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    Chemistry

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    Also known as: 380917-97-5, Fycompa, E2007, Er-155055-90, E-2007, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
    Molecular Formula
    C23H15N3O
    Molecular Weight
    349.4  g/mol
    InChI Key
    PRMWGUBFXWROHD-UHFFFAOYSA-N
    FDA UNII
    H821664NPK
    Perampanel
    Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity. Although the mechanism of action through which perampanel exerts its antiepileptic effect has not been fully elucidated, this agent antagonizes the AMPA subtype of the excitatory glutamate receptor found on postsynaptic neurons in the central nervous system (CNS). This antagonistic action prevents AMPA receptor activation by glutamate and results in the inhibition of neuronal excitation, repetitive neuronal firing, and the stabilization of hyper-excited neural membranes. Glutamate, the primary excitatory neurotransmitter in the CNS, plays an important role in various neurological disorders caused by neuronal hyperexcitation.
    Perampanel is a Noncompetitive AMPA Glutamate Receptor Antagonist. The mechanism of action of perampanel is as an AMPA Receptor Antagonist, and UGT2B7 Inhibitor, and UGT1A9 Inhibitor, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
    1 2D Structure

    Perampanel

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile
    2.1.2 InChI
    InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
    2.1.3 InChI Key
    PRMWGUBFXWROHD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
    2.2 Other Identifiers
    2.2.1 UNII
    H821664NPK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

    2. E-2007

    3. E2007

    4. Er-155055-90

    5. Fycompa

    6. Perampanel Hydrate

    7. Perampanel Hydrate (4:3)

    2.3.2 Depositor-Supplied Synonyms

    1. 380917-97-5

    2. Fycompa

    3. E2007

    4. Er-155055-90

    5. E-2007

    6. 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

    7. E 2007

    8. Perampanel (usan)

    9. Chebi:71013

    10. Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-

    11. 2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile

    12. H821664npk

    13. Perampanel [usan]

    14. Fycompa (tn)

    15. 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'h)-one

    16. 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile

    17. 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile

    18. Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl(2,3'-bipyridin)-5'-yl)-

    19. Perampanel [usan:inn]

    20. Perampanelum

    21. Unii-h821664npk

    22. Perampanel(e2007

    23. Perampanel [mi]

    24. Perampanel [inn]

    25. Perampanel [vandf]

    26. Perampanel [who-dd]

    27. Schembl194370

    28. Gtpl7050

    29. Chembl1214124

    30. Perampanel [orange Book]

    31. Dtxsid80191501

    32. Bcp06505

    33. Ex-a2128

    34. Bdbm50184410

    35. Zinc30691797

    36. Akos016340421

    37. Ch-0056

    38. Cs-1160

    39. Db08883

    40. Sb16816

    41. Ncgc00378863-02

    42. Ac-27375

    43. Am806751

    44. Hy-14745

    45. D08964

    46. Q868658

    47. 2-(6-oxo-1-phenyl-1,6-dihydro-[2,3-bipyridin]-5-yl)benzonitrile

    48. 3-(2-cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one

    49. 1174302-51-2

    50. 6zp

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 349.4 g/mol
    Molecular Formula C23H15N3O
    XLogP33.4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass349.121512110 g/mol
    Monoisotopic Mass349.121512110 g/mol
    Topological Polar Surface Area57 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity664
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFycompa
    PubMed HealthPerampanel (By mouth)
    Drug ClassesAnticonvulsant, Central Nervous System Agent
    Drug LabelFYCOMPA tablets contain perampanel, a non-competitive AMPA receptor antagonist. Perampanel is described chemically as 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate (4:3).The molecular formula is C23H15N3O 3/4H2O,...
    Active IngredientPerampanel
    Dosage FormTablet
    RouteOral
    Strength8mg; 4mg; 12mg; 6mg; 2mg; 10mg
    Market StatusPrescription
    CompanyEisai

    2 of 2  
    Drug NameFycompa
    PubMed HealthPerampanel (By mouth)
    Drug ClassesAnticonvulsant, Central Nervous System Agent
    Drug LabelFYCOMPA tablets contain perampanel, a non-competitive AMPA receptor antagonist. Perampanel is described chemically as 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate (4:3).The molecular formula is C23H15N3O 3/4H2O,...
    Active IngredientPerampanel
    Dosage FormTablet
    RouteOral
    Strength8mg; 4mg; 12mg; 6mg; 2mg; 10mg
    Market StatusPrescription
    CompanyEisai

    4.2 Drug Indication

    Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.

