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Chemistry

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Also known as: 113317-61-6, 119934-51-9, (+/-)-niguldipine hydrochloride, Niguldipine hydrochloride, (+/-)-, Nsc-617553, Niguldipine (hydrochloride)
Molecular Formula
C36H40ClN3O6
Molecular Weight
646.2  g/mol
InChI Key
MHOSUIMBPQVOEU-UHFFFAOYSA-N
FDA UNII
5QC11TLQ7K

Nsc-617553
1 2D Structure

Nsc-617553

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-O-[3-(4,4-diphenylpiperidin-1-yl)propyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride
2.1.2 InChI
InChI=1S/C36H39N3O6.ClH/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29;/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3;1H
2.1.3 InChI Key
MHOSUIMBPQVOEU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl
2.2 Other Identifiers
2.2.1 UNII
5QC11TLQ7K
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-((4,4-diphenyl-1-piperidinyl)propyl)-5-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate Hydrochloride

2. 3-methyl-5-(3-(4,4-diphenyl-1-piperidinyl)propyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

3. B 844-39

4. B 859-35

5. B8509-035

6. B859-35

7. Dexniguldipine

8. Dnig

9. Niguldipine

10. Niguldipine Fumarate

11. Niguldipine Hydrobromide

12. Niguldipine Maleate

2.3.2 Depositor-Supplied Synonyms

1. 113317-61-6

2. 119934-51-9

3. (+/-)-niguldipine Hydrochloride

4. Niguldipine Hydrochloride, (+/-)-

5. Nsc-617553

6. Niguldipine (hydrochloride)

7. 5qc11tlq7k

8. B-844-39

9. 5-o-[3-(4,4-diphenylpiperidin-1-yl)propyl] 3-o-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride

10. 134886-09-2 (hcl)

11. Dsstox_cid_26318

12. Dsstox_rid_81534

13. Dsstox_gsid_46318

14. 3,5-pyridinedicarboxylic Acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl Ester, Hydrochloride (1:1)

15. 3-(3-(4,4-diphenylpiperidin-1-yl)propyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

16. 3-3-(4,4-diphenyl-1-piperidyl)propyl 5-methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

17. (+/-) -niguldipine Hydrochloride (1:x)

18. Cas-102992-93-8

19. Unii-5qc11tlq7k

20. Niguldipine Hcl

21. Dexniquldipine Hcl

22. Dl-niguldipine Hydrochloride

23. Schembl9001404

24. Chembl1965632

25. Dtxsid20872307

26. Tox21_112014

27. Nsc617553

28. Tox21_112014_1

29. Ccg-207993

30. Ncgc00025014-03

31. 134886-09-2

32. J-002947

33. Q27262742

34. 102992-93-8

35. 3,5-pyridinedicarboxylic Acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[3-(4,4-diphenyl-1-piperidinyl)propyl] 5-methyl Ester, Xhydrochloride

36. 3-(4,4-diphenylpiperidin-1-yl)propyl Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrogen Chloride (1:1)

37. 3-methyl 5-[3-(4,4-diphenyl-1-piperidinyl)-propyl] (-)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate Hydrochloride

38. 3-methyl 5-[3-(4,4-diphenylpiperid-1-yl)-propyl] (+)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate Hydrochloride

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 646.2 g/mol
Molecular Formula C36H40ClN3O6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Exact Mass645.2605637 g/mol
Monoisotopic Mass645.2605637 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count46
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


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Looking for 119934-51-9 / Nsc-617553 API manufacturers, exporters & distributors?

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PharmaCompass offers a list of Nsc-617553 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nsc-617553 manufacturer or Nsc-617553 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nsc-617553 manufacturer or Nsc-617553 supplier.

PharmaCompass also assists you with knowing the Nsc-617553 API Price utilized in the formulation of products. Nsc-617553 API Price is not always fixed or binding as the Nsc-617553 Price is obtained through a variety of data sources. The Nsc-617553 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nsc-617553

Synonyms

113317-61-6, 119934-51-9, (+/-)-niguldipine hydrochloride, Niguldipine hydrochloride, (+/-)-, Niguldipine (hydrochloride), 5qc11tlq7k

Cas Number

119934-51-9

Unique Ingredient Identifier (UNII)

5QC11TLQ7K

Nsc-617553 Manufacturers

A Nsc-617553 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nsc-617553, including repackagers and relabelers. The FDA regulates Nsc-617553 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nsc-617553 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nsc-617553 Suppliers

A Nsc-617553 supplier is an individual or a company that provides Nsc-617553 active pharmaceutical ingredient (API) or Nsc-617553 finished formulations upon request. The Nsc-617553 suppliers may include Nsc-617553 API manufacturers, exporters, distributors and traders.

Nsc-617553 GMP

Nsc-617553 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nsc-617553 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nsc-617553 GMP manufacturer or Nsc-617553 GMP API supplier for your needs.

Nsc-617553 CoA

A Nsc-617553 CoA (Certificate of Analysis) is a formal document that attests to Nsc-617553's compliance with Nsc-617553 specifications and serves as a tool for batch-level quality control.

Nsc-617553 CoA mostly includes findings from lab analyses of a specific batch. For each Nsc-617553 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nsc-617553 may be tested according to a variety of international standards, such as European Pharmacopoeia (Nsc-617553 EP), Nsc-617553 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nsc-617553 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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