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Chemistry

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Also known as: Secrepan, 1393-25-5, Secretin, human, Secretolin, Vitrum, Secreflow
Molecular Formula
C130H219N43O42
Molecular Weight
3056.4  g/mol
InChI Key
KKNIUBFRGPFELP-UHFFFAOYSA-N

Secretin
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)
1 2D Structure

Secretin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[5-amino-1-[[1-[[1-[[1-[[5-amino-1-[[2-[[1-[(1-carboxy-2-methylpropyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-amino-3-(1H-imidazol-2-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C130H219N43O42/c1-59(2)43-78(118(206)172-99(65(13)14)126(214)215)151-94(182)53-148-104(192)75(31-34-91(132)180)156-113(201)81(46-62(7)8)163-115(203)82(47-63(9)10)161-107(195)72(28-22-38-145-128(136)137)153-110(198)76(32-35-92(133)181)157-114(202)80(45-61(5)6)159-106(194)71(27-21-37-144-127(134)135)152-102(190)66(15)150-120(208)87(55-174)168-117(205)86(52-98(188)189)165-109(197)73(29-23-39-146-129(138)139)154-112(200)79(44-60(3)4)160-108(196)74(30-24-40-147-130(140)141)155-121(209)89(57-176)169-116(204)83(48-64(11)12)162-111(199)77(33-36-96(184)185)158-122(210)90(58-177)170-125(213)101(68(17)179)173-119(207)84(49-69-25-19-18-20-26-69)166-124(212)100(67(16)178)171-95(183)54-149-105(193)85(51-97(186)187)164-123(211)88(56-175)167-103(191)70(131)50-93-142-41-42-143-93/h18-20,25-26,41-42,59-68,70-90,99-101,174-179H,21-24,27-40,43-58,131H2,1-17H3,(H2,132,180)(H2,133,181)(H,142,143)(H,148,192)(H,149,193)(H,150,208)(H,151,182)(H,152,190)(H,153,198)(H,154,200)(H,155,209)(H,156,201)(H,157,202)(H,158,210)(H,159,194)(H,160,196)(H,161,195)(H,162,199)(H,163,203)(H,164,211)(H,165,197)(H,166,212)(H,167,191)(H,168,205)(H,169,204)(H,170,213)(H,171,183)(H,172,206)(H,173,207)(H,184,185)(H,186,187)(H,188,189)(H,214,215)(H4,134,135,144)(H4,136,137,145)(H4,138,139,146)(H4,140,141,147)
2.1.3 InChI Key
KKNIUBFRGPFELP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)CC(C(=O)NC(C(C)C)C(=O)O)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC2=NC=CN2)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Pig Secretin

2. Pig Secretin Citrate

3. Pig Secretin Maleate

4. Pig Secretin Pentacetate

5. Pig Secretin Sulfate

6. Secrepan

7. Secretin Citrate, Pig

8. Secretin Kabi

9. Secretin Maleate, Pig

10. Secretin Pentacetate, Pig

11. Secretin Sulfate, Pig

12. Secretin, Pig

13. Secretin-kabi

14. Secretinkabi

2.2.2 Depositor-Supplied Synonyms

1. Secrepan

2. 1393-25-5

3. Secretin, Human

4. Secretolin

5. Vitrum

6. Secreflow

7. Secretin-kabi

8. Secretina

9. Secretine

10. Secretinum

11. Secretin-ferring

12. Secretine [inn-french]

13. Secretinum [inn-latin]

14. Secretina [inn-spanish]

15. Einecs 215-733-3

16. Unii-88c55n56uu

17. Secretin [usan:inn:ban:dcf:jan]

18. Hormone Of The Duodenal Mucosa That Activates Pancreatic Secretion And Lowers The Blood Sugar Level

19. Schembl677502

20. Secretin Synthetic Human

21. Gtpl1155

22. Gtpl3643

23. Secretin (porcine), 15-l-glutamic Acid-16-glycine-

24. 88c55n56uu

25. Akos015896025

26. L-histidyl-l-seryl-l-alpha-aspartylglycyl-l-threonyl-l-phenylalanyl-l-threonyl-l-seryl-l-alpha-glutamyl-l-leucyl-l-seryl-l-arginyl-l-leucyl-l-arginyl-l-alpha-aspartyl-l-seryl-l-alanyl-l-arginyl-l-leucyl-l-glutaminyl-l-arginyl-l-leucyl-l-leucyl-l-glutaminylglycyl-l-leucyl-l-valinamide