    FDA Label

    Fycompa is indicated for the adjunctive treatment of partial-onset seizures with or without secondarily generalised seizures in adult and adolescent patients from 12 years of age with epilepsy.

    Fycompa is indicated for the adjunctive treatment of primary generalised tonic-clonic seizures in adult and adolescent patients from 12 years of age with idiopathic generalised epilepsy.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Perampanel is involved in inhibiting neuronal excitation in the central nervous system leading to such effects as decreased pyschomotor performance.

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    PERAMPANEL
    5.2.2 FDA UNII
    H821664NPK
    5.2.3 Pharmacological Classes
    Cytochrome P450 2C8 Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; Noncompetitive AMPA Glutamate Receptor Antagonist [EPC]; UGT1A9 Inhibitors [MoA]; UGT2B7 Inhibitors [MoA]; AMPA Receptor Antagonists [MoA]
    5.3 ATC Code

    N03AX22

    N03AX22

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N03 - Antiepileptics

    N03A - Antiepileptics

    N03AX - Other antiepileptics

    N03AX22 - Perampanel

    5.4 Absorption, Distribution and Excretion

    Absorption

    After oral adminitration, perampanel is absorbed rapidly and completely.

    Route of Elimination

    Perampanel is eliminated mostely in the feces (48%) and to a lesser exten in the urine (22%).

    Volume of Distribution

    The volume of distribution of perampanel was not quantified.

    Clearance

    In healthy patients, perampanel has a clearance of about 12 mL/min.

    5.5 Metabolism/Metabolites

    Perampanel is highly metabolized by CYP3A4 and/or CYP3A5 primary oxidation and by sequential glucuronidation.

    5.6 Biological Half-Life

    Perampanel has a long elmination half-life of about 105 hours.

    5.7 Mechanism of Action

    The exact mechanism of action of perampanel in seizures is not yet determined, but it is known that perampanel decreases neuronal excitation by non-competitive ihibition of the AMPA receptor.

    API Reference Price

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    21-Feb-2022
    19-Dec-2025
    KGS
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    Drugs in Development

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    Bioequivalence Assessment Between Two Perampanel Oral Suspension Formulations

    Details:

    Lepsiramp is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.


    Lead Product(s): Lepsiramp,Perampanel

    Therapeutic Area: Undisclosed Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Undisclosed

    Sponsor: Advanced Research Network | Global Napi Pharmaceuticals for Global Advanced Pharmaceuticals

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable May 14, 2025

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    Aya Mohammed Abdel Magid Abdel Hamid

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    Aya Mohammed Abdel Magid Abdel Hamid

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    Lead Product(s) : Lepsiramp,Perampanel

    Therapeutic Area : Undisclosed

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Advanced Research Network | Global Napi Pharmaceuticals for Global Advanced Pharmaceuticals

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Bioequivalence Assessment Between Two Perampanel Oral Suspension Formulations

    Details : Lepsiramp is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

    Product Name : Undisclosed

    Product Type : Undisclosed

    Upfront Cash : Inapplicable

    May 14, 2025

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    Stock Recap
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    Bioequivalence Study of Perampanel Tablets 12 mg

    Details:

    Perampanel is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Epilepsy.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 10, 2024

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    02

    Humanis

    Turkey
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    Not Confirmed

    Humanis

    Turkey
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    Not Confirmed
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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Bioequivalence Study of Perampanel Tablets 12 mg

    Details : Perampanel is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Epilepsy.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    June 10, 2024

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    Bioequivalence Study of Perampanel Tablets 10 mg

    Details:

    Perampanel is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Epilepsy.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 10, 2024

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    03

    Humanis

    Turkey
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    Turkey
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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Bioequivalence Study of Perampanel Tablets 10 mg

    Details : Perampanel is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Epilepsy.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    June 10, 2024

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    Fycompa® Approved in China for Primary Generalized Tonic-clonic Seizures

    Details:

    Fycompa is a selective, non-competitive AMPA glutamate receptor antagonist indicated for treating partial-onset seizures and primary generalized tonic-clonic seizures in patients aged 12 & older.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Fycompa

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable May 13, 2024

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    04

    Eisai

    Japan
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    Eisai

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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Fycompa® Approved in China for Primary Generalized Tonic-clonic Seizures

    Details : Fycompa is a selective, non-competitive AMPA glutamate receptor antagonist indicated for treating partial-onset seizures and primary generalized tonic-clonic seizures in patients aged 12 & older.

