MolPort-002-130-141

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

31 API Suppliers, 19 USDMF, 14 CEP/COS, 6 EU WC, 5 NDC API, 16 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

5 Suppliers

5 Suppliers

DOSSIERs // Finished Dosage Formulations

172 Dossiers, 118 FDA Orange Book, 5 Europe, 19 Canada, 6 Australia, 6 South Africa, 18 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 10MG, TABLET;ORAL - 1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - 2.5MG, TABLET;ORAL - 2MG, TABLET;ORAL - 3MG, TABLET;ORAL - 4MG, TABLET;ORAL - 5MG, TABLET;ORAL - 6MG, TABLET;ORAL - 7.5MG

TABLET;ORAL - 10MG
TABLET;ORAL - 1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - 2.5MG
TABLET;ORAL - 2MG
TABLET;ORAL - 3MG
TABLET;ORAL - 4MG
TABLET;ORAL - 5MG
TABLET;ORAL - 6MG
TABLET;ORAL - 7.5MG

RELATED EXCIPIENT COMPANIES

Suppliers, 37 Kerry, 21 SPI Pharma, 16 Roquette, 14 Microlex e.U, 10 Gangwal Healthcare, 10 BASF, 10 Sigachi Industries, 10 Corel Pharma Chem, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 7 Seppic, 7 Gangwal Chemicals, 6 Lonza Capsugel, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 6 DFE Pharma, 5 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 3 Kima Chemical, 3 Prachin Chemical, 3 Vasa Pharmachem, 2 The Dow Chemical Company, 2 Rochem International Inc, 2 Actylis, 2 Pharmatrans-Sanaq, 1 Ulanqab Kema New Material, 1 ACG Worldwide, 1 Qualicaps, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 1 DKSH, 1 Pfanstiehl, 1 Jai Radhe Sales, 1 Nanjing Well Pharmaceutical

EXCIPIENTS BY APPLICATIONS

77 Fillers, Diluents & Binders, 40 Coating Systems & Additives, 37 Direct Compression, 23 Controlled & Modified Release, 23 Granulation, 21 Disintegrants & Superdisintegrants, 17 Co-Processed Excipients, 16 Thickeners and Stabilizers, 16 Chewable & Orodispersible Aids, 15 Taste Masking, 11 Lubricants & Glidants, 8 Solubilizers, 8 Parenteral, 6 Film Formers & Plasticizers, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 3 Emulsifying Agents, 3 Rheology Modifiers, 2 Coloring Agents

GLOBAL SALES INFORMATION

23 US Medicaid Prescriptions, 21 Finished Drug Prices

MARKET PLACE

9 APIs, 12 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

1 BioAnalytical Methods, 2 Analytical Solutions, 2 EDQM Standards, 1 Other Ref. Standards

DIGITAL CONTENT

3 Data Compilations & Company Tracker #PharmaFlow, 11 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

649

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

118

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

1,445.00

Annual Reports

50.00

FDF Market Place

EXCIPIENTS

204

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 129-06-6, Sodium warfarin, Jantoven, Aldocumar, Athrombin, Marevan

Molecular Formula

C₁₉H₁₅NaO₄

Molecular Weight

330.3 g/mol

InChI Key

KYITYFHKDODNCQ-UHFFFAOYSA-M

FDA UNII

6153CWM0CL

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

1 2D Structure

MolPort-002-130-141

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate

2.1.2 InChI

InChI=1S/C19H16O4.Na/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22;/h2-10,15,21H,11H2,1H3;/q;+1/p-1

