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Pholedrine

Pholedrine

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Also known as: Pulsotyl, Veritol, Pressitan, 370-14-9, Paredrinol, Sympropamin

Molecular Formula

C₁₀H₁₅NO

Molecular Weight

165.23 g/mol

InChI Key

SBUQZKJEOOQSBV-UHFFFAOYSA-N

FDA UNII

AY28O44JGD

1 2D Structure

Pholedrine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[2-(methylamino)propyl]phenol

2.1.2 InChI

InChI=1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3

2.1.3 InChI Key

SBUQZKJEOOQSBV-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(CC1=CC=C(C=C1)O)NC

2.2 Other Identifiers

2.2.1 UNII

AY28O44JGD

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-hydroxy-n-methylamphetamine

2. 4-hydroxymethamphetamine

3. P-hydroxymethamphetamine

4. Pholedrin Liquidum

5. Pholedrin-longo-isis

6. Pholedrine Sulfate (1:1)

7. Pholedrine Sulfate (2:1)

8. Pholedrine, Sulfate (1:1), (+-)-isomer

9. Pholedrine, Sulfate (2:1), (+-)-isomer

10. Pulsotyl

11. Veritol

2.3.2 Depositor-Supplied Synonyms

1. Pulsotyl

2. Veritol

3. Pressitan

4. 370-14-9

5. Paredrinol

6. Sympropamin

7. Foledrin

8. Isodrinum

9. Pholetone

10. Stimatone

11. Syncordan

12. Terapinyl

13. Varitol

14. Veritain

15. Epifen

16. 4-[2-(methylamino)propyl]phenol

17. Knoll H75

18. 4-hydroxymethamphetamine

19. Promethin

20. Prometin

21. 4-(2-(methylamino)propyl)phenol

22. P-hydroxymethamphetamine

23. N-methylparedrine

24. Racemic Pholedrine

25. 4-hydroxy-n-methylamphetamine

26. Pholedrinum

27. P-hydroxy-n-methylbenzedrine

28. P-(2-methylaminopropyl)phenol

29. (+/-)-pholedrine

30. Isodrin (sympathomimetic)

31. 1-(p-hydroxyphenyl)-2-methylaminopropane

32. Oh-ma

33. P-hydroxy-n-methylamphetamine

34. P-hydroxy-n,alpha-dimethylphenethylamine

35. Beta-(p-hydroxyphenyl)isopropylmethylamine

36. Phenethylamine, P-hydroxy-n,alpha-dimethyl-

37. Phenol, P-(2-(methylamino)propyl)-

38. Alpha-(p-oxyphenyl)-beta-methyl Aminopropane

39. 1-(p-oxyphenyl)-2-methylaminopropan

40. Knoll-h75

41. Ay28o44jgd

42. Pholedrine (inn)

43. Phenol, 4-(2-(methylamino)propyl)-

44. Phenol, 4-[2-(methylamino)propyl]-

45. P-hydroxy-n,.alpha.-dimethylphenethylamine

46. Pholedrine [inn]

47. .beta.-(p-hydroxyphenyl)isopropylmethylamine

48. .alpha.-(p-hydroxyphenyl)-.beta.-methylaminopropane

49. (+/-)-1-(4-hydroxyphenyl)-n-methyl-2-aminopropane

50. Foledrinio

51. Rac Pholedrine

52. Phenol, P-[2-(methylamino)propyl]-

53. Pholedrinum [inn-latin]

54. Foledrinio [inn-spanish]

55. Pholedrine [inn:ban:dcf]

56. Einecs 206-725-0

57. Unii-ay28o44jgd

58. Pholedrin

59. P-[2-(methylamino)propyl]phenol

60. 1-(p-oxyphenyl)-2-methylaminopropan [german]

61. Alpha-(p-hydroxyphenyl)-beta-methylaminopropane

62. Beta(p-oxy-phenyl)isopropylmethylamin [german]

63. Beta(p-oxy-phenyl)isopropylmethylamin

64. Pholedrine [mi]

65. Pholedrine [who-dd]

66. Schembl119262

67. Chembl2008672

68. Dtxsid70861908

69. P-[(2-methylamino)propyl]phenol

70. Chebi:134798

71. Isodrin (sympathomimetic Compound)

72. P-[2-(methylamino)propyl]-phenol

73. P-hydroxy-n,a-dimethylphenethylamine

74. Akos005216720

75. Akos017390993

76. (+)-4-[2-(methylamino)propyl]phenol

77. (?)-4-[2-(methylamino)propyl]phenol

78. Nci60_042163

79. P-hydroxymethamphetamine, (+/-)-

80. Db-049052

81. Alpha-(p-hydroxyphenyl-beta-methylaminopropane

82. D08370

83. Phenethylamine, P-hydroxy-n,.alpha.-dimethyl-

84. P-hydroxymethamphetamine, 1.0 Mg/ml In Methanol

85. .alpha.-(p-oxyphenyl)-.beta.-methyl Aminopropane

86. Sr-01000944930

87. Q7187065

88. Sr-01000944930-1

89. P-hydroxymethamphetamine, Analytical Standard, For Drug Analysis

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₅NO
Molecular Weight	165.23 g/mol
XLogP3	1.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	165.115364102 g/mol
Monoisotopic Mass	165.115364102 g/mol
Topological Polar Surface Area	32.3 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	119
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

4.2 Metabolism/Metabolites

HO-MA is a known human metabolite of p-Methoxymethamphetamine, R-(-)-.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560