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Chemistry

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Also known as: 579475-24-4, Orvepitant maleate [usan], Gw823296b, Gw 823296b, Hax0h28b6w, Orvepitant (maleate)
Molecular Formula
C35H39F7N4O6
Molecular Weight
744.7  g/mol
InChI Key
IPACOHTZCSBGBV-WUXDIRCFSA-N
FDA UNII
HAX0H28B6W

Orvepitant Maleate
1 2D Structure

Orvepitant Maleate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,4S)-4-[(8aS)-6-oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide;(Z)-but-2-enedioic acid
2.1.2 InChI
InChI=1S/C31H35F7N4O2.C4H4O4/c1-18-12-23(32)4-6-26(18)27-16-24(40-10-11-41-25(17-40)5-7-28(41)43)8-9-42(27)29(44)39(3)19(2)20-13-21(30(33,34)35)15-22(14-20)31(36,37)38;5-3(6)1-2-4(7)8/h4,6,12-15,19,24-25,27H,5,7-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t19-,24+,25+,27-;/m1./s1
2.1.3 InChI Key
IPACOHTZCSBGBV-WUXDIRCFSA-N
2.1.4 Canonical SMILES
CC1=C(C=CC(=C1)F)C2CC(CCN2C(=O)N(C)C(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN5C(C4)CCC5=O.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CC1=C(C=CC(=C1)F)[C@H]2C[C@H](CCN2C(=O)N(C)[C@H](C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN5[C@H](C4)CCC5=O.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
HAX0H28B6W
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 579475-24-4

2. Orvepitant Maleate [usan]

3. Gw823296b

4. Gw 823296b

5. Hax0h28b6w

6. Orvepitant (maleate)

7. Gw-823296b

8. Orvepitant Maleate (usan)

9. (2r,4s)-n-((r)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-n-methyl-4-((s)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1h)-yl)piperidine-1-carboxamide Maleate

10. (2r,4s)-4-[(8as)-6-oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-n-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-n-methylpiperidine-1-carboxamide Maleate

11. Unii-hax0h28b6w

12. Gw 823296x Maleate

13. Schembl2179750

14. Chembl2105668

15. Glxc-15010

16. Hy-122347a

17. Cs-0110139

18. D09651

19. E98943

20. Q27279833

21. (2r,4s)-4-[(8as)-6-oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-n-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-n-methylpiperidine-1-carboxamide;(z)-but-2-enedioic Acid

22. (2r,4s)-n-((1r)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-n- Methyl-4-((8as)-6-oxohexahydropyrrolo(1,2-a)pyrazin-2(1h)-yl)piperidine-1- Carboxamide Hydrogen Mono((2z)-but-2-enedioate)

23. (2r,4s)-n-((1r)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-n-methyl-4-((8as)-6-oxohexahydropyrrolo(1,2-a)pyrazin-2(1h)-yl)piperidine-1-carboxamide Hydrogen Mono((2z)-but-2-enedioate)

24. 1-piperidinecarboxamide, N-((1r)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2- Methylphenyl)-4-((8as)-hexahydro-6-oxopyrrolo(1,2-a)pyrazin-2(1h)-yl)-n-methyl-, (2r,4s)-, (2z)-2-butenedioate (1:1)

25. 1-piperidinecarboxamide, N-((1r)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-4-((8as)-hexahydro-6-oxopyrrolo(1,2-a)pyrazin-2(1h)-yl)-n-methyl-, (2r,4s)-, (2z)-2-butenedioate (1:1)

2.4 Create Date
2009-10-12
3 Chemical and Physical Properties
Molecular Weight 744.7 g/mol
Molecular Formula C35H39F7N4O6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count6
Exact Mass744.27578211 g/mol
Monoisotopic Mass744.27578211 g/mol
Topological Polar Surface Area122 Ų
Heavy Atom Count52
Formal Charge0
Complexity1140
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

ABOUT THIS PAGE

Looking for 579475-24-4 / Orvepitant Maleate API manufacturers, exporters & distributors?

Orvepitant Maleate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Orvepitant Maleate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Orvepitant Maleate manufacturer or Orvepitant Maleate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Orvepitant Maleate manufacturer or Orvepitant Maleate supplier.

PharmaCompass also assists you with knowing the Orvepitant Maleate API Price utilized in the formulation of products. Orvepitant Maleate API Price is not always fixed or binding as the Orvepitant Maleate Price is obtained through a variety of data sources. The Orvepitant Maleate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Orvepitant Maleate

Synonyms

579475-24-4, Orvepitant maleate [usan], Gw823296b, Gw 823296b, Hax0h28b6w, Orvepitant (maleate)

Cas Number

579475-24-4

Unique Ingredient Identifier (UNII)

HAX0H28B6W

Orvepitant Maleate Manufacturers

A Orvepitant Maleate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Orvepitant Maleate, including repackagers and relabelers. The FDA regulates Orvepitant Maleate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Orvepitant Maleate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Orvepitant Maleate Suppliers

A Orvepitant Maleate supplier is an individual or a company that provides Orvepitant Maleate active pharmaceutical ingredient (API) or Orvepitant Maleate finished formulations upon request. The Orvepitant Maleate suppliers may include Orvepitant Maleate API manufacturers, exporters, distributors and traders.

Orvepitant Maleate GMP

Orvepitant Maleate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Orvepitant Maleate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Orvepitant Maleate GMP manufacturer or Orvepitant Maleate GMP API supplier for your needs.

Orvepitant Maleate CoA

A Orvepitant Maleate CoA (Certificate of Analysis) is a formal document that attests to Orvepitant Maleate's compliance with Orvepitant Maleate specifications and serves as a tool for batch-level quality control.

Orvepitant Maleate CoA mostly includes findings from lab analyses of a specific batch. For each Orvepitant Maleate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Orvepitant Maleate may be tested according to a variety of international standards, such as European Pharmacopoeia (Orvepitant Maleate EP), Orvepitant Maleate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Orvepitant Maleate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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