2.1.3 InChI Key

KYITYFHKDODNCQ-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

6153CWM0CL

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2h-1-benzopyran-2-one

2. Aldocumar

3. Apo-warfarin

4. Coumadin

5. Coumadine

6. Gen-warfarin

7. Marevan

8. Potassium, Warfarin

9. Sodium, Warfarin

10. Tedicumar

11. Warfant

12. Warfarin

13. Warfarin Potassium

2.3.2 Depositor-Supplied Synonyms

1. 129-06-6

2. Sodium Warfarin

3. Jantoven

4. Aldocumar

5. Athrombin

6. Marevan

7. Zoocoumarin Sodium Salt

8. Warfarin Sodium Salt

9. Apo-warfarin

10. Warfarin (sodium)

11. Sodium 2-oxo-3-(3-oxo-1-phenylbutyl)-2h-chromen-4-olate

12. Warfarin Sodium [usp]

13. 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin Sodium Salt

14. 6153cwm0cl

15. Warfarin Sodium Clathrate

16. 2h-1-benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, Sodium Salt

17. 67430-45-9

18. Coumadine

19. Dicusat

20. Marevam

21. Orfarin

22. Tintorane

23. Varfine

24. Warcoumin

25. Warfarin Sodium (usp)

26. Warfilone

27. Simarc

28. Coumadin Sodium

29. Sodium Coumadin

30. Uniwarfin

31. Ratsul Soluble

32. Coumadan Sodico

33. Coumafene Sodium

34. Warfarinsodium

35. Sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate

36. Warfarin, Sodium Salt

37. Caswell No. 903a

38. Warfarin-sodium

39. (+-)-warfarin Sodium

40. Warfarin, Sodium Deriv.

41. Einecs 204-929-4

42. 3-(3-oxo-1-phenylbutyl)-4-sodiooxy-2h-1-benzopyran-2-one

43. Epa Pesticide Chemical Code 086003

44. Unii-6153cwm0cl

45. Warfarinum Natricum

46. Coumadin (tn)

47. Jantoven (tn)

48. Einecs 226-909-4

49. Sodium, ((3-(alpha-acetonylbenzyl)-2-oxo-2h-1-benzopyran-4-yl)oxy)-

50. Warfarin Sodium Clatharate

51. Schembl7826

52. Dsstox_cid_15010

53. Dsstox_rid_79236

54. Dsstox_gsid_35010

55. Mls001074341

56. Warfarin Sodium [vandf]

57. Chembl1200879

58. Dtxsid7035010

59. Warfarin Sodium [mart.]

60. Hy-b0687a

61. Warfarin Sodium [who-dd]

62. Warfarin Sodium [who-ip]

63. Warfarin Sodium Salt [mi]

64. Coumarin, 3-(alpha-acetonylbenzyl)-4-hydroxy-, Sodium Salt

65. Hms2233p10

66. Hms3259g13

67. Hms3369m10

68. Bcp20702

69. Tox21_301545

70. Bdbm50248297

71. Warfarin Sodium [orange Book]

72. Akos015951251

73. Akos015955387

74. Warfarin Sodium [ep Monograph]

75. Ac-8078

76. Cs-w019743

77. Nc00490

78. Warfarin Sodium [usp Monograph]

79. Ncgc00255556-01

80. Ac-19972

81. Cas-129-06-6

82. Smr000058849

83. Warfarinum Natricum [who-ip Latin]

84. W0005

85. Warfarin Sodium (contains Isopropyl Alcohol)

86. D00564

87. O12075

88. A805899

89. J-005647

90. Sodium Warfarin;warf42 Sodium; Athrombine-k Sodium

91. Q27263296

92. 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin Sodiuim Salt

93. 4-hydroxy-3-(3-oxo-1-phenylbutyl)coumarin Sodium Salt

94. Sodium 2-oxo-3-(3-oxo-1-phenylbutyl)-1-benzopyran-4-olate

95. 3-(.alpha.-acetonylbenzyl)-4-hydroxycoumarin Sodium Salt

96. Sodium 2-oxidanylidene-3-(3-oxidanylidene-1-phenyl-butyl)chromen-4-olate

97. 2h-1-benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, Sodium Salt (1:1)

2.4 Create Date

2007-07-11

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₅NaO₄
Molecular Weight	330.3 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	330.08680324 g/mol
Monoisotopic Mass	330.08680324 g/mol
Topological Polar Surface Area	66.4 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	508
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Jantoven
PubMed Health	Warfarin
Drug Classes	Anticoagulant
Drug Label	JantovenTablets (crystalline warfarin sodium) is an anticoagulant which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an isopropan...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Usl Pharma

2 of 4
Drug Name	Warfarin sodium
Drug Label	Warfarin sodium tablet (crystalline warfarin sodium) is an anticoagulant, which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an i...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Amneal Pharms; Taro; Invagen Pharms; Ipca Labs; Zydus Pharms Usa; Pliva; Mylan; Barr

3 of 4
Drug Name	Jantoven
PubMed Health	Warfarin
Drug Classes	Anticoagulant
Drug Label	JantovenTablets (crystalline warfarin sodium) is an anticoagulant which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an isopropan...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Usl Pharma

4 of 4
Drug Name	Warfarin sodium
Drug Label	Warfarin sodium tablet (crystalline warfarin sodium) is an anticoagulant, which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an i...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Amneal Pharms; Taro; Invagen Pharms; Ipca Labs; Zydus Pharms Usa; Pliva; Mylan; Barr

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anticoagulants

Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)

Rodenticides

Substances used to destroy or inhibit the action of rats, mice, or other rodents. (See all compounds classified as Rodenticides.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Vitamin K Inhibitors [MoA]; Vitamin K Antagonist [EPC]

Find Warfarin Sodium manufacturers, exporters & distributors on PharmaCompass

MolPort-002-130-141

MolPort-002-130-141

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

31 API Suppliers

19 USDMF

14 CEP/COS

6 EU WC

5 NDC API

16 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Exports

FDF Imports

INTERMEDIATES

5 Suppliers

DOSSIERs // Finished Dosage Formulations

172 Dossiers

118 FDA Orange Book

5 Europe

19 Canada

6 Australia

6 South Africa

18 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 10MG

TABLET;ORAL - 1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - 2.5MG

TABLET;ORAL - 2MG

TABLET;ORAL - 3MG

TABLET;ORAL - 4MG

TABLET;ORAL - 5MG

TABLET;ORAL - 6MG

TABLET;ORAL - 7.5MG

RELATED EXCIPIENT COMPANIES

Suppliers

37 Kerry

21 SPI Pharma

16 Roquette

14 Microlex e.U

10 Gangwal Healthcare

10 BASF

10 Sigachi Industries

10 Corel Pharma Chem

8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

7 Seppic

7 Gangwal Chemicals

6 Lonza Capsugel

6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

6 DFE Pharma

5 Ideal Cures Pvt Ltd

4 Ingredion Pharma Solutions

3 Kima Chemical

3 Prachin Chemical

3 Vasa Pharmachem

2 The Dow Chemical Company

2 Rochem International Inc

2 Actylis

2 Pharmatrans-Sanaq

1 Ulanqab Kema New Material

1 ACG Worldwide

1 Qualicaps

1 Qianhao Chemical (Hebei) Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

1 Boai NKY Pharmaceuticals Ltd

1 DKSH

1 Pfanstiehl

1 Jai Radhe Sales

1 Nanjing Well Pharmaceutical

EXCIPIENTS BY APPLICATIONS

77 Fillers, Diluents & Binders

40 Coating Systems & Additives

37 Direct Compression

23 Controlled & Modified Release

TABLET;ORAL - 1MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons