Piperazine, Hexahydrate

Synopsis, Chemistry

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Also known as: 142-63-2, Arthriticine, Piperazine, hexahydrate, Vermisol, Parid, Piperazine;hexahydrate

Molecular Formula

C₄H₂₂N₂O₆

Molecular Weight

194.23 g/mol

InChI Key

AVRVZRUEXIEGMP-UHFFFAOYSA-N

FDA UNII

P3M07B8U64

An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.

1 2D Structure

Piperazine, Hexahydrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

piperazine;hexahydrate

2.1.2 InChI

InChI=1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2

2.1.3 InChI Key

AVRVZRUEXIEGMP-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CNCCN1.O.O.O.O.O.O

2.2 Other Identifiers

2.2.1 UNII

P3M07B8U64

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1,4 Diazacyclohexane

2. 1,4 Piperazine

3. 1,4-diazacyclohexane

4. 1,4-piperazine

5. Piperazine

6. Piperazine Diacetate

7. Piperazine Dihydrochloride

8. Piperazine Hydrate

9. Piperazine Hydrobromide

10. Piperazine Hydrochloride

11. Piperazine Monohydrochloride

12. Piperazine Phosphate

13. Piperazine Phosphate (1:1)

14. Piperazine Phosphate Anhydrous

15. Piperazine Salt

16. Piperazine Sulfate

17. Piperazine Tartrate

18. Piperazine Tartrate (1:1), (r-(r*,r*))-isomer

19. Piperazine Tartrate, (r-(r*,r*))-isomer

20. Piperazinium Oleate

21. Pripsen

2.3.2 Depositor-Supplied Synonyms

1. 142-63-2

2. Arthriticine

3. Piperazine, Hexahydrate

4. Vermisol

5. Parid

6. Piperazine;hexahydrate

7. Piperazine (hexahydrate)

8. P3m07b8u64

9. Piperazinehexahydrate

10. Usaf A-3803

11. Mfcd00149389

12. Diethylenediamine Hexahydrate

13. Unii-p3m07b8u64

14. Ai3-26675

15. Vermyl (tn)

16. Hy-b0912a

17. Dtxsid50161918

18. 1,4-piperazine Hexahydrate

19. Piperazine Hexahydrate [ii]

20. Piperazine Hexahydrate [mi]

21. Piperazine Hydrate [mart.]

22. Piperazine, Hydrate (1:6)

23. Piperazine Hexahydrate [vandf]

24. Akos000121857

25. Cs-7631

26. Piperazine Hexahydrate [who-dd]

27. Ls-13032

28. Piperazine Hexahydrate, Analytical Standard

29. Ft-0689820

30. D08381

31. J-007675

32. Q3905511

33. Piperazine Hydrate, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date

2005-07-19

3 Chemical and Physical Properties

Molecular Formula	C₄H₂₂N₂O₆
Molecular Weight	194.23 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	0
Exact Mass	194.14778643 g/mol
Monoisotopic Mass	194.14778643 g/mol
Topological Polar Surface Area	30.1 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	26.5
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	7

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antinematodal Agents

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)