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    Chemistry

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    Also known as: Retatrutide api
    Retatrutide (LY3437943) is a biologic entity that acts as a triagonist for the gastric inhibitory polypeptide (GIP) receptor, the glucagon-like peptide-1 (GLP-1) receptor and the glucagon receptor. It is an investigational drug developed by Eli Lilly for obesity, type 2 diabetes, and related metabolic disorders.

    Drugs in Development

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    Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight

    Details:

    LY3437943 (Retatrutide) is a peptide drug, which is currently being evaluated in Phase II clinical studies for the treatment of obesity.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Nutrition and Weight Loss Brand Name: LY3437943

    Study Phase: Phase IIProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 12, 2026

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    01

    Hudson Biotech

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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Nutrition and Weight Loss

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight

    Details : LY3437943 (Retatrutide) is a peptide drug, which is currently being evaluated in Phase II clinical studies for the treatment of obesity.

    Product Name : LY3437943

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    March 12, 2026

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    A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight

    Details:

    Retatrutide is a peptide drug, which is currently being evaluated in Phase III clinical studies for the treatment of obesity.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Nutrition and Weight Loss Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable January 22, 2026

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    02

    Eli Lilly

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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Nutrition and Weight Loss

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Ove...

    Details : Retatrutide is a peptide drug, which is currently being evaluated in Phase III clinical studies for the treatment of obesity.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    January 22, 2026

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    A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

    Details:

    Retatrutide is a peptide drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Obesity.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Nutrition and Weight Loss Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable November 18, 2025

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    03

    Eli Lilly

    U.S.A
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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Nutrition and Weight Loss

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

    Details : Retatrutide is a peptide drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Obesity.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    November 18, 2025

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    A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

    Details:

    Tirzepatide is a Peptide, Unconjugated drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Non-alcoholic Fatty Liver Disease.


    Lead Product(s): Tirzepatide,Retatrutide

    Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable September 10, 2025

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    04

    Eli Lilly

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    Lead Product(s) : Tirzepatide,Retatrutide

    Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liv...

    Details : Tirzepatide is a Peptide, Unconjugated drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Non-alcoholic Fatty Liver Disease.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    September 10, 2025

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    Study of Retatrutide LY3437943 in Obesity or Overweight Patient with Chronic Low Back Pain

    Details:

    Retatrutide is a Peptide drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Obesity.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Nutrition and Weight Loss Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 24, 2025

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    05

    Eli Lilly

    U.S.A
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    AACR Annual meeting
    Not Confirmed

    Eli Lilly

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    Not Confirmed
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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Nutrition and Weight Loss

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Study of Retatrutide LY3437943 in Obesity or Overweight Patient with Chronic Low Back Pain

    Details : Retatrutide is a Peptide drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Obesity.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    June 24, 2025

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    Retatrutide Effect On Insulin Secretion and Sensitivity In T2DM Adults

    Details:

    Retatrutide is a Peptide drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Diabetes Mellitus.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Endocrinology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable May 21, 2025

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    06

    Eli Lilly

    U.S.A
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    Not Confirmed

    Eli Lilly

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    Not Confirmed
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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Endocrinology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Retatrutide Effect On Insulin Secretion and Sensitivity In T2DM Adults

    Details : Retatrutide is a Peptide drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Diabetes Mellitus.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    May 21, 2025

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    Retatrutide Response to Hypoglycemia In Type 2 Diabetes

    Details:

    Retatrutide is a Peptide drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Diabetes Mellitus, Type 2.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Endocrinology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable May 21, 2025

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    07

    Eli Lilly

    U.S.A
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    Not Confirmed

    Eli Lilly

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    Not Confirmed
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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Endocrinology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Retatrutide Response to Hypoglycemia In Type 2 Diabetes

    Details : Retatrutide is a Peptide drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Diabetes Mellitus, Type 2.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    May 21, 2025

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    A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity

    Details:

    Retatrutide is a Peptide drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Obesity.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Nutrition and Weight Loss Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 05, 2025

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    08

    Eli Lilly

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    Not Confirmed

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    Not Confirmed
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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Nutrition and Weight Loss

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obes...

    Details : Retatrutide is a Peptide drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Obesity.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    March 05, 2025

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    To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy Participants

    Details:

    Retatrutide is a Peptide drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.


    Lead Product(s): Retatrutide,Metoprolol Tartrate

    Therapeutic Area: Undisclosed Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable February 05, 2025

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    09

    Eli Lilly

    U.S.A
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    Not Confirmed

    Eli Lilly

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    Not Confirmed
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    Lead Product(s) : Retatrutide,Metoprolol Tartrate

    Therapeutic Area : Undisclosed

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy Par...

    Details : Retatrutide is a Peptide drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    February 05, 2025

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    CDSCO Panel Approves Eli Lilly's Protocol Amendment Proposal for Retatrutide Study

    Details:

    LY3437943 (retatrutide) is a GCGR/GLP-1R agonist synthetic peptide candidate, which is currently being evaluated for the treatment of Atherosclerotic Cardiovascular Disease in adult.


    Lead Product(s): Retatrutide,Inapplicable

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Peptide, Unconjugated

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable January 19, 2025

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    10

    Eli Lilly

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    Lead Product(s) : Retatrutide,Inapplicable

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    CDSCO Panel Approves Eli Lilly's Protocol Amendment Proposal for Retatrutide Study

    Details : LY3437943 (retatrutide) is a GCGR/GLP-1R agonist synthetic peptide candidate, which is currently being evaluated for the treatment of Atherosclerotic Cardiovascular Disease in adult.

    Product Name : Undisclosed

    Product Type : Peptide, Unconjugated

    Upfront Cash : Inapplicable

    January 19, 2025

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