    Product Name : Fycompa

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    May 13, 2024

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    Eisai's Antiepileptic Drug Fycompa Injection Formulation Launches in Japan

    Details:

    Fycompa (perampanel) is a selective, non-competitive AMPA glutamate receptor antagonist indicated for treating partial-onset and primary generalized tonic-clonic seizures in patients aged 12 & older.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Fycompa

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable April 18, 2024

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    05

    Eisai

    Japan
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    Eisai

    Japan
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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Eisai's Antiepileptic Drug Fycompa Injection Formulation Launches in Japan

    Details : Fycompa (perampanel) is a selective, non-competitive AMPA glutamate receptor antagonist indicated for treating partial-onset and primary generalized tonic-clonic seizures in patients aged 12 & older.

    Product Name : Fycompa

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    April 18, 2024

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    Antiepileptic Drug Fycompa® Injection Formulation Approved in Japan

    Details:

    Fycompa (perampanel) is a selective, non-competitive AMPA glutamate receptor antagonist indicated for treating partial-onset and primary generalized tonic-clonic seizures in patients aged 12 & older.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Fycompa

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable January 18, 2024

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    06

    Eisai

    Japan
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    Eisai

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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Antiepileptic Drug Fycompa® Injection Formulation Approved in Japan

    Details : Fycompa (perampanel) is a selective, non-competitive AMPA glutamate receptor antagonist indicated for treating partial-onset and primary generalized tonic-clonic seizures in patients aged 12 & older.

    Product Name : Fycompa

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    January 18, 2024

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    Akums gets DCGI Approval for Perampanel Oral Suspension

    Details:

    Perampanel oral suspension is first-in-class anti-epileptic agent, With epileptic seizures being mediated by neurotransmitter glutamate, agent is highly selective, noncompetitive AMPA receptor antagonist that reduces neuronal hyperexcitation associated with seizures.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Fycompa-Generic

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 27, 2023

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    07

    Akums Lifesciences

    India
    arrow
    VMX
    Not Confirmed

    Akums Lifesciences

    India
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    VMX
    Not Confirmed
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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Akums gets DCGI Approval for Perampanel Oral Suspension

    Details : Perampanel oral suspension is first-in-class anti-epileptic agent, With epileptic seizures being mediated by neurotransmitter glutamate, agent is highly selective, noncompetitive AMPA receptor antagonist that reduces neuronal hyperexcitation associated w...

    Product Name : Fycompa-Generic

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    June 27, 2023

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    The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

    Details:

    Perampanel is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Depressive Disorder.


    Lead Product(s): Perampanel,Ketamine Hydrochloride

    Therapeutic Area: Psychiatry/Psychology Brand Name: Undisclosed

    Study Phase: Phase IIProduct Type: Miscellaneous

    Sponsor: American Foundation for Suicide Prevention | National Center for PTSD | VA Connecticut Healthcare System

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 27, 2023

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    08

    Yale University

    Country
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    Yale University

    Country
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    Lead Product(s) : Perampanel,Ketamine Hydrochloride

    Therapeutic Area : Psychiatry/Psychology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : American Foundation for Suicide Prevention | National Center for PTSD | VA Connecticut Healthcare System

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

    Details : Perampanel is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Depressive Disorder.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    March 27, 2023

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    Catalyst Pharmaceuticals Completes the Acquisition of U.S. Rights to FYCOMPA® (Perampanel) CIII

    Details:

    The completion of the acquisition, strengthens the company's Commercial Portfolio with the First and Only AMPA Receptor Antagonist Marketed Product for Epilepsy. Fycompa (perampanel), an oral medication, is a selective non-competitive AMPA receptor antagonist.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Fycompa

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Catalyst Pharmaceuticals

    Deal Size: Undisclosed Upfront Cash: $160.0 million

    Deal Type: Acquisition January 25, 2023

    blank

    09

    Eisai

    Japan
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    Eisai

    Japan
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    VMX
    Not Confirmed
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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Catalyst Pharmaceuticals

    Deal Size : Undisclosed

    Deal Type : Acquisition

    DEALS_DEV arrow-down

    Catalyst Pharmaceuticals Completes the Acquisition of U.S. Rights to FYCOMPA® (Perampanel) CIII

    Details : The completion of the acquisition, strengthens the company's Commercial Portfolio with the First and Only AMPA Receptor Antagonist Marketed Product for Epilepsy. Fycompa (perampanel), an oral medication, is a selective non-competitive AMPA receptor antag...

    Product Name : Fycompa

    Product Type : Miscellaneous

    Upfront Cash : $160.0 million

    January 25, 2023

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    Eisai to Divest Rights for Anti-Epileptic Drug Fycompa® (perampanel) CIII In United States to Catalyst Pharmaceuticals

    Details:

    Fycompa (perampanel) is a non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.


    Lead Product(s): Perampanel,Inapplicable

    Therapeutic Area: Neurology Brand Name: Fycompa

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Catalyst Pharmaceuticals

    Deal Size: Undisclosed Upfront Cash: $160.0 million

    Deal Type: Divestment December 20, 2022

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    10

    Eisai

    Japan
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    Eisai

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    Lead Product(s) : Perampanel,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Catalyst Pharmaceuticals

    Deal Size : Undisclosed

    Deal Type : Divestment

    DEALS_DEV arrow-down

    Eisai to Divest Rights for Anti-Epileptic Drug Fycompa® (perampanel) CIII In United States to Cat...

    Details : Fycompa (perampanel) is a non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with ...

    Product Name : Fycompa

    Product Type : Miscellaneous

    Upfront Cash : $160.0 million

    December 20, 2022

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    MSN’s Receives First Generic Approval for Perampanel in US
    MSN’s Receives First Generic Approval for Perampanel in US

    11 Jul 2025

    // FDA

    https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=218152

    FDA
    11 Jul 2025
    Share Share
    MSN Lab`s Generics Perampanel Receive Tentative Approval in US
    MSN Lab`s Generics Perampanel Receive Tentative Approval in US

    08 Jan 2025

    // FDA

    https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218178

    FDA
    08 Jan 2025
    Share Share
    MSN Lab`s Generics Perampanel Receives Tentative Approval in US
    MSN Lab`s Generics Perampanel Receives Tentative Approval in US

    16 Dec 2024

    // FDA

    https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218152

    FDA
    16 Dec 2024
    Share Share
    Teva Pharms's Generic Perampanel Receives Tentative Approval in US
    Teva Pharms's Generic Perampanel Receives Tentative Approval in US

    04 Jun 2024

    // FDA

    https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=209801

    FDA
    04 Jun 2024
    Share Share
    Eisai's antiepileptic drug Fycompa injection formulation launches in Japan
    Eisai's antiepileptic drug Fycompa injection formulation launches in Japan

    18 Apr 2024

    // BIOSPECTRUM ASIA

    https://www.biospectrumasia.com/news/25/24098/eisais-antiepileptic-drug-fycompa-injection-formulation-launches-in-japan.html

    BIOSPECTRUM ASIA
    18 Apr 2024
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    Ligand Partner Eisai Receives Approval for Injection Formulation of Fycompa
    Ligand Partner Eisai Receives Approval for Injection Formulation of Fycompa

    22 Feb 2024

    // BUSINESSWIRE

    https://www.businesswire.com/news/home/20240222424618/en

    BUSINESSWIRE
    22 Feb 2024
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    Russia-big.png
    Perampanel (2 kg) API needed in Russia [ENA23015]
    A Russian pharmaceutical company that focuses on the production and development of antiseptic and disinfecting drugs is looking for suppliers of Perampanel (2 kg) API for both development & commercial purposes. The suppliers must support this enquiry with DMF & CoA.
    21 May 2025

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    21 May 2025

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    21 May 2025

    Egypt.png
    Perampanel API needed in Egypt [ENA15755]
    A company that focuses on the development and manufacturing of OSDs, semi-solids & oral liquids is looking for suppliers of Perampanel API for development purposes. The suppliers must support this enquiry with GMP & CoA.
    07 Dec 2022

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    07 Dec 2022

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    Reply Comment (11)

    07 Dec 2022

    United_States_of_America.png
    Various APIs needed in the United States [ENA13744]
    A pharmaceutical company that specializes in development & manufacturing of generic finished formulations is looking for suppliers of Various APIs for development purpose. The suppliers must support this enquiry with DMF & CoA. 1. Perampanel API 2. Brivaracetam API
    25 May 2022

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    25 May 2022

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    Reply Comment (8)

    25 May 2022

    Russia-big.png
    Various APIs needed in Russia [ENA11828]
    A company that deals in the manufacturing & distribution of rare and orphan drugs is looking for suppliers of Various APIs for commercial purpose. 1. Perampanel API 2. Amantadine API 3. Tafamidis (0.1 kg) API
    09 Nov 2021

