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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

25 API Suppliers, 15 USDMF, 9 CEP/COS, 1 JDMF, 5 EU WC, 3 KDMF, 8 NDC API, 13 Listed Suppliers, $ API Reference Price

25 API Suppliers
15 USDMF
9 CEP/COS
1 JDMF
5 EU WC
3 KDMF
8 NDC API
13 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

3 Intermediates Suppliers

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

198 FDF Dossiers, 55 FDA Orange Book, 60 Europe, 12 Canada, 36 Australia, 9 South Africa, 26 Listed Dossiers

198 FDF Dossiers
55 FDA Orange Book
60 Europe
12 Canada
36 Australia
9 South Africa
26 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 100MG, TABLET;ORAL - 200MG, TABLET;ORAL - 25MG, TABLET;ORAL - 50MG, SUSPENSION;ORAL - 50MG/ML, TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

drugProductComposition
TABLET;ORAL - 100MG
TABLET;ORAL - 200MG
TABLET;ORAL - 25MG
TABLET;ORAL - 50MG
SUSPENSION;ORAL - 50MG/ML
TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

1 Minakem, 1 Evonik, 5 Rochem International Inc, 19 SPI Pharma, 3 DKSH, 1 Jai Radhe Sales, 1 Pharm-RX Chemical, 6 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 14 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 3 Actylis, 1 Aeon Procare, 1 Alcedo Pharmachem, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 15 BASF, 2 Corel Pharma Chem, 6 DFE Pharma, 6 Gangwal Chemicals, 2 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 28 Kerry, 13 Microlex e.U, 1 NEWEDGE Overseas, 1 Novo Excipients, 4 Pharmatrans-Sanaq, 7 Pluviaendo, 4 Prachin Chemical, 28 Roquette, 1 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 2 Shijiazhuang Huaxu Pharmaceutical, 11 Sigachi Industries, 3 Ulanqab Kema New Material, 1 Valens Pharmachem, 3 Vasa Pharmachem, 2 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

88 Fillers, Diluents & Binders, 41 Direct Compression, 24 Disintegrants & Superdisintegrants, 24 Taste Masking, 23 Lubricants & Glidants, 22 Granulation, 21 Thickeners and Stabilizers, 21 Co-Processed Excipients, 20 Chewable & Orodispersible Aids, 17 Coating Systems & Additives, 16 Film Formers & Plasticizers, 14 Controlled & Modified Release, 12 Parenteral, 8 Solubilizers, 5 API Stability Enhancers, 5 Topical, 3 Rheology Modifiers, 3 Emulsifying Agents, 1 Soft Gelatin, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 29 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
29 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 US Medicaid Prescriptions, 57 Finished Drug Prices

globalSalesInformation
3 US Medicaid Prescriptions
57 Finished Drug Prices

MARKET PLACE

5 APIs, 7 FDF Dossiers, 1 Intermediates

marketPlace
5 APIs
7 FDF Dossiers
1 Intermediates

PATENTS & EXCLUSIVITIES

1 US Patents

patents
1 US Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 7 Others

otherSolutions
2 EDQM
2 USP
7 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 198

MARKET PLACE

API

FDF

3INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

198

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

108,566,088

Annual Reports (USD Million)

Finished Drug Prices

217 RELATED EXCIPIENT COMPANIES

369EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as:

Molecular Formula

C₁₈H₁₉ClN₄

Molecular Weight

326.8 g/mol

InChI Key

ZUXABONWMNSFBN-UHFFFAOYSA-N

1 2D Structure

Clozapine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

2.1.2 InChI

InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3

2.1.3 InChI Key

ZUXABONWMNSFBN-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

2.1.5 Isomeric SMILES

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

2.2 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₉ClN₄
Molecular Weight	326.8 g/mol
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	326.1298243 g/mol
Monoisotopic Mass	326.1298243 g/mol
Topological Polar Surface Area	30.9 A^2
Heavy Atom Count	23
Formal Charge	0
Complexity	584
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Clozapine
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	VERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	200mg; 100mg; 25mg; 50mg; 12.5mg
Market Status	Prescription
Company	Ivax Sub Teva Pharms; Sun Pharm Inds; Mylan

2 of 6
Drug Name	Clozaril
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	CLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	100mg; 25mg
Market Status	Prescription
Company	Novartis

3 of 6
Drug Name	Fazaclo odt
Active Ingredient	Clozapine
Dosage Form	Tablet, orally disintegrating
Route	Oral
Strength	200mg; 100mg; 25mg; 150mg; 12.5mg
Market Status	Prescription
Company	Jazz Pharms Iii

4 of 6
Drug Name	Clozapine
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	VERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	200mg; 100mg; 25mg; 50mg; 12.5mg
Market Status	Prescription
Company	Ivax Sub Teva Pharms; Sun Pharm Inds; Mylan

