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Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

24 API Suppliers, 15 USDMF, 8 CEP/COS, 2 JDMF, 5 EU WC, 3 KDMF, 8 NDC API, 14 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

INTERMEDIATES

3 Suppliers

3 Suppliers

DOSSIERs // Finished Dosage Formulations

176 Dossiers, 55 FDA Orange Book, 39 Europe, 12 Canada, 36 Australia, 9 South Africa, 25 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 100MG, TABLET;ORAL - 200MG, TABLET;ORAL - 25MG, TABLET;ORAL - 50MG, SUSPENSION;ORAL - 50MG/ML, TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - 100MG
TABLET;ORAL - 200MG
TABLET;ORAL - 25MG
TABLET;ORAL - 50MG
SUSPENSION;ORAL - 50MG/ML
TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers, 28 Kerry, 28 Roquette, 19 SPI Pharma, 15 BASF, 13 Microlex e.U, 12 Gangwal Healthcare, 11 Sigachi Industries, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 DFE Pharma, 6 Gangwal Chemicals, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 5 Rochem International Inc, 5 Boai NKY Pharmaceuticals Ltd, 4 Ingredion Pharma Solutions, 4 Prachin Chemical, 4 Pharmatrans-Sanaq, 3 DKSH, 3 Ulanqab Kema New Material, 3 Vasa Pharmachem, 3 Actylis, 2 Shijiazhuang Huaxu Pharmaceutical, 2 Corel Pharma Chem, 2 Ideal Cures Pvt Ltd, 2 Nanjing Well Pharmaceutical, 2 Zhejiang Huakang Pharmaceutical, 1 Chynops Pharma, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Alcedo Pharmachem, 1 Minakem, 1 Jai Radhe Sales, 1 Evonik, 1 Pfanstiehl, 1 Aeon Procare, 1 Seppic, 1 NEWEDGE Overseas, 1 Pharm-RX Chemical

EXCIPIENTS BY APPLICATIONS

84 Fillers, Diluents & Binders, 37 Direct Compression, 24 Disintegrants & Superdisintegrants, 23 Taste Masking, 22 Lubricants & Glidants, 21 Granulation, 20 Chewable & Orodispersible Aids, 18 Thickeners and Stabilizers, 17 Coating Systems & Additives, 17 Co-Processed Excipients, 15 Film Formers & Plasticizers, 14 Controlled & Modified Release, 10 Parenteral, 8 Solubilizers, 5 API Stability Enhancers, 2 Topical, 2 Emulsifying Agents, 1 Soft Gelatin, 1 Rheology Modifiers

GLOBAL SALES INFORMATION

37 US Medicaid Prescriptions, 36 Finished Drug Prices

MARKET PLACE

5 APIs, 7 DOSSIERS // FDF, 1 Intermediates

PATENTS

1 US Patents

1 US Patents

ANALYTICAL SOLUTION(s)

1 BioAnalytical Methods, 2 EDQM Standards, 2 USP Standards, 6 Other Ref. Standards

DIGITAL CONTENT

1 Data Compilations & Company Tracker #PharmaFlow, 28 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

198

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

1,049.00

Annual Reports

FDF Market Place

EXCIPIENTS

205

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as:

Molecular Formula

C₁₈H₁₉ClN₄

Molecular Weight

326.8 g/mol

InChI Key

ZUXABONWMNSFBN-UHFFFAOYSA-N

1 2D Structure

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2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

2.1.2 InChI

InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3

2.1.3 InChI Key

ZUXABONWMNSFBN-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

2.1.5 Isomeric SMILES

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

2.2 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₉ClN₄
Molecular Weight	326.8 g/mol
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	326.1298243 g/mol
Monoisotopic Mass	326.1298243 g/mol
Topological Polar Surface Area	30.9 A^2
Heavy Atom Count	23
Formal Charge	0
Complexity	584
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Clozapine
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	VERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	200mg; 100mg; 25mg; 50mg; 12.5mg
Market Status	Prescription
Company	Ivax Sub Teva Pharms; Sun Pharm Inds; Mylan

2 of 6
Drug Name	Clozaril
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	CLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	100mg; 25mg
Market Status	Prescription
Company	Novartis

3 of 6
Drug Name	Fazaclo odt
Active Ingredient	Clozapine
Dosage Form	Tablet, orally disintegrating
Route	Oral
Strength	200mg; 100mg; 25mg; 150mg; 12.5mg
Market Status	Prescription
Company	Jazz Pharms Iii

4 of 6
Drug Name	Clozapine
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	VERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	200mg; 100mg; 25mg; 50mg; 12.5mg
Market Status	Prescription
Company	Ivax Sub Teva Pharms; Sun Pharm Inds; Mylan

5 of 6
Drug Name	Clozaril
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	CLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	100mg; 25mg
Market Status	Prescription
Company	Novartis

6 of 6
Drug Name	Fazaclo odt
Active Ingredient	Clozapine
Dosage Form	Tablet, orally disintegrating
Route	Oral
Strength	200mg; 100mg; 25mg; 150mg; 12.5mg
Market Status	Prescription
Company	Jazz Pharms Iii

Find Clozapine manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

24 API Suppliers

15 USDMF

8 CEP/COS

2 JDMF

5 EU WC

3 KDMF

8 NDC API

14 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Imports

INTERMEDIATES

3 Suppliers

DOSSIERs // Finished Dosage Formulations

176 Dossiers

55 FDA Orange Book

39 Europe

12 Canada

36 Australia

9 South Africa

25 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 100MG

TABLET;ORAL - 200MG

TABLET;ORAL - 25MG

TABLET;ORAL - 50MG

SUSPENSION;ORAL - 50MG/ML

TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, ORALLY DISINTEGRATING;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, ORALLY DISINTEGRATING;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, ORALLY DISINTEGRATING;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers

28 Kerry

28 Roquette

19 SPI Pharma

15 BASF

13 Microlex e.U

12 Gangwal Healthcare

11 Sigachi Industries

7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

6 DFE Pharma

6 Gangwal Chemicals

5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

5 Rochem International Inc

5 Boai NKY Pharmaceuticals Ltd

4 Ingredion Pharma Solutions

4 Prachin Chemical

4 Pharmatrans-Sanaq

3 DKSH

3 Ulanqab Kema New Material

3 Vasa Pharmachem

3 Actylis

2 Shijiazhuang Huaxu Pharmaceutical

2 Corel Pharma Chem

2 Ideal Cures Pvt Ltd

2 Nanjing Well Pharmaceutical

2 Zhejiang Huakang Pharmaceutical

1 Chynops Pharma

1 Shanghai Welltone Material Technology Co., Ltd

1 Alcedo Pharmachem

1 Minakem

1 Jai Radhe Sales

1 Evonik

1 Pfanstiehl

1 Aeon Procare

1 Seppic

1 NEWEDGE Overseas

1 Pharm-RX Chemical

TABLET, ORALLY DISINTEGRATING;ORAL - 100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, ORALLY DISINTEGRATING;ORAL - 150MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, ORALLY DISINTEGRATING;ORAL - 200MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, ORALLY DISINTEGRATING;ORAL - 25MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons