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Chemistry

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Also known as: 1628730-49-3, Iw-1973, Praliciguat [inn], R1s0h458sa, 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]methyl]propan-2-ol, 2-propanol, 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-((2-fluorophenyl)methyl)-5-(3-isoxazolyl)-1h-pyrazol-3-yl)-4-pyrimidinyl)amino)methyl)-
Molecular Formula
C21H14F8N6O2
Molecular Weight
534.4  g/mol
InChI Key
CYSJNTQNMDWAJV-UHFFFAOYSA-N
FDA UNII
R1S0H458SA

Praliciguat
Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)).
1 2D Structure

Praliciguat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]methyl]propan-2-ol
2.1.2 InChI
InChI=1S/C21H14F8N6O2/c22-12-4-2-1-3-11(12)9-35-16(14-5-6-37-34-14)7-15(33-35)18-30-8-13(23)17(32-18)31-10-19(36,20(24,25)26)21(27,28)29/h1-8,36H,9-10H2,(H,30,31,32)
2.1.3 InChI Key
CYSJNTQNMDWAJV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)CN2C(=CC(=N2)C3=NC=C(C(=N3)NCC(C(F)(F)F)(C(F)(F)F)O)F)C4=NOC=C4)F
2.2 Other Identifiers
2.2.1 UNII
R1S0H458SA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1h-pyrazol-3-yl) Pyrimidin-4-yl)amino)methyl)propan-2-ol

2. Iw-1973

2.3.2 Depositor-Supplied Synonyms

1. 1628730-49-3

2. Iw-1973

3. Praliciguat [inn]

4. R1s0h458sa

5. 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]methyl]propan-2-ol

6. 2-propanol, 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-((2-fluorophenyl)methyl)-5-(3-isoxazolyl)-1h-pyrazol-3-yl)-4-pyrimidinyl)amino)methyl)-

7. 2-propanol, 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1h-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]-

8. Praliciguatum

9. Praliciguat (usan/inn)

10. Praliciguat [usan]

11. Unii-r1s0h458sa

12. Praliciguat [who-dd]

13. Gtpl9900

14. Chembl4297214

15. Schembl16082414

16. Chebi:142431

17. Bdbm321618

18. Dtxsid901101232

19. Ex-a5960

20. Iw1973

21. Us10183021, Compound I-324

22. Bp177758

23. Hy-109039

24. Cs-0031480

25. D11274

26. D87220

27. 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-((2-fluorophenyl)methyl)-5-(1,2-oxazol-3-yl)-1h-pyrazol-3-yl)pyrimidin-4-yl)amino)methyl)propan-2-ol

28. 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1h-pyrazol-3-yl) Pyrimidin-4-yl)amino)methyl)propan-2-ol

29. 1,1,1,3,3,3-hexafluoro-2-[({5-fluoro-2-[1-(2-fluorobenzyl)-5-(1,2-oxazol-3-yl)-1h-pyrazol-3-yl]pyrimidin-4-yl}amino)methyl]propan-2-ol

30. 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1h-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]-2-propanol

31. 1,1,1-trifluoro-3-[(5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1h-pyrazol-3-yl}pyrimidin-4-yl)amino]-2-(trifluoromethyl)propan-2-ol

2.4 Create Date
2014-11-10
3 Chemical and Physical Properties
Molecular Weight 534.4 g/mol
Molecular Formula C21H14F8N6O2
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count15
Rotatable Bond Count7
Exact Mass534.10504901 g/mol
Monoisotopic Mass534.10504901 g/mol
Topological Polar Surface Area102 Ų
Heavy Atom Count37
Formal Charge0
Complexity748
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Guanylyl Cyclase C Agonists

Compunds that bind to and activate GUANYLYL CYCLASE-C RECEPTORS. (See all compounds classified as Guanylyl Cyclase C Agonists.)


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ABOUT THIS PAGE

Looking for 1628730-49-3 / Praliciguat API manufacturers, exporters & distributors?

Praliciguat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Praliciguat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Praliciguat manufacturer or Praliciguat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Praliciguat manufacturer or Praliciguat supplier.

PharmaCompass also assists you with knowing the Praliciguat API Price utilized in the formulation of products. Praliciguat API Price is not always fixed or binding as the Praliciguat Price is obtained through a variety of data sources. The Praliciguat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Praliciguat

Synonyms

1628730-49-3, Iw-1973, Praliciguat [inn], R1s0h458sa, 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]methyl]propan-2-ol, 2-propanol, 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-((2-fluorophenyl)methyl)-5-(3-isoxazolyl)-1h-pyrazol-3-yl)-4-pyrimidinyl)amino)methyl)-

Cas Number

1628730-49-3

Unique Ingredient Identifier (UNII)

R1S0H458SA

About Praliciguat

Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)).

Praliciguat Manufacturers

A Praliciguat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Praliciguat, including repackagers and relabelers. The FDA regulates Praliciguat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Praliciguat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Praliciguat Suppliers

A Praliciguat supplier is an individual or a company that provides Praliciguat active pharmaceutical ingredient (API) or Praliciguat finished formulations upon request. The Praliciguat suppliers may include Praliciguat API manufacturers, exporters, distributors and traders.

Praliciguat GMP

Praliciguat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Praliciguat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Praliciguat GMP manufacturer or Praliciguat GMP API supplier for your needs.

Praliciguat CoA

A Praliciguat CoA (Certificate of Analysis) is a formal document that attests to Praliciguat's compliance with Praliciguat specifications and serves as a tool for batch-level quality control.

Praliciguat CoA mostly includes findings from lab analyses of a specific batch. For each Praliciguat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Praliciguat may be tested according to a variety of international standards, such as European Pharmacopoeia (Praliciguat EP), Praliciguat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Praliciguat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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