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Chemistry

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Also known as: 1316214-52-4, Acy-1215, Rocilinostat, 2-(diphenylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide, Rocilinostat (acy-1215), Acy-63
Molecular Formula
C24H27N5O3
Molecular Weight
433.5  g/mol
InChI Key
QGZYDVAGYRLSKP-UHFFFAOYSA-N
FDA UNII
WKT909C62B

Ricolinostat
Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.
1 2D Structure

Ricolinostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
2.1.2 InChI
InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
2.1.3 InChI Key
QGZYDVAGYRLSKP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
2.2 Other Identifiers
2.2.1 UNII
WKT909C62B
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(diphenylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

2. Acy-1215

3. Rocilinostat

2.3.2 Depositor-Supplied Synonyms

1. 1316214-52-4

2. Acy-1215

3. Rocilinostat

4. 2-(diphenylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

5. Rocilinostat (acy-1215)

6. Acy-63

7. Ricolinostat (acy-1215)

8. N-[7-(hydroxyamino)-7-oxoheptyl]-2-(n-phenylanilino)pyrimidine-5-carboxamide

9. Wkt909c62b

10. 7-{[2-(diphenylamino)pyrimidin-5-yl]formamido}-n-hydroxyheptanamide

11. Mfcd22666356

12. 2-(diphenylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide

13. 5-pyrimidinecarboxamide, 2-(diphenylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)-

14. Ricolinostat [usan]

15. Ricolinostat [usan:inn]

16. Unii-wkt909c62b

17. 5-pyrimidinecarboxamide, 2-(diphenylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]-

18. Acy1215

19. Ricolinostat (usan/inn)

20. Ricolinostat [inn]

21. 2-(diphenylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide

22. Mls006011181

23. Ricolinostat [who-dd]

24. Schembl574580

25. Gtpl7010

26. Chembl2364628

27. Chebi:95073

28. Dtxsid40157148

29. Ex-a139

30. Hms3426c09

31. Hms3653f17

32. Hms3886l21

33. Acy 1215

34. Amy38185

35. Bcp06028

36. Bdbm50439674

37. Nsc767952

38. S8001

39. Zinc89630354

40. Akos024259260

41. Ccg-269054

42. Cs-0965

43. Db12376

44. Nsc-767952

45. Sb17054

46. Ncgc00345802-01

47. Ncgc00345802-05

48. Ac-30258

49. As-73344

50. Ba164806

51. Hy-16026

52. Smr004702950

53. Sy096614

54. Sw219836-1

55. D10661

56. J-690127

57. Q27088553

58. Ah4

59. Us8609678, 2-(diphenylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [26]

2.4 Create Date
2011-08-31
3 Chemical and Physical Properties
Molecular Weight 433.5 g/mol
Molecular Formula C24H27N5O3
XLogP33.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Exact Mass433.21138974 g/mol
Monoisotopic Mass433.21138974 g/mol
Topological Polar Surface Area107 Ų
Heavy Atom Count32
Formal Charge0
Complexity538
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Histone Deacetylase Inhibitors

Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. (See all compounds classified as Histone Deacetylase Inhibitors.)


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ABOUT THIS PAGE

Looking for 1316214-52-4 / Ricolinostat API manufacturers, exporters & distributors?

Ricolinostat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ricolinostat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ricolinostat manufacturer or Ricolinostat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ricolinostat manufacturer or Ricolinostat supplier.

PharmaCompass also assists you with knowing the Ricolinostat API Price utilized in the formulation of products. Ricolinostat API Price is not always fixed or binding as the Ricolinostat Price is obtained through a variety of data sources. The Ricolinostat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ricolinostat

Synonyms

1316214-52-4, Acy-1215, Rocilinostat, 2-(diphenylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide, Rocilinostat (acy-1215), Acy-63

Cas Number

1316214-52-4

Unique Ingredient Identifier (UNII)

WKT909C62B

About Ricolinostat

Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.

Ricolinostat Manufacturers

A Ricolinostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ricolinostat, including repackagers and relabelers. The FDA regulates Ricolinostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ricolinostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ricolinostat Suppliers

A Ricolinostat supplier is an individual or a company that provides Ricolinostat active pharmaceutical ingredient (API) or Ricolinostat finished formulations upon request. The Ricolinostat suppliers may include Ricolinostat API manufacturers, exporters, distributors and traders.

Ricolinostat GMP

Ricolinostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ricolinostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ricolinostat GMP manufacturer or Ricolinostat GMP API supplier for your needs.

Ricolinostat CoA

A Ricolinostat CoA (Certificate of Analysis) is a formal document that attests to Ricolinostat's compliance with Ricolinostat specifications and serves as a tool for batch-level quality control.

Ricolinostat CoA mostly includes findings from lab analyses of a specific batch. For each Ricolinostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ricolinostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Ricolinostat EP), Ricolinostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ricolinostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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