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    09 Nov 2021

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    Reply Comment (9)

    09 Nov 2021

    india-flag.png
    Perampanel (3 kg) API needed in India [ENA10571]
    One of the world leaders in developing and manufacturing a wide range of brands/ non-brands generics including Oncology and ARV drugs is looking for suppliers of Perampanel (3 kg) API for development purposes. The suppliers must support this enquiry with CoA.
    04 Jun 2021

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    04 Jun 2021

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    Reply Comment (11)

    04 Jun 2021

    Nepal-1536751262.png
    Various APIs needed in Nepal [ENA10138]
    Rex Trading Corporation, a trading company based in Bangladesh is looking for a supplier of Various APIs. The suppliers must support this enquiry with CoA and GMP. Interested suppliers can contact them via email: samrexbd@gmail.com. 1. BP/ USP Grade Perampanel (MOQ) API 2. BP/ USP Grade Alcaftadine (MOQ) API 3. BP/ USP Grade Midodrine HCl (10 kg) API 4. BP/ USP Grade Fenticonazole Nitrate (10 kg) API
    07 Apr 2021

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    07 Apr 2021

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    Reply Comment (3)

    07 Apr 2021

    United_States_of_America.png
    Perampanel (100 g - 1 kg) API needed in the US [ENA08634]
    A large research-based organization based in the United States is looking for suppliers of Perampanel (100 g - 1 kg) API for clinical trials. The suppliers must support this enquiry with USFDA & GMP.
    24 Sep 2020

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    24 Sep 2020

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    Reply Comment (9)

    24 Sep 2020

    Bangladesh.png
    Various APIs needed in Bangladesh [ENA08029]
    Pharmalink Trade Corporation, an Indentor company based in Bangladesh is looking for suppliers of Various APIs for the Bangladesh market. The required quantity is MOQ for each. The suppliers must support this enquiry with CoA. Interested suppliers can contact them via their e-mail: pharmalinktrade@hotmail.com. 1. USP Grade Ubrogepant 2. USP Grade Rimegepant 3. Mucopolysaccharide Polysulphate 4. Cangrelor Lyophilized Powder 5. Filgotinib 6. Lemborexant 7. USP Grade Ezetimibe 8. Ospemifene 9. Lumateperone 10. Perampanel 11. Fostamatinib Disodium Hexahydrate 12. Trientine HCl 13. Teicoplanin Lyophilized Powder 14. Trifarotene
    24 Jul 2020

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    24 Jul 2020

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    Reply Comment (5)

    24 Jul 2020

    india-flag.png
    Perampanel (100 g) API needed in India [ENA08021]
    A global CRDO providing drug discovery and development services to the biopharma industry is looking for suppliers of Novel Crystalline Form-M Perampanel (100 g) API. The supplier must support this enquiry with USDMF. The final market is the US.
    23 Jul 2020

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    23 Jul 2020

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    Reply Comment (1)

    23 Jul 2020

    korearepublicofnew.png
    Perampanel, Metoclopramide & other APIs needed in Korea [ENA05440]
    Rihu Healthcare, a leading value-added and multifunctional trader and distributor of pharmaceutical products, chemicals and functional health industries in Korea is looking for suppliers of below mentioned APIs. The supplier must support this enquiry with CoA and GMP. Interested suppliers can contact them via Email: justin.lim@rihuhealthcare.com. 1. Perampanel 2. Metoclopramide base 3. Brivaracetam 4. Lifitegrast 5. Cimetidine 6. Choline Chloride 7. Isolated Soy protein 8. Sodium Caseinate 9. Soybean Phospholipids 10. Calcium caseinate 11. Corn Oil
    15 Oct 2019

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    15 Oct 2019

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    15 Oct 2019

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    01

    CATALYST PHARMS

    PERAMPANEL

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    CATALYST PHARMS

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    ABOUT THIS PAGE

    Looking for 380917-97-5 / Perampanel API manufacturers, exporters & distributors?

    Perampanel manufacturers, exporters & distributors 1

    48

    PharmaCompass offers a list of Perampanel API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Perampanel manufacturer or Perampanel supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Perampanel manufacturer or Perampanel supplier.

