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Phentermine Hydrochloride
Also known as: 1197-21-3, Phentermine hcl, Fastin, Oby-trim, Phenteral, Tora
Molecular Formula
C10H16ClN
Molecular Weight
185.69  g/mol
InChI Key
NCAIGTHBQTXTLR-UHFFFAOYSA-N
FDA UNII
0K2I505OTV

A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
1 2D Structure

Phentermine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-methyl-1-phenylpropan-2-amine;hydrochloride
2.1.2 InChI
InChI=1S/C10H15N.ClH/c1-10(2,11)8-9-6-4-3-5-7-9;/h3-7H,8,11H2,1-2H3;1H
2.1.3 InChI Key
NCAIGTHBQTXTLR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(CC1=CC=CC=C1)N.Cl
2.2 Other Identifiers
2.2.1 UNII
0K2I505OTV
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Adipex P

2. Adipex-p

3. Adipexp

4. Duromine

5. Hydrochloride, Phentermine

6. Ionamine

7. Phentermine

2.3.2 Depositor-Supplied Synonyms

1. 1197-21-3

2. Phentermine Hcl

3. Fastin

4. Oby-trim

5. Phenteral

6. Tora

7. Ona-mast

8. Phentermyl Wyncaps

9. Obestin-30

10. 2-methyl-1-phenylpropan-2-amine Hydrochloride

11. Suprenza

12. Wilpo

13. Ona-mast Hydrochloride

14. Adipex-p

15. Ionamin

16. Zantryl

17. Alpha,alpha-dimethylphenethylamine Hydrochloride

18. Phentermine Hydrochloride [usp]

19. Mg 18370

20. S 58

21. 1,1-dimethyl-2-phenylethylamine Hydrochloride

22. 1-phenyl-2-methyl-2-aminopropane Hydrochloride

23. Nsc-44090

24. Phentermine Hydrochloride Civ

25. Phenyl-t-butylamine Hydrochloride

26. 0k2i505otv

27. Duromine

28. Dea No. 1640

29. 2-methyl-1-phenylpropan-2-amine;hydrochloride

30. Benzeneethanamine, Alpha,alpha-dimethyl, Hydrochloride

31. .alpha.,.alpha.-dimethylphenethylamine Hydrochloride

32. Wilpo (van)

33. Phentermine Hydrochloride (usp)

34. Chebi:50506

35. Alpha-methylamphetamine Hydrochloride

36. Einecs 214-821-9

37. Nsc 44090

38. Unii-0k2i505otv

39. Lomaira

40. Fastin (tn)

41. Adipex-p (tn)

42. Phenteramine Hydrochloride

43. Schembl41585

44. Mls003882563

45. Phenethylamine, Alpha,alpha-dimethyl-, Hydrochloride

46. Benzeneethanamine, Alpha,alpha-dimethyl-, Hydrochloride

47. Chembl1200912

48. Dtxsid20152550

49. Wln: Zx1&1&1r &gh

50. Bcp23776

51. Nsc44090

52. Phentermine Hydrochloride [mi]

53. Akos015891196

54. .alpha.-methylamphetamine Hydrochloride

55. Ccg-221139

56. Phentermine Hydrochloride [mart.]

57. Phentermine Hydrochloride [vandf]

58. Mg 18570

59. Phentermine Hydrochloride [usp-rs]

60. Phentermine Hydrochloride [who-dd]

61. Smr000058739

62. Phentermine Hydrochloride, >=98% (hplc)

63. 2-methyl-1-phenyl-2-propanamine Hydrochloride

64. 2-amino-2-methyl-1-phenylpropane Hydrochloride

65. D05459

66. Phentermine Hcl; Adipex P; Adipex-p; Adipexp

67. Phentermine Hydrochloride [orange Book]

68. Benzeneethanamine,.alpha.-dimethyl, Hydrochloride

69. Phentermine Hydrochloride [usp Monograph]

70. Qsymia Component Phentermine Hydrochloride

71. Phentermine Hydrochloride Component Of Qsymia

72. Q19885635

73. Benzeneethanamine, .alpha.,.alpha.-dimethyl-, Hydroch

74. Phentermine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 185.69 g/mol
Molecular Formula C10H16ClN
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass185.0971272 g/mol
Monoisotopic Mass185.0971272 g/mol
Topological Polar Surface Area26 Ų
Heavy Atom Count12
Formal Charge0
Complexity112
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NamePhentermine hydrochloride
PubMed HealthPhentermine (By mouth)
Drug ClassesAppetite Suppressant, Centrally Acting
Drug LabelPhentermine hydrochloride USP has the chemical name of , -Dimethylphenethylamine hydrochloride. The structural formula is as follows:C10H15NHClM.W. 185.7Phentermine hydrochlor...
Active IngredientPhentermine hydrochloride
Dosage FormTablet; Capsule
RouteOral
Strength37.5mg; 30mg; 15mg
Market StatusPrescription
CompanyVintage Pharms; Aurolife Pharma; Ken Lifescience; Mirror Pharms; Sun Pharm Inds; Sandoz; Invagen Pharms; Lannett Holdings; Lannett; Mutual Pharm; Mikah Pharma; Kvk Tech; Elite Labs; Barr

2 of 4  
Drug NameSuprenza
Drug LabelSuprenza is an orally disintegrating tablet (ODT) of phentermine hydrochloride, USP. Phentermine hydrochloride is a sympathomimetic amine anorectic. Its chemical name is ,,-dimethylphenethylamine hydrochloride. The structural formula is as follow...
Active IngredientPhentermine hydrochloride
Dosage FormTablet, orally disintegrating
RouteOral
Strength37.5mg; 30mg; 15mg
Market StatusPrescription
CompanyCitius Pharms

3 of 4  
Drug NamePhentermine hydrochloride
PubMed HealthPhentermine (By mouth)
Drug ClassesAppetite Suppressant, Centrally Acting
Drug LabelPhentermine hydrochloride USP has the chemical name of , -Dimethylphenethylamine hydrochloride. The structural formula is as follows:C10H15NHClM.W. 185.7Phentermine hydrochlor...
Active IngredientPhentermine hydrochloride
Dosage FormTablet; Capsule
RouteOral
Strength37.5mg; 30mg; 15mg
Market StatusPrescription
CompanyVintage Pharms; Aurolife Pharma; Ken Lifescience; Mirror Pharms; Sun Pharm Inds; Sandoz; Invagen Pharms; Lannett Holdings; Lannett; Mutual Pharm; Mikah Pharma; Kvk Tech; Elite Labs; Barr

4 of 4  
Drug NameSuprenza
Drug LabelSuprenza is an orally disintegrating tablet (ODT) of phentermine hydrochloride, USP. Phentermine hydrochloride is a sympathomimetic amine anorectic. Its chemical name is ,,-dimethylphenethylamine hydrochloride. The structural formula is as follow...
Active IngredientPhentermine hydrochloride
Dosage FormTablet, orally disintegrating
RouteOral
Strength37.5mg; 30mg; 15mg
Market StatusPrescription
CompanyCitius Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic Agents

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)


Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Increased Sympathetic Activity [PE]; Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]
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  • TABLET;ORAL - 37.5MG
  • CAPSULE;ORAL - 30MG
  • CAPSULE;ORAL - 15MG
  • CAPSULE;ORAL - 30MG
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