5 of 6
Drug Name	Clozaril
PubMed Health	Clozapine (By mouth)
Drug Classes	Antipsychotic
Drug Label	CLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
Active Ingredient	Clozapine
Dosage Form	Tablet
Route	Oral
Strength	100mg; 25mg
Market Status	Prescription
Company	Novartis

6 of 6
Drug Name	Fazaclo odt
Active Ingredient	Clozapine
Dosage Form	Tablet, orally disintegrating
Route	Oral
Strength	200mg; 100mg; 25mg; 150mg; 12.5mg
Market Status	Prescription
Company	Jazz Pharms Iii

API SUPPLIERS

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USDMF

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CEP/COS

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"CLOZAPINE","year":"2021","qtr":"Q1","strtotime":1611167400,"product":"PHARMACEUTICAL BULK DRUG CLOZAPINE USP B ATCH NO. CL0Z\/89","address":"RAY HOUSE, HIG NO. 2000, YELAHANKA NEW TOWN, YELAHANKA, MOTHER DIARY","city":"ROAD, YELAHANKA NEW TOWN, BANGALORE","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"INCEPTA PHARMACEUTICALS LTD","customerCountry":"BANGLADESH","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"233.6","totalValueFC":"4730.7","currency":"USD","unitRateINR":17299.279999999999,"date":"21-Jan-2021","totalValueINR":"345985.6","totalValueInUsd":"4730.7","indian_port":"BANGALORE AIR","hs_no":"29420090","bill_no":"8049788","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"RAY HOUSE, HIG NO. 2000, YELAHANKA NEW TOWN, YELAHANKA, MOTHER DIARY, ROAD, YELAHANKA NEW TOWN, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"CLOZAPINE","year":"2021","qtr":"Q1","strtotime":1612290600,"product":"CLOZAPINE","address":"H NO 7 58 214 SIDDARTHA NAGAR,DAMM AIGUDA HYDERABAD RANGAREDDI","city":"HYDERABAD,TELANGANA","supplier":"AURORE LIFE SCIENCES","supplierCountry":"INDIA","foreign_port":"SHEREMETYEVO","customer":"TO THE ORDER OF","customerCountry":"RUSSIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"200.6","totalValueFC":"198.5","currency":"USD","unitRateINR":14453.57,"date":"03-Feb-2021","totalValueINR":"14453.57","totalValueInUsd":"198.5","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"8371740","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"H NO 7 58 214 SIDDARTHA NAGAR,DAMM AIGUDA HYDERABAD RANGAREDDI, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"CLOZAPINE","year":"2021","qtr":"Q1","strtotime":1614537000,"product":"CLOZAPINE","address":"1-1-151\/1, SAIRAM TOWERS, 4TH FLOORALEXANDER ROAD","city":"SECUNDERABAD, ANDHRA PRADESH","supplier":"VIATRIS","supplierCountry":"INDIA","foreign_port":"DUBLIN","customer":"VIATRIS","customerCountry":"IRELAND","quantity":"266.11","actualQuantity":"266.11","unit":"KGS","unitRateFc":"140.9","totalValueFC":"37116","currency":"USD","unitRateINR":10154.065010709857,"date":"01-Mar-2021","totalValueINR":"2702098.24","totalValueInUsd":"37116","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"9027957","productDescription":"API","marketType":"REGULATED MARKET","country":"IRELAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"1-1-151\/1, SAIRAM TOWERS, 4TH FLOORALEXANDER ROAD, SECUNDERABAD, ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"CLOZAPINE","year":"2021","qtr":"Q2","strtotime":1617215400,"product":"CLOZAPINE GRADE USP BATCH NO.LF-CLOZ\/022","address":"PLOT NO.36, `AASHISH`,SHIVANI NAGAR SOC. 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SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724437800,"product":"CLOZAPINE IP","address":"ACME PLAZA , ANDHERI KURLA ROAD","city":"MUMBAI","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"80","totalValueFC":"40870.5","currency":"USD","unitRateINR":"6788","date":"24-Aug-2024","totalValueINR":"3394000","totalValueInUsd":"40870.5","indian_port":"JNPT","hs_no":"29335990","bill_no":"5232321","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"OFFICE F, 32\/F, PLAZA 88 NO. 88 YEUNG UK ROAD, TSUEN WAN, NT Hong Kong, , Hong Kong Hong Kong","customerAddress":"ACME PLAZA , ANDHERI KURLA ROAD"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET;ORAL - 100MG

USFDA APPLICATION NUMBER - 19758

DOSAGE - TABLET;ORAL - 200MG

USFDA APPLICATION NUMBER - 19758

DOSAGE - TABLET;ORAL - 25MG

USFDA APPLICATION NUMBER - 19758

DOSAGE - TABLET;ORAL - 50MG

USFDA APPLICATION NUMBER - 19758

DOSAGE - SUSPENSION;ORAL - 50MG/ML

USFDA APPLICATION NUMBER - 203479

DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**