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Mianserin
Also known as: 21535-47-7, Mianserin hcl, Mianserine hydrochloride, Athymil, Bolvidon, Tolvon
Molecular Formula
C18H21ClN2
Molecular Weight
300.8  g/mol
InChI Key
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
FDA UNII
2X03TN217S

A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
1 2D Structure

Mianserin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene;hydrochloride
2.1.2 InChI
InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
2.1.3 InChI Key
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl
2.2 Other Identifiers
2.2.1 UNII
2X03TN217S
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hydrochloride, Mianserin

2. Lerivon

3. Mianserin

4. Mianserin Monohydrochloride

5. Monohydrochloride, Mianserin

6. Org Gb 94

7. Tolvon

2.3.2 Depositor-Supplied Synonyms

1. 21535-47-7

2. Mianserin Hcl

3. Mianserine Hydrochloride

4. Athymil

5. Bolvidon

6. Tolvon

7. Org Gb 94

8. Mianserin (hydrochloride)

9. Lerivon

10. Tetramide

11. Mianserine Hcl

12. 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride

13. Mls000069681

14. 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride

15. Org Gb-94 Hcl

16. Nsc-759590

17. Smr000058472

18. Org-gb 94

19. 2x03tn217s

20. 1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,f)-pyrazino(1,2-a)azepine Monohydrochloride

21. Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, Monohydrochloride

22. Tolvin

23. 1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine Hydrochloride

24. Chebi:31843

25. Sr-01000000185

26. C18h20n2.hcl

27. Gb 94

28. Tetramide (tn)

29. Prestwick_514

30. Einecs 244-426-7

31. Mianserin Hydrochloride [usan:jan]

32. Mfcd00055072

33. (.+-.)-athymil

34. Opera_id_1505

35. (.+-.)-norval

36. Cid_68551

37. Mls001148213

38. Mls002222220

39. Schembl340474

40. Spectrum2300292

41. Unii-2x03tn217s

42. Chembl544428

43. Mianserin Hydrochloride Solution

44. Mianserin For System Suitability

45. Bdbm31005

46. Hy-b0188a

47. Dtxsid30944145

48. Hms1568c20

49. Pharmakon1600-02300292

50. Bcp09259

51. Mianserin Hydrochloride (jan/usan)

52. Mianserin Hydrochloride [mi]

53. Tox21_500744

54. Ccg-39108

55. Mianserin Hydrochloride [jan]

56. Nsc292267

57. Nsc759590

58. S1382

59. Mianserin Hydrochloride [usan]

60. Akos015902308

61. Cs-2079

62. Ks-5096

63. Lp00744

64. Mianserin Hydrochloride [mart.]

65. Nsc 759590

66. Nsc-292267

67. Mianserin Hydrochloride [who-dd]

68. Ncgc00094086-01

69. Ncgc00094086-02

70. Ncgc00094086-03

71. Ncgc00094086-04

72. Ncgc00261429-01

73. Ac-25005

74. Bm166416

75. Db-045611

76. Eu-0100744

77. M2623

78. Sw196707-3

79. Mianserin Hydrochloride [ep Monograph]

80. C74052

81. D01358

82. M 2525

83. 535m477

84. A912434

85. Sr-01000000185-2

86. Sr-01000000185-4

87. Sr-01000000185-8

88. W-111733

89. Q27114695

90. Mianserin Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

91. Mianserin Hydrochloride, Analytical Standard, For Drug Analysis

92. Mianserin Hydrochloride, European Pharmacopoeia (ep) Reference Standard

93. 1,2,3,4,10,14b-hexahydro-2-methyldi Benzo[c,f]pyrazino[1,2-a]azepine Hydrochloride

94. 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyryzino[1,2-a]azepine Hydrochloride

95. 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepinehydrochloride

96. Mianserin For System Suitability, European Pharmacopoeia (ep) Reference Standard

97. 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7.0^{8,13]nonadeca-1(19),8,10,12,15,17-hexaene;hydrochloride

98. 5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene;hydrochloride

99. 78644-54-9

100. Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, Hydrochloride (1:1)

101. Hydron;5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene;chloride

102. Mianserin Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 300.8 g/mol
Molecular Formula C18H21ClN2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass300.1393264 g/mol
Monoisotopic Mass300.1393264 g/mol
Topological Polar Surface Area6.5 Ų
Heavy Atom Count21
Formal Charge0
Complexity342
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adrenergic alpha-Antagonists

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)


Antidepressive Agents, Second-Generation

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)


Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)


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