization of the scalp or adjacent areas has been reported; application of the drug should be discontinued if sensitization occurs. Since selenium sulfide may cause irritation of the genital areas and/or folds of the skin in patients with tinea versicolor, these areas should be rinsed thoroughly following topical application of the drug. Patients should be advised to avoid contact of the lotion with the eyes since irritation may occur; if the lotion does come in contact with the eye, the eye should be thoroughly rinsed with water. Patients should also be advised to discontinue the drug and contact a physician if the condition worsens or does not improve following regular use of selenium sulfide lotion as directed.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3554
For more Drug Warnings (Complete) data for SELENIUM DISULFIDE (8 total), please visit the HSDB record page.
For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp.
Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.
Dermatologic Agents
Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)
Absorption
There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.
Selenium sulfide does not appear to be absorbed percutaneously through intact skin following topical application to the scalp of a 1% lotion during usual shampooing conditions. The drug can be absorbed percutaneously when applied to damaged skin, and systemic toxicity may occur.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3554
The treatment of pityriasis versicolor by the topical application of selenium sulfide 1% was studied. ... The percutaneous absorption of selenium sulfide was studied in groups who applied the drug to the entire skin for five minutes for eighteen days. Fluorimetric analysis of urinary samples collected on the third and thirteenth days of treatment revealed no significant increase in the excretion of selenium as compared in any of the patients treated.
PMID:988451 Costa Martins JE et al; Med Cutan Ibero Lat Am 4 (2): 137-41 (1976)
... Selenium is absorbed through intact skin following overnight topical application of 2.5% selenium sulfide lotion. Selenium is then excreted, at least partially, in urine, for at least a week following treatment. Absorption and excretion of selenium vary on an individual basis. Selenium levels in urine following a single application of selenium sulfide lotion do not indicate that toxic amounts of selenium are being absorbed. Repeated treatments with selenium sulfide result in selenium concentrations in urine which are significantly higher than normal. ...
Farley J et al; J Environ Sci Health (A) 21 (6): 571-82 (1986)
Topical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.
... Selenium sulfide, when absorbed into epithelial tissue, is converted into selenium and sulfide ions, and that the selenium ions block the enzyme systems involved in the growth of epithelial tissue. Selenium sulfide has been shown to have a cytostatic (antimitotic) action resulting in a decreased rate of cell turnover in cells with normal or higher than normal turnover rates.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3554
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