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Looking for 1357470-29-1 / Narazaciclib API manufacturers, exporters & distributors?

Narazaciclib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Narazaciclib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Narazaciclib manufacturer or Narazaciclib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Narazaciclib manufacturer or Narazaciclib supplier.

PharmaCompass also assists you with knowing the Narazaciclib API Price utilized in the formulation of products. Narazaciclib API Price is not always fixed or binding as the Narazaciclib Price is obtained through a variety of data sources. The Narazaciclib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Narazaciclib

Synonyms

1357470-29-1, On123300, On-123300, Qj8ro3296g, Chembl3115681, Pyrido(2,3-d)pyrimidine-6-carbonitrile, 8-cyclopentyl-7,8-dihydro-2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxo-

Cas Number

1357470-29-1

Unique Ingredient Identifier (UNII)

QJ8RO3296G

About Narazaciclib

Narazaciclib is an orally bioavailable inhibitor of NUAK family SNF1-like kinase 1 (AMPK-related protein kinase 5; ARK5), and the cyclin-dependent kinases 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration,narazaciclib specifically binds to and inhibits ARK5, which interferes with the activation of ARK5-mediated signal transduction pathways and reduces cell proliferation in cancer cells that overexpress ARK5. In addition, ON 123300 inhibits CDK4 and 6 and prevents the phosphorylation of retinoblastoma (Rb) protein in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, which causes G1 phase cell cycle arrest, suppresses DNA synthesis and inhibits cancer cell growth. ARK5, a member of the AMP-activated protein kinase (AMPK) family, is associated with tumor growth and invasion. Overexpression of CDK4/6, which is seen in certain types of cancer, causes cell cycle deregulation.

Narazaciclib Manufacturers

A Narazaciclib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Narazaciclib, including repackagers and relabelers. The FDA regulates Narazaciclib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Narazaciclib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Narazaciclib Suppliers

A Narazaciclib supplier is an individual or a company that provides Narazaciclib active pharmaceutical ingredient (API) or Narazaciclib finished formulations upon request. The Narazaciclib suppliers may include Narazaciclib API manufacturers, exporters, distributors and traders.

Narazaciclib GMP

Narazaciclib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Narazaciclib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Narazaciclib GMP manufacturer or Narazaciclib GMP API supplier for your needs.

Narazaciclib CoA

A Narazaciclib CoA (Certificate of Analysis) is a formal document that attests to Narazaciclib's compliance with Narazaciclib specifications and serves as a tool for batch-level quality control.

Narazaciclib CoA mostly includes findings from lab analyses of a specific batch. For each Narazaciclib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Narazaciclib may be tested according to a variety of international standards, such as European Pharmacopoeia (Narazaciclib EP), Narazaciclib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Narazaciclib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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