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Pimobendan

Pimobendan

Synopsis, Chemistry

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Also known as: 74150-27-9, Pimobendane, Acardi, Dl-pimobendan, Vetmedin, D-pimobendan

Molecular Formula

C₁₉H₁₈N₄O₂

Molecular Weight

334.4 g/mol

InChI Key

GLBJJMFZWDBELO-UHFFFAOYSA-N

FDA UNII

9HTU209Z0N

1 2D Structure

Pimobendan

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one

2.1.2 InChI

InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)

2.1.3 InChI Key

GLBJJMFZWDBELO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC

2.2 Other Identifiers

2.2.1 UNII

9HTU209Z0N

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazole-5-yl)-5-methyl-3(2h)-pyridazinone

2. Pimobendane

3. Ud Cg 115

4. Ud-cg 115

5. Ud-cg115

2.3.2 Depositor-Supplied Synonyms

1. 74150-27-9

2. Pimobendane

3. Acardi

4. Dl-pimobendan

5. Vetmedin

6. D-pimobendan

7. (-)-pimobendan

8. Pimobendan, (-)-

9. (+)-pimobendan

10. Pimobendanum

11. Ud-cg 115 Bs

12. Ud-cg 115

13. 118428-37-8

14. Pimobendan, (+)-

15. Pimobendan (vetmedin)

16. Ud-cg-115bs

17. Racemic Pimobendan

18. 118428-38-9

19. Udcg-115

20. 6-(2-(4-methoxyphenyl)-1h-benzo[d]imidazol-5-yl)-5-methyl-4,5-dihydropyridazin-3(2h)-one

21. Ud-cg-115

22. 3-[2-(4-methoxyphenyl)-3h-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1h-pyridazin-6-one

23. Brn 4207330

24. 34ap3bbp9t

25. Chembl24646

26. 613jxv89su

27. 9htu209z0n

28. Chebi:32003

29. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-, (+)-

30. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-, (-)-

31. L-pimobendan

32. Racemic Pinobendan

33. 6-(2-(4-methoxyphenyl)-1h-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2h)-one

34. 6-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2h)-one

35. Pimobendan [inn-spanish]

36. Pimobendane [inn-french]

37. Pimobendanum [inn-latin]

38. (+)-ud-cg 115bs

39. (-)-ud-cg 115bs

40. Ncgc00274063-01

41. Unii-34ap3bbp9t

42. Unii-613jxv89su

43. Unii-9htu209z0n

44. Pimobendan [usan:inn:ban]

45. Ud-cg115

46. 3-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1h-pyridazin-6-one

47. Acardi (tn)

48. Pimobendan - Vetmedin

49. Pimobendan [mi]

50. Pimobendan [inn]

51. Pimobendan [jan]

52. Pimobendan [usan]

53. Pimobendan [mart.]

54. (+)-4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-3(2h)-pyridazinone

55. (-)-4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-3(2h)-pyridazinone

56. 4,5-dihydro-6-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-5-methyl-3(2h)-pyridazinone

57. 6-(2-(4-methoxyphenyl)-4,5-dihydro-1h-benzimidazol-5-yl)-5-methyl-3(2h)-pyridazinone

58. Pimobendan [usp-rs]

59. Pimobendan [who-dd]

60. Schembl27623

61. Mls006010188

62. Pimobendan (jan/usan/inn)

63. Pimobendan [green Book]

64. Dtxsid8048280

65. Pimobendan [ep Impurity]

66. Pimobendan, >=98% (hplc)

67. Hms3655i03

68. Hms3884c21

69. Kuc109647n

70. Pimobendan [usp Monograph]

71. Bcp02958

72. Hy-b0204

73. Ac-689

74. Bdbm50282617

75. Mfcd00761648

76. S1550

77. Akos015851937

78. Akos015967705

79. Ccg-267853

80. Db11450

81. Ks-1280

82. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-

83. 6-[2-(4-methoxy-phenyl)-1h-benzoimidazol-5-yl]-5-methyl-4,5-dihydro-2h-pyridazin-3-one

84. Ksc-210-009

85. Pimobendan [ema Epar Veterinary]

86. Fortekor Plus Component Pimobendan

87. Ncgc00274063-04

88. Ncgc00274063-05

89. 118428-36-7

90. Pimobendan 100 Microg/ml In Acetonitrile

91. Smr002530068

92. Bcp0726000255

93. Ft-0630830

94. P2779

95. Pimobendan Component Of Fortekor Plus

96. Sw219717-1

97. D01133

98. Ab01274800-01

99. Ab01274800_02

100. 150p279

101. Q414351

102. J-517984

103. Pimobendan, United States Pharmacopeia (usp) Reference Standard

104. 4,5-dihydro-6-[2-(4-methoxy-phenyl)-1h-benzimidazol-5-yl]-5-methyl-3 (2h)-pyridazinone

105. Pimobendan For System Suitability, European Pharmacopoeia (ep) Reference Standard

106. (+/-)-4,5-dihydro-6-(2-(p-methoxyphenyl)-5-benzimidazolyl)-5-methyl-3(2h)-pyridazinone

107. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-, (+/-)-

108. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-6-yl)-5-methyl-

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₈N₄O₂
Molecular Weight	334.4 g/mol
XLogP3	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	334.14297583 g/mol
Monoisotopic Mass	334.14297583 g/mol
Topological Polar Surface Area	79.4 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	530
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Phosphodiesterase Inhibitors

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)

Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)