    PharmaCompass also assists you with knowing the Perampanel API Price utilized in the formulation of products. Perampanel API Price is not always fixed or binding as the Perampanel Price is obtained through a variety of data sources. The Perampanel Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Perampanel

    Synonyms

    380917-97-5, Fycompa, E2007, Er-155055-90, E-2007, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

    Cas Number

    380917-97-5

    Unique Ingredient Identifier (UNII)

    H821664NPK

    About Perampanel

    Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity. Although the mechanism of action through which perampanel exerts its antiepileptic effect has not been fully elucidated, this agent antagonizes the AMPA subtype of the excitatory glutamate receptor found on postsynaptic neurons in the central nervous system (CNS). This antagonistic action prevents AMPA receptor activation by glutamate and results in the inhibition of neuronal excitation, repetitive neuronal firing, and the stabilization of hyper-excited neural membranes. Glutamate, the primary excitatory neurotransmitter in the CNS, plays an important role in various neurological disorders caused by neuronal hyperexcitation.

    Perampanel [USAN:INN] Manufacturers

    A Perampanel [USAN:INN] manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Perampanel [USAN:INN], including repackagers and relabelers. The FDA regulates Perampanel [USAN:INN] manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Perampanel [USAN:INN] API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Perampanel [USAN:INN] manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Perampanel [USAN:INN] Suppliers

    A Perampanel [USAN:INN] supplier is an individual or a company that provides Perampanel [USAN:INN] active pharmaceutical ingredient (API) or Perampanel [USAN:INN] finished formulations upon request. The Perampanel [USAN:INN] suppliers may include Perampanel [USAN:INN] API manufacturers, exporters, distributors and traders.

    click here to find a list of Perampanel [USAN:INN] suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Perampanel [USAN:INN] USDMF

    A Perampanel [USAN:INN] DMF (Drug Master File) is a document detailing the whole manufacturing process of Perampanel [USAN:INN] active pharmaceutical ingredient (API) in detail. Different forms of Perampanel [USAN:INN] DMFs exist exist since differing nations have different regulations, such as Perampanel [USAN:INN] USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Perampanel [USAN:INN] DMF submitted to regulatory agencies in the US is known as a USDMF. Perampanel [USAN:INN] USDMF includes data on Perampanel [USAN:INN]'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Perampanel [USAN:INN] USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Perampanel [USAN:INN] suppliers with USDMF on PharmaCompass.

    Perampanel [USAN:INN] KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Perampanel [USAN:INN] Drug Master File in Korea (Perampanel [USAN:INN] KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Perampanel [USAN:INN]. The MFDS reviews the Perampanel [USAN:INN] KDMF as part of the drug registration process and uses the information provided in the Perampanel [USAN:INN] KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Perampanel [USAN:INN] KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Perampanel [USAN:INN] API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Perampanel [USAN:INN] suppliers with KDMF on PharmaCompass.

    Perampanel [USAN:INN] WC

    A Perampanel [USAN:INN] written confirmation (Perampanel [USAN:INN] WC) is an official document issued by a regulatory agency to a Perampanel [USAN:INN] manufacturer, verifying that the manufacturing facility of a Perampanel [USAN:INN] active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Perampanel [USAN:INN] APIs or Perampanel [USAN:INN] finished pharmaceutical products to another nation, regulatory agencies frequently require a Perampanel [USAN:INN] WC (written confirmation) as part of the regulatory process.

    click here to find a list of Perampanel [USAN:INN] suppliers with Written Confirmation (WC) on PharmaCompass.

    Perampanel [USAN:INN] NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Perampanel [USAN:INN] as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Perampanel [USAN:INN] API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Perampanel [USAN:INN] as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Perampanel [USAN:INN] and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Perampanel [USAN:INN] NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Perampanel [USAN:INN] suppliers with NDC on PharmaCompass.

    Perampanel [USAN:INN] GMP

    Perampanel [USAN:INN] Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Perampanel [USAN:INN] GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Perampanel [USAN:INN] GMP manufacturer or Perampanel [USAN:INN] GMP API supplier for your needs.

    Perampanel [USAN:INN] CoA

    A Perampanel [USAN:INN] CoA (Certificate of Analysis) is a formal document that attests to Perampanel [USAN:INN]'s compliance with Perampanel [USAN:INN] specifications and serves as a tool for batch-level quality control.

    Perampanel [USAN:INN] CoA mostly includes findings from lab analyses of a specific batch. For each Perampanel [USAN:INN] CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Perampanel [USAN:INN] may be tested according to a variety of international standards, such as European Pharmacopoeia (Perampanel [USAN:INN] EP), Perampanel [USAN:INN] JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Perampanel [USAN:INN] USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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