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Neomycin Sulfate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

23 API Suppliers, 11 USDMF, 5 CEP/COS, 2 JDMF, 1 KDMF, 22 NDC API, 10 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

DOSSIERs // Finished Dosage Formulations

158 Dossiers, 114 FDA Orange Book, 7 Europe, 7 Canada, 4 South Africa, 26 Listed Dossiers

DRUG PRODUCT COMPOSITION

OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM, OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM, CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM, SUSPENSION/DROPS;OTIC - EQ 3MG BASE/ML;10MG/ML;EQ 3.3MG BASE/ML;0.5MG/ML, OINTMENT;OPHTHALMIC - EQ 400 UNITS/GM;EQ 3.5MG BASE/GM;EQ 10,000 UNITS/GM

OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM
OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM
CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM
SUSPENSION/DROPS;OTIC - EQ 3MG BASE/ML;10MG/ML;EQ 3.3MG BASE/ML;0.5MG/ML
OINTMENT;OPHTHALMIC - EQ 400 UNITS/GM;EQ 3.5MG BASE/GM;EQ 10,000 UNITS/GM

RELATED EXCIPIENT COMPANIES

Suppliers, 35 Kerry, 32 BASF, 19 Actylis, 17 Seppic, 15 Microlex e.U, 12 Nanjing Well Pharmaceutical, 11 Roquette, 10 Corel Pharma Chem, 10 Gangwal Chemicals, 6 Lonza Capsugel, 6 Gangwal Healthcare, 6 SPI Pharma, 4 Boai NKY Pharmaceuticals Ltd, 4 Finar, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 4 Ideal Cures Pvt Ltd, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 3 DFE Pharma, 3 Sigachi Industries, 3 Kima Chemical, 3 DKSH, 2 Seqens, 2 Ulanqab Kema New Material, 2 Nippon Fine Chemical, 2 Nanjing Bold Chemical, 2 Vasa Pharmachem, 2 Nomisma Healthcare, 2 The Dow Chemical Company, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Aeon Procare, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Prachin Chemical, 1 Pfanstiehl, 1 Jai Radhe Sales, 1 ACG Worldwide, 1 Zhejiang Huakang Pharmaceutical, 1 Pharmatrans-Sanaq, 1 Qualicaps, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Rochem International Inc

EXCIPIENTS BY APPLICATIONS

52 Fillers, Diluents & Binders, 46 Coating Systems & Additives, 41 Solubilizers, 35 Topical, 27 Parenteral, 24 Direct Compression, 24 Controlled & Modified Release, 19 Lubricants & Glidants, 18 Film Formers & Plasticizers, 17 Thickeners and Stabilizers, 16 Granulation, 14 Co-Processed Excipients, 11 Emulsifying Agents, 10 Taste Masking, 7 Surfactant & Foaming Agents, 6 Chewable & Orodispersible Aids, 6 API Stability Enhancers, 5 Empty Capsules, 4 Disintegrants & Superdisintegrants, 4 Vegetarian Capsules, 2 Coloring Agents, 2 Rheology Modifiers, 1 Soft Gelatin

GLOBAL SALES INFORMATION

9 US Medicaid Prescriptions, 8 Finished Drug Prices

MARKET PLACE

52 APIs, 4 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

3 EDQM Standards, 1 USP Standards, 2 Other Ref. Standards

DIGITAL CONTENT

6 News

6 News

Also known as: Neomycin sulfate, 1405-10-3, Neomycin trisulfate hydrate, Akos016010116

Molecular Formula

C₂₃H₄₈N₆O₁₇S

Molecular Weight

712.7 g/mol

InChI Key

OIXVKQDWLFHVGR-VTSVPHRWSA-N

Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis.

1 2D Structure

Neomycin Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid

2.1.2 InChI

InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13+,14+,15-,16-,17-,18-,19+,20+,21-,22?,23+;/m1./s1

2.1.3 InChI Key

OIXVKQDWLFHVGR-VTSVPHRWSA-N

2.1.4 Canonical SMILES

C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

2.1.5 Isomeric SMILES

C1[C@H]([C@@H]([C@@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@H]([C@H](O3)CO)OC4[C@@H]([C@H]([C@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Neomycin

2. Neomycin Palmitate

3. Neomycin Sulfate

2.2.2 Depositor-Supplied Synonyms

1. Neomycin Sulfate

2. 1405-10-3

3. Neomycin Trisulfate Hydrate

4. Akos016010116

2.3 Create Date

2013-05-31

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₄₈N₆O₁₇S
Molecular Weight	712.7 g/mol
Hydrogen Bond Donor Count	15
Hydrogen Bond Acceptor Count	23
Rotatable Bond Count	9
Exact Mass	712.27966526 g/mol
Monoisotopic Mass	712.27966526 g/mol
Topological Polar Surface Area	436 Å²
Heavy Atom Count	47
Formal Charge	0
Complexity	953
Isotope Atom Count	0
Defined Atom Stereocenter Count	18
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Neomycin sulfate
Drug Label	Neomycin Sulfate Tablets, USP, for oral administration, contain neomycin which is an antibiotic obtained from the metabolic products of the actinomycete Streptomycesfradiae. Structurally, neomycin sulfate may be represented as follows:Chemically, i...
Active Ingredient	Neomycin sulfate
Dosage Form	Tablet
Route	Oral
Strength	500mg
Market Status	Prescription
Company	Oman Pharm Products; Teva; X Gen Pharms

2 of 2
Drug Name	Neomycin sulfate
Drug Label	Neomycin Sulfate Tablets, USP, for oral administration, contain neomycin which is an antibiotic obtained from the metabolic products of the actinomycete Streptomycesfradiae. Structurally, neomycin sulfate may be represented as follows:Chemically, i...
Active Ingredient	Neomycin sulfate
Dosage Form	Tablet
Route	Oral
Strength	500mg
Market Status	Prescription
Company	Oman Pharm Products; Teva; X Gen Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Aminoglycosides [CS]; Aminoglycoside Antibacterial [EPC]