Find Olinciguat manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

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$ 0

GLOBAL SALES INFORMATION

US Medicaid

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Annual Reports

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Regulatory FDF Prices

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Chemistry

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Also known as: 1628732-62-6, Olinciguat [inn], Iw-1701, Olinciguat [usan], Iw1701, Pd5f4zxd21
Molecular Formula
C21H16F5N7O3
Molecular Weight
509.4  g/mol
InChI Key
YWQFJNWMWZMXRW-HXUWFJFHSA-N
FDA UNII
PD5F4ZXD21

Olinciguat
Olinciguat is an orally bioavailable stimulator of soluble guanylate cyclase (sGC), with potential anti-inflammatory and vasodilating activities. Upon oral administration, olinciguat targets, allosterically binds to and enhances the nitric oxide (NO)-dependent catalytic activity of sGC. This enhances NO-sGC signaling and increases the formation of the intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This enhances NO/cGMP-mediated muscle relaxation, suppresses leukocyte-endothelial interactions and promotes vascular anti-inflammatory effects. The NO/sGC/cGMP signaling pathway plays an important role in vasodilation, blood flow and inflammatory processes. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from GTP in response to NO binding to heme.
1 2D Structure

Olinciguat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R)-3,3,3-trifluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]methyl]-2-hydroxypropanamide
2.1.2 InChI
InChI=1S/C21H16F5N7O3/c22-12-4-2-1-3-11(12)9-33-16(14-5-6-36-32-14)7-15(31-33)18-28-8-13(23)17(30-18)29-10-20(35,19(27)34)21(24,25)26/h1-8,35H,9-10H2,(H2,27,34)(H,28,29,30)/t20-/m1/s1
2.1.3 InChI Key
YWQFJNWMWZMXRW-HXUWFJFHSA-N
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)CN2C(=CC(=N2)C3=NC=C(C(=N3)NCC(C(=O)N)(C(F)(F)F)O)F)C4=NOC=C4)F
2.1.5 Isomeric SMILES
C1=CC=C(C(=C1)CN2C(=CC(=N2)C3=NC=C(C(=N3)NC[C@@](C(=O)N)(C(F)(F)F)O)F)C4=NOC=C4)F
2.2 Other Identifiers
2.2.1 UNII
PD5F4ZXD21
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1628732-62-6

2. Olinciguat [inn]

3. Iw-1701

4. Olinciguat [usan]

5. Iw1701

6. Pd5f4zxd21

7. (2r)-3,3,3-trifluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]methyl]-2-hydroxypropanamide

8. Olinciguat (usan/inn)

9. Olinciguat [usan:inn]

10. Unii-pd5f4zxd21

11. Olinciguat [who-dd]

12. Chembl4297616

13. Schembl16081945

14. Gtpl10213

15. Bdbm321744

16. Db15238

17. Iw-1701iw-1701

18. Us10183021, Compound I-531

19. Ac-31551

20. Hy-109066

21. Cs-0033431

22. D11475

23. D87219

24. (2~{r})-3,3,3-trifluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]methyl]-2-hydroxypropanamide

25. (2r)-3,3,3-trifluoro-2-(((5-fluoro-2-(1-((2-fluorophenyl)methyl)-5-(1,2-oxazol-3-yl)-1h-pyrazol-3-yl)pyrimidin-4-yl)amino)methyl)-2-hydroxypropanamide

26. Propanamide, 3,3,3-trifluoro-2-(((5-fluoro-2-(1-((2-fluorophenyl)methyl)-5-(3-isoxazolyl)-1h-pyrazol-3-yl)-4-pyrimidinyl)amino)methyl)-2-hydroxy-, (2r)-

2.4 Create Date
2015-02-13
3 Chemical and Physical Properties
Molecular Weight 509.4 g/mol
Molecular Formula C21H16F5N7O3
XLogP32.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count13
Rotatable Bond Count8
Exact Mass509.12347821 g/mol
Monoisotopic Mass509.12347821 g/mol
Topological Polar Surface Area145 Ų
Heavy Atom Count36
Formal Charge0
Complexity768
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of sickle cell disease


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ABOUT THIS PAGE

Looking for 1628732-62-6 / Olinciguat API manufacturers, exporters & distributors?

Olinciguat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Olinciguat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Olinciguat manufacturer or Olinciguat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Olinciguat manufacturer or Olinciguat supplier.

PharmaCompass also assists you with knowing the Olinciguat API Price utilized in the formulation of products. Olinciguat API Price is not always fixed or binding as the Olinciguat Price is obtained through a variety of data sources. The Olinciguat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Olinciguat

Synonyms

1628732-62-6, Olinciguat [inn], Iw-1701, Olinciguat [usan], Iw1701, Pd5f4zxd21

Cas Number

1628732-62-6

Unique Ingredient Identifier (UNII)

PD5F4ZXD21

About Olinciguat

Olinciguat is an orally bioavailable stimulator of soluble guanylate cyclase (sGC), with potential anti-inflammatory and vasodilating activities. Upon oral administration, olinciguat targets, allosterically binds to and enhances the nitric oxide (NO)-dependent catalytic activity of sGC. This enhances NO-sGC signaling and increases the formation of the intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This enhances NO/cGMP-mediated muscle relaxation, suppresses leukocyte-endothelial interactions and promotes vascular anti-inflammatory effects. The NO/sGC/cGMP signaling pathway plays an important role in vasodilation, blood flow and inflammatory processes. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from GTP in response to NO binding to heme.

Olinciguat Manufacturers

A Olinciguat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Olinciguat, including repackagers and relabelers. The FDA regulates Olinciguat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Olinciguat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Olinciguat Suppliers

A Olinciguat supplier is an individual or a company that provides Olinciguat active pharmaceutical ingredient (API) or Olinciguat finished formulations upon request. The Olinciguat suppliers may include Olinciguat API manufacturers, exporters, distributors and traders.

Olinciguat GMP

Olinciguat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Olinciguat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Olinciguat GMP manufacturer or Olinciguat GMP API supplier for your needs.

Olinciguat CoA

A Olinciguat CoA (Certificate of Analysis) is a formal document that attests to Olinciguat's compliance with Olinciguat specifications and serves as a tool for batch-level quality control.

Olinciguat CoA mostly includes findings from lab analyses of a specific batch. For each Olinciguat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Olinciguat may be tested according to a variety of international standards, such as European Pharmacopoeia (Olinciguat EP), Olinciguat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Olinciguat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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