27. L-histidyl-l-seryl-l-alpha-aspartylglycyl-l-threonyl-l-phenylalanyl-l-threonyl-l-seryl-l-alpha-glutamyl-l-leucyl-l-seryl-l-arginyl-l-leucyl-l-arginyl-l-alpha-glutamylglycyl-l-alanyl-l-arginyl-l-leucyl-l-glutaminyl-l-arginyl-l-leucyl-l-leucyl-l-glutaminylglycyl-l-leucyl-l-valinamide

28. Q27088772

2.3 Create Date
2007-07-03
3 Chemical and Physical Properties
Molecular Weight 3056.4 g/mol
Molecular Formula C130H219N43O42
XLogP3-13.4
Hydrogen Bond Donor Count52
Hydrogen Bond Acceptor Count48
Rotatable Bond Count109
Exact Mass3055.6356330 g/mol
Monoisotopic Mass3054.6322782 g/mol
Topological Polar Surface Area1420 Ų
Heavy Atom Count215
Formal Charge0
Complexity6980
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count27
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameSecreflo
Active IngredientSecretin
Dosage FormFor solution
Routeintravenous
Strength16ugm/vial
Market StatusPrescription
CompanyChirhoclin

2 of 2  
Drug NameSecreflo
Active IngredientSecretin
Dosage FormFor solution
Routeintravenous
Strength16ugm/vial
Market StatusPrescription
CompanyChirhoclin

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Gastrointestinal Agents

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)


Hormones

Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects. (See all compounds classified as Hormones.)


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ABOUT THIS PAGE

Looking for 1393-25-5 / Secretin API manufacturers, exporters & distributors?

Secretin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Secretin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Secretin manufacturer or Secretin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Secretin manufacturer or Secretin supplier.

PharmaCompass also assists you with knowing the Secretin API Price utilized in the formulation of products. Secretin API Price is not always fixed or binding as the Secretin Price is obtained through a variety of data sources. The Secretin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Secretin

Synonyms

Secrepan, 1393-25-5, Secretin, human, Secretolin, Vitrum, Secreflow

Cas Number

1393-25-5

About Secretin

A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)

SECRETIN-FERRING Manufacturers

A SECRETIN-FERRING manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of SECRETIN-FERRING, including repackagers and relabelers. The FDA regulates SECRETIN-FERRING manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. SECRETIN-FERRING API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of SECRETIN-FERRING manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

SECRETIN-FERRING Suppliers

A SECRETIN-FERRING supplier is an individual or a company that provides SECRETIN-FERRING active pharmaceutical ingredient (API) or SECRETIN-FERRING finished formulations upon request. The SECRETIN-FERRING suppliers may include SECRETIN-FERRING API manufacturers, exporters, distributors and traders.

click here to find a list of SECRETIN-FERRING suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

SECRETIN-FERRING USDMF

A SECRETIN-FERRING DMF (Drug Master File) is a document detailing the whole manufacturing process of SECRETIN-FERRING active pharmaceutical ingredient (API) in detail. Different forms of SECRETIN-FERRING DMFs exist exist since differing nations have different regulations, such as SECRETIN-FERRING USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A SECRETIN-FERRING DMF submitted to regulatory agencies in the US is known as a USDMF. SECRETIN-FERRING USDMF includes data on SECRETIN-FERRING's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The SECRETIN-FERRING USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of SECRETIN-FERRING suppliers with USDMF on PharmaCompass.

SECRETIN-FERRING GMP

SECRETIN-FERRING Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of SECRETIN-FERRING GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right SECRETIN-FERRING GMP manufacturer or SECRETIN-FERRING GMP API supplier for your needs.

SECRETIN-FERRING CoA

A SECRETIN-FERRING CoA (Certificate of Analysis) is a formal document that attests to SECRETIN-FERRING's compliance with SECRETIN-FERRING specifications and serves as a tool for batch-level quality control.

SECRETIN-FERRING CoA mostly includes findings from lab analyses of a specific batch. For each SECRETIN-FERRING CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

SECRETIN-FERRING may be tested according to a variety of international standards, such as European Pharmacopoeia (SECRETIN-FERRING EP), SECRETIN-FERRING JP (Japanese Pharmacopeia) and the US Pharmacopoeia (SECRETIN-FERRING USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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