N99027V28J

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Also known as: 252188-71-9, Unii-n99027v28j, Ceftobiprole medocaril (sodium), Bal5788, Ceftobiprole medocaril sodium, N99027v28j

Molecular Formula

C₂₆H₂₅N₈NaO₁₁S₂

Molecular Weight

712.6 g/mol

InChI Key

MFAWUGGPPMTWPU-LCJFHXTKSA-M

FDA UNII

N99027V28J

Ceftobiprole Medocaril is a water-soluble prodrug of ceftobiprole, a pyrrolidinone cephalosporin antibiotic, with bactericidal activity. Ceftobiprole binds to and inactivates penicillin-binding proteins (PBPs), enzymes involved in the terminal stages of bacterial cell wall assembly and cell wall reshaping during bacterial growth and division. This agent exhibits a broad spectrum of activity against gram-negative and gram-positive pathogens including methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA). Ceftobiprole is refractory to hydrolysis by class A and class C lactamases.

1 2D Structure

N99027V28J

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-hydroxyiminoacetyl]amino]-3-[(E)-[1-[(3R)-1-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxycarbonyl]pyrrolidin-3-yl]-2-oxopyrrolidin-3-ylidene]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.1.2 InChI

InChI=1S/C26H26N8O11S2.Na/c1-10-14(45-26(41)44-10)8-43-25(40)32-4-3-13(7-32)33-5-2-11(20(33)36)6-12-9-46-22-16(21(37)34(22)17(12)23(38)39)28-19(35)15(30-42)18-29-24(27)47-31-18;/h6,13,16,22,42H,2-5,7-9H2,1H3,(H,28,35)(H,38,39)(H2,27,29,31);/q;+1/p-1/b11-6+,30-15-;/t13-,16-,22-;/m1./s1

2.1.3 InChI Key

MFAWUGGPPMTWPU-LCJFHXTKSA-M

2.1.4 Canonical SMILES

CC1=C(OC(=O)O1)COC(=O)N2CCC(C2)N3CCC(=CC4=C(N5C(C(C5=O)NC(=O)C(=NO)C6=NSC(=N6)N)SC4)C(=O)[O-])C3=O.[Na+]

2.1.5 Isomeric SMILES

CC1=C(OC(=O)O1)COC(=O)N2CC[C@H](C2)N3CC/C(=C\C4=C(N5[C@@H]([C@@H](C5=O)NC(=O)/C(=N\O)/C6=NSC(=N6)N)SC4)C(=O)[O-])/C3=O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

N99027V28J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bal 5788

2. Bal-5788

3. Bal5788

4. Ceftobiprole Medocaril (inn)

5. Ceftobiprole Medocaril Free Acid

6. Ceftobiprole Medocaril Sodium

2.3.2 Depositor-Supplied Synonyms

1. 252188-71-9

2. Unii-n99027v28j

3. Ceftobiprole Medocaril (sodium)

4. Bal5788

5. Ceftobiprole Medocaril Sodium

6. N99027v28j

7. Bal5788-001

8. Ro 65-5788

9. Ro-65-5788

10. Bal-5788

11. Sodium;(6r,7r)-7-[[(2z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-hydroxyiminoacetyl]amino]-3-[(e)-[1-[(3r)-1-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxycarbonyl]pyrrolidin-3-yl]-2-oxopyrrolidin-3-ylidene]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

12. Ceftobiprole Medocaril (usan)

13. Ceftobiprole Medocaril [usan]

14. Ceftobiprole Medocaril Sodium Salt

15. Ro-655788

16. Bal-5788-001

17. Schembl4401305

18. Dtxsid601021562

19. Ceftobiprole Medocaril [usan:inn]

20. Ceftobiprole Medocaril [mart.]

21. Hy-106574a

22. Ceftobiprole Medocaril [ema Epar]

23. Cs-0103172

24. Ceftobiprole Medocaril Sodium [who-dd]

25. Ro-65-5788/001

26. Ceftobiprole Medocaril Sodium Salt [mi]

27. D08886

28. (6r,7r)-7-(((2z)-(5-amino-1,2,4-thiadiazol-3-yl)(hydroxyimino)-acetyl)amino)-3-((e)-((3'r)-1'-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2-oxo(1,3'-bipyrrolidin)-3-ylidene)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid Monosodium Salt

29. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2z)-(5-amino-1,2,4-thiadiazol-3-yl) (hydroxyimino)acetyl)amino)-3-((e)-((3'r)-1'-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2-oxo(1,3'-bipyrrolidin)-3-ylidene)methyl)-8-oxo-, Monosodium Salt, (6r,7r)-

2.4 Create Date

2019-01-15

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₂₅N₈NaO₁₁S₂
Molecular Weight	712.6 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	9
Exact Mass	712.09819027 g/mol
Monoisotopic Mass	712.09819027 g/mol
Topological Polar Surface Area	313 Å²
Heavy Atom Count	48
Formal Charge	0
Complexity	1570
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2