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Synopsis

Synopsis

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Chemistry

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Also known as: Ly3537982, C2vj83psn7, Ly-3537982, Refchem:1093882, 2771246-13-8, Kras g12c inhibitor 19
Molecular Formula
C25H19ClF2N4O3S
Molecular Weight
529.0  g/mol
InChI Key
OZUPICRWMLEFCS-LBPRGKRZSA-N
FDA UNII
C2VJ83PSN7

Olomorasib
Olomorasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, olomorasib selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.
1 2D Structure

Olomorasib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(13aS)-10-chloro-8-fluoro-6-oxo-2-prop-2-enoyl-1,3,4,12,13,13a-hexahydropyrazino[2,1-d][1,5]benzoxazocin-9-yl]-2-amino-7-fluoro-1-benzothiophene-3-carbonitrile
2.1.2 InChI
InChI=1S/C25H19ClF2N4O3S/c1-2-18(33)31-6-7-32-12(11-31)5-8-35-22-14(25(32)34)9-17(28)20(21(22)26)13-3-4-16(27)23-19(13)15(10-29)24(30)36-23/h2-4,9,12H,1,5-8,11,30H2/t12-/m0/s1
2.1.3 InChI Key
OZUPICRWMLEFCS-LBPRGKRZSA-N
2.2 Other Identifiers
2.2.1 UNII
C2VJ83PSN7
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Ly3537982

2. C2vj83psn7

3. Ly-3537982

4. Refchem:1093882

5. 2771246-13-8

6. Kras G12c Inhibitor 19

7. 2649788-46-3

8. 2-amino-4-[(4as)-8-chloro-10-fluoro-2,3,4,4a,5,6-hexahydro-12-oxo-3-(1-oxo-2-propen-1-yl)-1h,12h-pyrazino[2,1-d][1,5]benzoxazocin-9-yl]-7-fluorobenzo[b]thiophene-3-carbonitrile

9. 4-((s)-3-acryloyl-8-chloro-10-fluoro-12-oxo-2,3,4,4a,5,6-hexahydro-1h,12h-benzo[b]pyrazino[1,2-e][1,5]oxazocin-9-yl)-2-amino-7-fluorobenzo[b]thiophene-3-carbonitrile

10. Olomorasib [inn]

11. Orb1690700

12. Schembl23496727

13. Ex-a6653

14. Nsc853962

15. Akos040757943

16. Nsc-853962

17. Da-64768

18. Hy-132980

19. Cs-0311440

20. F78016

21. 2-amino-4-[(4as)-8-chloro-10-fluoro-2,3,4,4a,5,6-hexahydro-12-oxo-3-(1-oxo-2-propen-1-yl)-1h,12h-pyrazino[2,1-d][1,5]benzoxazocin-9-yl]-7-fluoro-benzo[b]thiophene-3-carbonitrile

22. 2-amino-4-[(4r)-8-chloro-10-fluoro-12-oxo-3-(prop-2-enoyl)-2,3,4,4a,5,6-hexahydro-1h,12h-pyrazino[2,1-d][1,5]benzoxazocin-9-yl]-7-fluoro-1-benzothiophene-3-carbonitrile

23. 4-[(13as)-10-chloro-8-fluoro-6-oxo-2-prop-2-enoyl-1,3,4,12,13,13a-hexahydropyrazino[2,1-d][1,5]benzoxazocin-9-yl]-2-amino-7-fluoro-1-benzothiophene-3-carbonitrile

24. Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[(4as)-8-chloro-10-fluoro-2,3,4,4a,5,6-hexahydro-12-oxo-3-(1-oxo-2-propen-1-yl)-1h,12h-pyrazino[2,1-d][1,5]benzoxazocin-9-yl]-7-fluoro-, (4r)-

2.4 Create Date
2021-08-21
3 Chemical and Physical Properties
Molecular Weight 529.0 g/mol
Molecular Formula C25H19ClF2N4O3S
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area128
Heavy Atom Count36
Formal Charge0
Complexity952
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2771246-13-8 / Olomorasib API manufacturers, exporters & distributors?

Olomorasib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Olomorasib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Olomorasib manufacturer or Olomorasib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Olomorasib manufacturer or Olomorasib supplier.

API | Excipient name

Olomorasib

Synonyms

Ly3537982, C2vj83psn7, Ly-3537982, Refchem:1093882, 2771246-13-8, Kras g12c inhibitor 19

Cas Number

2771246-13-8

Unique Ingredient Identifier (UNII)

C2VJ83PSN7

About Olomorasib

Olomorasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, olomorasib selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.

Olomorasib Manufacturers

A Olomorasib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Olomorasib, including repackagers and relabelers. The FDA regulates Olomorasib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Olomorasib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Olomorasib Suppliers

A Olomorasib supplier is an individual or a company that provides Olomorasib active pharmaceutical ingredient (API) or Olomorasib finished formulations upon request. The Olomorasib suppliers may include Olomorasib API manufacturers, exporters, distributors and traders.

Olomorasib GMP

Olomorasib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Olomorasib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Olomorasib GMP manufacturer or Olomorasib GMP API supplier for your needs.

Olomorasib CoA

A Olomorasib CoA (Certificate of Analysis) is a formal document that attests to Olomorasib's compliance with Olomorasib specifications and serves as a tool for batch-level quality control.

Olomorasib CoA mostly includes findings from lab analyses of a specific batch. For each Olomorasib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Olomorasib may be tested according to a variety of international standards, such as European Pharmacopoeia (Olomorasib EP), Olomorasib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Olomorasib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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