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Mizolastine

Mizolastine

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Also known as: 108612-45-9, Mizollen, Zolistan, Sl 85.0324, Mistamine, 2-((1-(1-(p-fluorobenzyl)-2-benzimidazolyl)-4-piperidyl)methylamino)-4(3h)-pyrimidinone

Molecular Formula

C₂₄H₂₅FN₆O

Molecular Weight

432.5 g/mol

InChI Key

PVLJETXTTWAYEW-UHFFFAOYSA-N

FDA UNII

244O1F90NA

Mizolastine is under investigation in clinical trial NCT01928316 (A Bioequivalence Study of Domestic (Made in China) and Imported Mizolastine Tablets in Healthy Volunteers).

1 2D Structure

Mizolastine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-1H-pyrimidin-6-one

2.1.2 InChI

InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)

2.1.3 InChI Key

PVLJETXTTWAYEW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(=O)N5

2.2 Other Identifiers

2.2.1 UNII

244O1F90NA

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Mistalin

2. Mistamine

3. Mizolen

4. Mizollen

5. Sl 85.0324

6. Sl-85.0324

7. Zolim

8. Zolistan

2.3.2 Depositor-Supplied Synonyms

1. 108612-45-9

2. Mizollen

3. Zolistan

4. Sl 85.0324

5. Mistamine

6. 2-((1-(1-(p-fluorobenzyl)-2-benzimidazolyl)-4-piperidyl)methylamino)-4(3h)-pyrimidinone

7. Mizolastine (mizollen)

8. Mkc-431

9. Chembl94454

10. 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-1h-pyrimidin-6-one

11. Mistalin

12. 244o1f90na

13. Mizolastine [inn]

14. Ncgc00181013-01

15. Mizolastina

16. Mizolastinum

17. Mizolen

18. Zolim

19. Dsstox_cid_26801

20. Dsstox_rid_81916

21. Dsstox_gsid_46801

22. 2-((1-(1-(4-fluorobenzyl)-1h-benzo[d]imidazol-2-yl)piperidin-4-yl)(methyl)amino)pyrimidin-4(3h)-one

23. 2-[[1-[1-[(4-fluorophenyl)methyl]benzoimidazol-2-yl]-4-piperidyl]-methyl-amino]-3h-pyrimidin-4-one

24. Mizolastinum [inn-latin]

25. Mizolastina [inn-spanish]

26. Zolistam

27. 2-{1-[1-(4-fluorobenzyl)-1h-benzimidazol-2-yl]-4-piperidyl(methyl)amino}pyrimidin-4(1h)-one

28. Sl-85.0324

29. Mizollen (tn)

30. 2-((1-(1-(4-fluorobenzyl)-1h-benzo[d]imidazol-2-yl)-piperidin-4-yl)(methyl)amino)pyrimidin-4(1h)-one

31. Cas-108612-45-9

32. Mizolastine (jan/inn)

33. Mizolastine [inn:ban]

34. Unii-244o1f90na

35. Ccris 8410

36. Sl 850324

37. Mizolastine [mi]

38. Mizolastine [jan]

39. Schembl5061

40. Mizolastine [mart.]

41. Mizolastine [who-dd]

42. Mls006010068

43. Mkc431

44. Dtxsid5046801

45. Bdbm22877

46. Chebi:31857

47. Gtpl10102

48. Hms3713n04

49. Hy-b0164

50. Tox21_112663

51. Ac-634

52. Mfcd23140913

53. Zinc13831810

54. Akos005145756

55. Akos016003409

56. Tox21_112663_1

57. Ccg-220621

58. Cs-1997

59. Db12523

60. Ks-1139

61. Ncgc00344565-01

62. Ncgc00344565-04

63. 4(1h)-pyrimidinone, 2-((1-(1-((4-fluorophenyl)methyl)-1h-benzimidazol-2-yl)-4-piperidinyl)methylamino)-

64. Sl850324

65. Smr003965484

66. Sl-850324

67. Ft-0628955

68. M2756

69. D01117

70. T71584

71. Ab01566892_01

72. 612m459

73. A801901

74. Q417830

75. J-507624

76. Brd-k21884483-001-01-1

77. (4-ethoxy-2-oxo-2,5-dihydro-pyrrol-1-yl)-aceticacid

78. 2-({1-[1-(4-fluoro-benzyl)-1h-benzoimidazol-2-yl]-piperidin-4-yl}-methyl-amino)-3h-pyrimidin-4-one

79. 2-({1-[1-(4-fluorobenzyl)-1h-benzimidazol-2-yl]-piperidin-4-yl}-methylamino)-4(1h) Pyrimidinone

80. 2-[[1-[1-[(4-fluorophenyl)methyl]-2-benzimidazolyl]-4-piperidinyl]-methylamino]-1h-pyrimidin-6-one

81. 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]- Methylamino]-1h-pyrimidin-6-one

82. 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methyl-amino]-1h-pyrimidin-6-one

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₅FN₆O
Molecular Weight	432.5 g/mol
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	432.20738760 g/mol
Monoisotopic Mass	432.20738760 g/mol
Topological Polar Surface Area	65.8 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	728
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists, Non-Sedating

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. (See all compounds classified as Histamine H1 Antagonists, Non-Sedating.)

4.2 ATC Code

R06AX25

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

R - Respiratory system

R06 - Antihistamines for systemic use

R06A - Antihistamines for systemic use

R06AX - Other antihistamines for systemic use

R06AX25 - Mizolastine