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1. Molevac
2. Pamoxan
3. Povanyl
4. Pyrcon
5. Pyrvinium Iodide
6. Pyrvinium Monohydroxide
7. Pyrvinium Pamoate
8. Pyrvinium Pamoate (2:1)
9. Vankin
10. Vanquin
1. 7187-62-4
2. Pyrvinum
3. Pyrvinium (cation)
4. Pyrvinium Ion
5. Pyrvinium Cation
6. Pyrvinum (base)
7. Hsdb 3178
8. Chebi:8687
9. 6b9991flu3
10. 2-[(e)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-n,n,1-trimethylquinolin-1-ium-6-amine
11. Quinolinium, 6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)ethenyl)-1-methyl-
12. Pyrvinium-pamoate
13. Pyrvinium [hsdb]
14. 6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)ethenyl)-1-methylquinolinium
15. Unii-6b9991flu3
16. Chembl1201303
17. Dtxsid2043795
18. Zinc3831401
19. Db06816
20. Quinolinium, 6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-methyl-
21. C07412
22. Ab00053809_02
23. Q264039
24. 2-[(e)-2-(2,5-dimethyl-1-phenyl-pyrrol-3-yl)vinyl]-n,n,1-trimethyl-quinolin-1-ium-6-amine
25. 6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)vinyl)-1-methylquinolinium
26. 6-(dimethylamino)-2-[(e)-2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)ethenyl]-1-methylquinolinium
| Molecular Weight | 382.5 g/mol |
|---|---|
| Molecular Formula | C26H28N3+ |
| XLogP3 | 5.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 4 |
| Exact Mass | 382.228322906 g/mol |
| Monoisotopic Mass | 382.228322906 g/mol |
| Topological Polar Surface Area | 12 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 1 |
| Complexity | 552 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Anthelmintics; Fluorescent Dyes
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
FOR CONTROL OF PINWORM INFESTATION IN CHILDREN & ADULTS PYRVINIUM PAMOATE IS GIVEN ORALLY IN SINGLE DOSE ... SECOND DOSE SHOULD BE ADMIN 2 WK LATER, TO ELIM WORMS THAT HAVE DEVELOPED FROM OVA INGESTED AFTER FIRST DOSE. /PAMOATE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1030
...OCCUPANTS OF ENTIRE HOUSEHOLD MAY BE TREATED RATHER THAN INVESTIGATING EACH MEMBER BY ANAL SWABS. INVESTIGATIONS ON EFFECT OF THIS DRUG ON STRONGYLOIDIASIS HAVE SHOWN PROMISING RESULTS. ... BECAUSE OF STAINING QUALITY OF DRUG, TABLETS SHOULD BE SWALLOWED IMMEDIATELY WITHOUT CHEWING.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1030
PARENTS & PT SHOULD BE INFORMED THAT DRUG WILL COLOR STOOLS BRIGHT RED, & THAT SUSPENSION, IF SPILLED, WILL STAIN.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1030
For more Therapeutic Uses (Complete) data for PYRVINIUM (7 total), please visit the HSDB record page.
VET: ALTHOUGH EQUALLY EFFECTIVE, CHLORIDE FORM IS 4 TIMES AS TOXIC AS PAMOATE FORM. /CHLORIDE; PAMOATE/
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 501
A CASE OF ACCIDENTAL PARENTERAL INJECTION OF POVAN IS DESCRIBED.
SILVERMAN ET AL; A CASE OF ACCIDENTAL PARENTERAL INJECTION OF POVAN; TOXICOL APPL PHARMACOL 16 (3): 740 (1970)
Pyrvinium was once used in the treatment of pinworm infestations.
Pyrvinium is an anthelmintic agent which acts to kill pinworms.
Anthelmintics
Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)
P - Antiparasitic products, insecticides and repellents
P02 - Anthelmintics
P02C - Antinematodal agents
P02CX - Other antinematodals
P02CX01 - Pyrvinium
Absorption
Pyrvinium is not significantly absorbed from the gastrointestinal tract.
WHEN GIVEN BY ORAL ROUTE, PYRVINIUM PAMOATE IS NOT ABSORBED FROM GI TRACT TO ANY APPRECIABLE EXTENT. /PAMOATE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1030
Pyrvinium is believed to interfere with glucose uptake by pinworms. Pyrvinium is also thought to inhibit mitochondrial respiration complex 1 and suppress the unfolded protein response. It is also believed to supress the Wnt pathway by activating casein kinase 1. These properties have led to the investigation of pyrvinium's activity against cancers like intestinal polyposis.
INHIBITION OF OXYGEN UPTAKE OF ADULT LITOMOSOIDES IS EFFECTED BY...COMPD CONTAINING AMIDINIUM ION SYSTEM, IN WHICH A QUATERNARY NITROGEN IS SEPARATED FROM A TERTIARY NITROGEN BY RESONATING CARBON CHAIN OF ALTERNATING DOUBLE & SINGLE BONDS. THIS RESP INHIBITION IS ASSOC WITH COMPENSATORY INCR IN AEROBIC GLYCOLYSIS. /PAMOATE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1029
...ANTHELMINTIC ACTIVITY...IS ASSOC WITH INHIBITION OF RESP IN AEROBES, & INTERFERENCE WITH ABSORPTION OF EXOGENOUS GLUCOSE IN INTESTINAL HELMINTHS. SUCH INTERFERENCE MAY ACCOUNT FOR ANTHELMINTIC EFFECTS OF CYANINES IN TRICHURIASIS & IN OTHER INTESTINAL HELMINTHIASES. /PAMOATE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1030
ABOUT THIS PAGE
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PharmaCompass offers a list of Pyrvinum API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pyrvinum manufacturer or Pyrvinum supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pyrvinum manufacturer or Pyrvinum supplier.
PharmaCompass also assists you with knowing the Pyrvinum API Price utilized in the formulation of products. Pyrvinum API Price is not always fixed or binding as the Pyrvinum Price is obtained through a variety of data sources. The Pyrvinum Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Pyrvinum manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pyrvinum, including repackagers and relabelers. The FDA regulates Pyrvinum manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pyrvinum API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Pyrvinum supplier is an individual or a company that provides Pyrvinum active pharmaceutical ingredient (API) or Pyrvinum finished formulations upon request. The Pyrvinum suppliers may include Pyrvinum API manufacturers, exporters, distributors and traders.
Pyrvinum Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Pyrvinum GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pyrvinum GMP manufacturer or Pyrvinum GMP API supplier for your needs.
A Pyrvinum CoA (Certificate of Analysis) is a formal document that attests to Pyrvinum's compliance with Pyrvinum specifications and serves as a tool for batch-level quality control.
Pyrvinum CoA mostly includes findings from lab analyses of a specific batch. For each Pyrvinum CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Pyrvinum may be tested according to a variety of international standards, such as European Pharmacopoeia (Pyrvinum EP), Pyrvinum JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pyrvinum USP).
